Exploring metabolic pathways and regulation through functional chemoproteomic and metabolomic platforms (Q34228026)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25237861%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

review article

1 reference

title

Exploring metabolic pathways and regulation through functional chemoproteomic and metabolomic platforms (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25237861%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

author

Daniel Medina-Cleghorn

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25237861%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

author name string

Daniel K Nomura

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25237861%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

publication date

1 September 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25237861%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

published in

Chemistry and Biology

1 reference

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16 February 2020

volume

21

1 reference

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16 February 2020

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25237861%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

page(s)

1171-1184

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25237861%20AND%20SRC:MED&resulttype=core&format=json

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.

16 February 2020

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink

5 July 2018

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5 July 2018

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ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC

5 July 2018

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HMDB 3.0--The Human Metabolome Database in 2013

5 July 2018

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Monoacylglycerol lipase is a therapeutic target for Alzheimer's disease

5 July 2018

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Activity-based protein profiling reveals mitochondrial oxidative enzyme impairment and restoration in diet-induced obese mice

5 July 2018

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DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses

5 July 2018

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Metabolic footprinting of mutant libraries to map metabolite utilization to genotype

5 July 2018

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Post-translational modification: nature's escape from genetic imprisonment and the basis for dynamic information encoding

5 July 2018

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Functional interplay between caspase cleavage and phosphorylation sculpts the apoptotic proteome

5 July 2018

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A dysregulated endocannabinoid-eicosanoid network supports pathogenesis in a mouse model of Alzheimer's disease

5 July 2018

1 reference

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Activity-based probes for studying the activity of flavin-dependent oxidases and for the protein target profiling of monoamine oxidase inhibitors

5 July 2018

1 reference

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Peptidomics approach to elucidate the proteolytic regulation of bioactive peptides.

5 July 2018

1 reference

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XCMS Online: a web-based platform to process untargeted metabolomic data

5 July 2018

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Innovation: Metabolomics: the apogee of the omics trilogy

5 July 2018

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A two-way street: reciprocal regulation of metabolism and signalling.

5 July 2018

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LC-MS data processing with MAVEN: a metabolomic analysis and visualization engine

5 July 2018

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IDH mutation impairs histone demethylation and results in a block to cell differentiation

5 July 2018

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IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

5 July 2018

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How chemoproteomics can enable drug discovery and development

5 July 2018

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Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity.

5 July 2018

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Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation

5 July 2018

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Potent and selective inhibitors of glutathione S-transferase omega 1 that impair cancer drug resistance

5 July 2018

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Acetyl-CoA drives the transcriptional growth program in yeast

5 July 2018

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Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

5 July 2018

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Monoacylglycerol lipase exerts dual control over endocannabinoid and fatty acid pathways to support prostate cancer

5 July 2018

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Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

5 July 2018

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The metabolic serine hydrolases and their functions in mammalian physiology and disease

5 July 2018

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A photoreactive small-molecule probe for 2-oxoglutarate oxygenases

5 July 2018

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Enhancement of endocannabinoid signaling with JZL184, an inhibitor of the 2-arachidonoylglycerol hydrolyzing enzyme monoacylglycerol lipase, produces anxiolytic effects under conditions of high environmental aversiveness in rats

5 July 2018

1 reference

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Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors

5 July 2018

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A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis

5 July 2018

1 reference

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Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors

5 July 2018

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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

5 July 2018

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Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay

5 July 2018

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Quantitative reactivity profiling predicts functional cysteines in proteomes

5 July 2018

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Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening

5 July 2018

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A fluopol-ABPP HTS assay to identify PAD inhibitors

5 July 2018

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Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

5 July 2018

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Activity-based protein profiling for biochemical pathway discovery in cancer

5 July 2018

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Fatty acid amide hydrolase and monoacylglycerol lipase inhibitors produce anti-allodynic effects in mice through distinct cannabinoid receptor mechanisms.

5 July 2018

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Decoding signalling networks by mass spectrometry-based proteomics

5 July 2018

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Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase

5 July 2018

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Activity-based protein profiling of the hepatitis C virus replication in Huh-7 hepatoma cells using a non-directed active site probe.

5 July 2018

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Expanding the dipeptidyl peptidase 4-regulated peptidome via an optimized peptidomics platform

5 July 2018

1 reference

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5 July 2018

Eicosanoids and cancer

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Imaging approach for monitoring cellular metabolites and ions using genetically encoded biosensors

5 July 2018

1 reference

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RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia

5 July 2018

1 reference

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Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis

5 July 2018

1 reference

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Synthesis of S-adenosyl-L-homocysteine capture compounds for selective photoinduced isolation of methyltransferases

5 July 2018

1 reference

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Exploring disease through metabolomics

5 July 2018

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Activity-based proteome profiling of hepatoma cells during hepatitis C virus replication using protease substrate probes

5 July 2018

1 reference

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

5 July 2018

1 reference

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Peptidomics of prolyl endopeptidase in the central nervous system

5 July 2018

1 reference

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Mining the thiol proteome for sulfenic acid modifications reveals new targets for oxidation in cells

5 July 2018

1 reference

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Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes

5 July 2018

1 reference

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A suite of activity-based probes for human cytochrome P450 enzymes

5 July 2018

1 reference

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Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain

5 July 2018

1 reference

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ATP-citrate lyase links cellular metabolism to histone acetylation

5 July 2018

1 reference

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Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

5 July 2018

1 reference

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Activity-based protein profiling of protein tyrosine phosphatases

5 July 2018

1 reference

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Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171689

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

5 July 2018

1 reference

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Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels

5 July 2018

1 reference

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Global mapping of the topography and magnitude of proteolytic events in apoptosis

5 July 2018

1 reference

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Global sequencing of proteolytic cleavage sites in apoptosis by specific labeling of protein N termini

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171689

A chemical approach for detecting sulfenic acid-modified proteins in living cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171689

Disparate proteome reactivity profiles of carbon electrophiles

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171689

Activation of the endocannabinoid system by organophosphorus nerve agents

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171689

Lipid signalling in disease.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171689

Cyclic changes in metabolic state during the life of a yeast cell

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171689

Chemical proteomic probes for profiling cytochrome p450 activities and drug interactions in vivo

5 July 2018

1 reference

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LIPID MAPS online tools for lipid research

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171689

Functional interrogation of the kinome using nucleotide acyl phosphates

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171689

An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171689

Mechanism-based profiling of enzyme families

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171689

XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171689

Activity-based probes that target diverse cysteine protease families

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171689

METLIN: a metabolite mass spectral database

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171689

Synthesis and testing of mechanism-based protein-profiling probes for retaining endo-glycosidases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171689

Assignment of endogenous substrates to enzymes by global metabolite profiling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171689

Activity-based probes for the proteomic profiling of metalloproteases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171689

The emerging role of lysophosphatidic acid in cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171689

Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171689

Global analysis of proteasomal substrate specificity using positional-scanning libraries of covalent inhibitors.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171689

Profiling the specific reactivity of the proteome with non-directed activity-based probes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171689

The Sequence of the Human Genome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171689

Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171689

Activity-based protein profiling: the serine hydrolases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171689

Chemical dissection of an essential redox switch in yeast

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171689

Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171689

A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171689

A streamlined platform for high-content functional proteomics of primary human specimens

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171689

Discovery metabolite profiling--forging functional connections between the proteome and metabolome

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171689

Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne [3 + 2] cycloaddition

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171689

Profiling serine hydrolase activities in complex proteomes

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171689

Substrate mimicry in an activity-based probe that targets the nitrilase family of enzymes

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25237861

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Quantification of protein sulfenic acid modifications using isotope-coded dimedone and iododimedone

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25237861

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CHEMBIOL.2014.07.007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25237861%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25237861%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

PubMed publication ID

25237861

1 reference