The SREBP pathway--insights from Insigs and insects (Q34223258)

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title

The SREBP pathway--insights from Insigs and insects (English)

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sterol regulatory element binding protein cleavage

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Gene Ontology ID

GO:0035103

SREBP signaling pathway

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Gene Ontology ID

GO:0032936

SREBP-SCAP-Insig complex

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SREBP cleavage activating protein Dmel_CG33131

Gene Ontology ID

GO:0032937

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Site-2 protease Dmel_CG8988

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Sterol regulatory element binding protein Dmel_CG8522

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S1P Dmel_CG7169

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author name string

Robert B Rawson

series ordinal

1

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31 July 2017

1 August 2003

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Nature Reviews Molecular Cell Biology

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4

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631-640

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8

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https://scigraph.springernature.com/pub.10.1038/nrm1174

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cites work

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Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes

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Sterols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ER

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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

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Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis

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The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

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SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene

31 March 2020

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SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element

31 March 2020

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SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

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Three different rearrangements in a single intron truncate sterol regulatory element binding protein-2 and produce sterol-resistant phenotype in three cell lines. Role of introns in protein evolution

31 March 2020

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Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells

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Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines.

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Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols.

31 March 2020

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Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein

31 March 2020

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Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies

31 March 2020

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Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein.

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

31 March 2020

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ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Somatic cell genetic and biochemical characterization of cell lines resulting from human genomic DNA transfections of Chinese hamster ovary cell mutants defective in sterol-dependent activation of sterol synthesis and LDL receptor expression

31 March 2020

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31 March 2020

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A novel clan of zinc metallopeptidases with possible intramembrane cleavage properties

31 March 2020

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Overexpression of membrane domain of SCAP prevents sterols from inhibiting SCAP.SREBP exit from endoplasmic reticulum

31 March 2020

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Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

31 March 2020

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Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

31 March 2020

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The hypocholesterolemic agent LY295427 up-regulates INSIG-1, identifying the INSIG-1 protein as a mediator of cholesterol homeostasis through SREBP

31 March 2020

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Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis

31 March 2020

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Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N.

31 March 2020

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Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism

31 March 2020

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Regulation of the mevalonate pathway

31 March 2020

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Partial deletion of membrane-bound domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase eliminates sterol-enhanced degradation and prevents formation of crystalloid endoplasmic reticulum

31 March 2020

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The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl-coenzyme A reductase

31 March 2020

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Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase

31 March 2020

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Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme

31 March 2020

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Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain

31 March 2020

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The SREBP pathway in Drosophila: regulation by palmitate, not sterols

31 March 2020

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The Genome Sequence of the Malaria Mosquito Anopheles gambiae

31 March 2020

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Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver

31 March 2020

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Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis

31 March 2020

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Regulation of phosphatidylcholine metabolism in Chinese hamster ovary cells by the sterol regulatory element-binding protein (SREBP)/SREBP cleavage-activating protein pathway

31 March 2020

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HLH106, a Drosophila transcription factor with similarity to the vertebrate sterol responsive element binding protein.

31 March 2020

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Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells

31 March 2020

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Unsaturated fatty acid-mediated decreases in sterol regulatory element-mediated gene transcription are linked to cellular sphingolipid metabolism

31 March 2020

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Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila

31 March 2020

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C elegans: a model for exploring the genetics of fat storage

31 March 2020

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Inhibition of polyisoprenoid and glycoprotein biosynthesis causes abnormal embryonic development

31 March 2020

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Hairpin orientation of sterol regulatory element-binding protein-2 in cell membranes as determined by protease protection

31 March 2020

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Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi

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Transport-Dependent Proteolysis of SREBP

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Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panning

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Topology of SREBP cleavage-activating protein, a polytopic membrane protein with a sterol-sensing domain.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM1174

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PubMed ID

12923525

Dimensions Publication ID

31 July 2017

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PubMed ID

12923525