Lipid signalling in disease. (Q37064018)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18216772%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

review article

1 reference

title

Lipid signalling in disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18216772%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18216772%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Roger Schneiter

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18216772%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

author name string

Matthias P Wymann

series ordinal

1

1 reference

18 August 2017

Roger Schneiter

series ordinal

2

1 reference

18 August 2017

1 February 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18216772%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Molecular Cell Biology

1 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18216772%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

volume

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18216772%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18216772%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

page(s)

162-176

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18216772%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrm2335

1 January 2020

exact match

0 references

cites work

The formation of lysocithin and of a muscle-stimulating substance by snake venoms

1 reference

On the specific vaso-dilating and plain muscle stimulating substances from accessory genital glands in man and certain animals (prostaglandin and vesiglandin)

31 March 2020

1 reference

Mast cells and eicosanoid mediators: a system of reciprocal paracrine and autocrine regulation

31 March 2020

1 reference

Targeting the protein kinase C family: are we there yet?

31 March 2020

1 reference

Phosphoinositide 3-kinase signalling--which way to target?

31 March 2020

1 reference

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

31 March 2020

1 reference

Phosphoinositides in cell regulation and membrane dynamics

31 March 2020

1 reference

A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death

31 March 2020

1 reference

The complex life of simple sphingolipids

31 March 2020

1 reference

Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network

31 March 2020

1 reference

Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs

31 March 2020

1 reference

Lysophospholipid receptors: signaling and biology

31 March 2020

1 reference

Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolism

31 March 2020

1 reference

Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia

31 March 2020

1 reference

PPAR gamma and human metabolic disease

31 March 2020

1 reference

Molecular regulation of mast cell activation

31 March 2020

1 reference

Essential role for the p110delta phosphoinositide 3-kinase in the allergic response

31 March 2020

1 reference

Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K.

31 March 2020

1 reference

Src family kinases and lipid mediators in control of allergic inflammation

31 March 2020

1 reference

Calcium mobilization via sphingosine kinase in signalling by the Fc epsilon RI antigen receptor

31 March 2020

1 reference

Sphingosine 1-phosphate: a Ca2+ release mediator in the balance

31 March 2020

1 reference

Ceramide 1-phosphate acts as a positive allosteric activator of group IVA cytosolic phospholipase A2 alpha and enhances the interaction of the enzyme with phosphatidylcholine.

31 March 2020

1 reference

Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling

31 March 2020

1 reference

Properties of the Group IV phospholipase A2 family

31 March 2020

1 reference

Treatment of inflammatory diseases by selective eicosanoid inhibition: a double-edged sword?

31 March 2020

1 reference

A glance at G-protein-coupled receptors for lipid mediators: a growing receptor family with remarkably diverse ligands

31 March 2020

1 reference

Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology

31 March 2020

1 reference

The multiple roles of PTEN in tumor suppression

31 March 2020

1 reference

Pten, tumorigenesis, and stem cell self-renewal

31 March 2020

1 reference

Phosphoinositide 3-kinase in disease: timing, location, and scaffolding

31 March 2020

1 reference

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

31 March 2020

1 reference

Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity

31 March 2020

1 reference

High frequency of mutations of the PIK3CA gene in human cancers

31 March 2020

1 reference

Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit

31 March 2020

1 reference

PKB binding proteins. Getting in on the Akt.

31 March 2020

1 reference

AKT/PKB signaling: navigating downstream

31 March 2020

1 reference

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

31 March 2020

1 reference

Defining the role of mTOR in cancer

31 March 2020

1 reference

Role of membrane sphingomyelin and ceramide in platform formation for Fas-mediated apoptosis

31 March 2020

1 reference

Ceramide 1-phosphate/ceramide, a switch between life and death.

31 March 2020

1 reference

Sphingosine-dependent apoptosis: a unified concept based on multiple mechanisms operating in concert

31 March 2020

1 reference

Ceramide-1-phosphate promotes cell survival through activation of the phosphatidylinositol 3-kinase/protein kinase B pathway

31 March 2020

1 reference

Insulin resistance and atherosclerosis

31 March 2020

1 reference

Critical nodes in signalling pathways: insights into insulin action

31 March 2020

1 reference

IRS proteins and the common path to diabetes

31 March 2020

1 reference

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

31 March 2020

1 reference

Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1.

31 March 2020

1 reference

Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver

31 March 2020

1 reference

Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis

31 March 2020

1 reference

PPARgamma : a nuclear regulator of metabolism, differentiation, and cell growth

31 March 2020

1 reference

Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein

31 March 2020

1 reference

Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes

31 March 2020

1 reference

Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2

31 March 2020

1 reference

Ceramides in insulin resistance and lipotoxicity

31 March 2020

1 reference

Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells

31 March 2020

1 reference

Enrichment of endoplasmic reticulum with cholesterol inhibits sarcoplasmic-endoplasmic reticulum calcium ATPase-2b activity in parallel with increased order of membrane lipids: implications for depletion of endoplasmic reticulum calcium stores and a

31 March 2020

1 reference

The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

31 March 2020

1 reference

Signal integration in the endoplasmic reticulum unfolded protein response

31 March 2020

1 reference

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

31 March 2020

1 reference

Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway

31 March 2020

1 reference

Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha

31 March 2020

1 reference

Increased oxidative stress in obesity and its impact on metabolic syndrome

31 March 2020

1 reference

Reactive oxygen species have a causal role in multiple forms of insulin resistance

31 March 2020

1 reference

Mitochondrial dysfunction and type 2 diabetes

31 March 2020

1 reference

Inflammation and metabolic disorders

31 March 2020

1 reference

Obesity is associated with macrophage accumulation in adipose tissue

31 March 2020

1 reference

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

31 March 2020

1 reference

Inflammation and insulin resistance

31 March 2020

1 reference

Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

31 March 2020

1 reference

Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function

31 March 2020

1 reference

Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice.

31 March 2020

1 reference

Influence of TNF-alpha and IL-6 infusions on insulin sensitivity and expression of IL-18 in humans

31 March 2020

1 reference

Innate immunity: an overview

31 March 2020

1 reference

Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4.

31 March 2020

1 reference

TLR4 links innate immunity and fatty acid-induced insulin resistance

31 March 2020

1 reference

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

31 March 2020

1 reference

Nuclear receptors and lipid physiology: opening the X-files

31 March 2020

1 reference

Combinatorial roles of nuclear receptors in inflammation and immunity

31 March 2020

1 reference

The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

31 March 2020

1 reference

Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.

31 March 2020

1 reference

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade

31 March 2020

1 reference

IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

31 March 2020

1 reference

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

31 March 2020

1 reference

A central role for JNK in obesity and insulin resistance

31 March 2020

1 reference

Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis

31 March 2020

1 reference

Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide

31 March 2020

1 reference

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

31 March 2020

1 reference

PKC-theta knockout mice are protected from fat-induced insulin resistance

31 March 2020

1 reference

Signal transduction by tumor necrosis factor and its relatives

31 March 2020

1 reference

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

31 March 2020

1 reference

Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2

31 March 2020

1 reference

Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression

31 March 2020

1 reference

Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

31 March 2020

1 reference

Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction

31 March 2020

1 reference

Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration

31 March 2020

1 reference

PI3Kgamma inhibition: towards an 'aspirin of the 21st century'?

31 March 2020

1 reference

Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.

31 March 2020

1 reference

Class IB-phosphatidylinositol 3-kinase (PI3K) deficiency ameliorates IA-PI3K-induced systemic lupus but not T cell invasion

31 March 2020

1 reference

Inhibition of phosphoinositide 3-kinase delta attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model

31 March 2020

1 reference

Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function

31 March 2020

1 reference

PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects

31 March 2020

1 reference

Phosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury

31 March 2020

1 reference

Oral fingolimod (FTY720) for relapsing multiple sclerosis

31 March 2020

1 reference

Fingolimod and sphingosine-1-phosphate--modifiers of lymphocyte migration

31 March 2020

1 reference

Multiple sclerosis: new insights and therapeutic progress.

31 March 2020

1 reference

FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis

31 March 2020

1 reference

Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses

31 March 2020

1 reference

Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo.

31 March 2020

1 reference

Tipping the gatekeeper: S1P regulation of endothelial barrier function

31 March 2020

1 reference

Inhibitors of secretory phospholipase A2 group IIA.

31 March 2020

1 reference

Risk of cardiovascular events and rofecoxib: cumulative meta-analysis

31 March 2020

1 reference

Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases

31 March 2020

1 reference

Leukotriene synthesis inhibitors versus antagonists: the pros and cons

31 March 2020

1 reference

31 March 2020

1 reference

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

31 March 2020

1 reference

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

31 March 2020

1 reference

Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases.

31 March 2020

1 reference

Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitor

31 March 2020

1 reference

PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

31 March 2020

1 reference

Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages

31 March 2020

1 reference

Targeting sphingosine-1-phosphate: a novel avenue for cancer therapeutics

31 March 2020

1 reference

Antitumor activity of sphingosine kinase inhibitors

31 March 2020

1 reference

Sphingosine-1-phosphate lyase in immunity and cancer: silencing the siren

31 March 2020

1 reference

Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer

31 March 2020

1 reference

FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia

31 March 2020

1 reference

Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina.

31 March 2020

1 reference

An emerging role for endothelial nitric oxide synthase in chronic inflammation and cancer

31 March 2020

1 reference

Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes

31 March 2020

1 reference

Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor

31 March 2020

1 reference

Inhibition of PKC beta by oral administration of ruboxistaurin is well tolerated and ameliorates diabetes-induced retinal hemodynamic abnormalities in patients

31 March 2020

1 reference

Protein kinase C deficiency increases fatty acid oxidation and reduces fat storage

31 March 2020

1 reference

Prostaglandins and leukotrienes: advances in eicosanoid biology

31 March 2020

1 reference

Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways

31 March 2020

1 reference

The phosphoinositide 3-kinase pathway

31 March 2020

1 reference

Neutral sphingomyelinases and nSMase2: bridging the gaps

31 March 2020

1 reference

Sphingolipids and cell death.

31 March 2020

1 reference

Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases

31 March 2020

1 reference

The nuclear receptor superfamily: the second decade

31 March 2020

1 reference

The mechanisms of action of PPARs

31 March 2020

1 reference

Phosphatidylinositol (3,4,5)-trisphosphate specifically interacts with the phox homology domain of phospholipase D1 and stimulates its activity

31 March 2020

1 reference

Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRM2335

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18216772%20AND%20SRC:MED&resulttype=core&format=json

release_an2pxcizsfanrfogb3fa4si6rq

1 January 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/an2pxcizsfanrfogb3fa4si6rq

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference