Self-association of the transmembrane domain of RET underlies oncogenic activation by MEN2A mutations (Q40274230)

19 September 2017

Self-association of the transmembrane domain of RET underlies oncogenic activation by MEN2A mutations (English)

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19 September 2017

transmembrane protein

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author

Susanne Krüger Kjaer

1

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19 September 2017

Kurokawa K

2

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19 September 2017

Perrinjaquet M

3

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19 September 2017

Abrescia C

4

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19 September 2017

Ibáñez CF

5

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19 September 2017

language of work or name

English

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publication date

29 May 2006

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19 September 2017

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19 September 2017

25

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53

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19 September 2017

7086-7095

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1209698

19 September 2017

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Dual effect on the RET receptor of MEN 2 mutations affecting specific extracytoplasmic cysteines

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Mutations of the RET proto-oncogene in Hirschsprung's disease

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Quality control in the endoplasmic reticulum

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Two distinct mutations of the RET receptor causing Hirschsprung's disease impair the binding of signalling effectors to a multifunctional docking site

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Polar side chains drive the association of model transmembrane peptides

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Functional analysis of RET with Hirschsprung mutations affecting its kinase domain

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Receptor signaling: when dimerization is not enough

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Phenotype-genotype correlation in Hirschsprung disease is illuminated by comparative analysis of the RET protein sequence

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Intrinsic susceptibility to misfolding of a hot-spot for Hirschsprung disease mutations in the ectodomain of RET.

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Self assembly of the transmembrane domain promotes signal transduction through the erythropoietin receptor

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Dimerization of the transmembrane domain of Integrin alphaIIb subunit in cell membranes

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Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation

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Essential role of a GXXXG motif for membrane channel formation by Helicobacter pylori vacuolating toxin

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The single transmembrane domains of ErbB receptors self-associate in cell membranes

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Two germline missense mutations at codons 804 and 806 of the RET proto-oncogene in the same allele in a patient with multiple endocrine neoplasia type 2B without codon 918 mutation.

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Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B

21 January 2018

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Cell signaling by receptor tyrosine kinases

21 January 2018

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Motifs of two small residues can assist but are not sufficient to mediate transmembrane helix interactions

21 January 2018

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Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs

21 January 2018

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Statistical analysis of amino acid patterns in transmembrane helices: the GxxxG motif occurs frequently and in association with beta-branched residues at neighboring positions.

21 January 2018

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The transmembrane domains of ErbB receptors do not dimerize strongly in micelles

21 January 2018

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ret transforming gene encodes a fusion protein homologous to tyrosine kinases

21 January 2018

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21 January 2018

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ZD6474 suppresses oncogenic RET isoforms in a Drosophila model for type 2 multiple endocrine neoplasia syndromes and papillary thyroid carcinoma.

21 January 2018

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Distinct regions of human glycophorin A enhance human red cell anion exchanger (band 3; AE1) transport function and surface trafficking.

21 January 2018

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Polar residues drive association of polyleucine transmembrane helices

21 January 2018

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Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC

21 January 2018

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21 January 2018

One gene—four syndromes

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Biological effects of the dual phenotypic Janus mutation of ret cosegregating with both multiple endocrine neoplasia type 2 and Hirschsprung's disease

21 January 2018

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7 January 2021

Germline dinucleotide mutation in codon 883 of the RET proto-oncogene in multiple endocrine neoplasia type 2B without codon 918 mutation

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7 January 2021

A heptad motif of leucine residues found in membrane proteins can drive self-assembly of artificial transmembrane segments

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7 January 2021

Duplication of 9 base pairs in the critical cysteine-rich domain of the RET proto-oncogene causes multiple endocrine neoplasia type 2A

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7 January 2021

A duplication of 12 bp in the critical cysteine rich domain of the RET proto-oncogene results in a distinct phenotype of multiple endocrine neoplasia type 2A

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209698

7 January 2021

Protein mobility and GABA-induced conformational changes in GABA(A) receptor pore-lining M2 segment

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7 January 2021

Biological and biochemical properties of Ret with kinase domain mutations identified in multiple endocrine neoplasia type 2B and familial medullary thyroid carcinoma

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209698

7 January 2021

RET mutation screening in MEN2 patients and discovery of a novel mutation in a sporadic medullary thyroid carcinoma

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209698

7 January 2021

Three novel mutations in the RET proto-oncogene

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209698

7 January 2021

Structural requirements of the extracellular to transmembrane domain junction for erythropoietin receptor function.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209698

7 January 2021

Sequence-specific Dimerization of the Transmembrane Domain of the “BH3-only” Protein BNIP3 in Membranes and Detergent

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209698

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209698

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Dimensions Publication ID

19 September 2017

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