Dual-Specificity Phosphatase CDC25A/B Inhibitor Identified from a Focused Library with Nonelectrophilic Core Structure (Q34233935)

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29 January 2020

title

Dual-Specificity Phosphatase CDC25A/B Inhibitor Identified from a Focused Library with Nonelectrophilic Core Structure (English)

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29 January 2020

2

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Mikiko Sodeoka

7

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29 January 2020

author name string

Ayako Tsuchiya

1

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29 January 2020

Yusuke Koyama

3

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29 January 2020

Kana Oonuma

4

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Yuko Otani

5

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29 January 2020

Hiroyuki Osada

6

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29 January 2020

publication date

15 February 2012

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ACS Medicinal Chemistry Letters

29 January 2020

published in

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29 January 2020

volume

3

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issue

4

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29 January 2020

page(s)

294-298

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Development of a Vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure

29 January 2020

cites work

1 reference

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LGH00031, a novel ortho-quinonoid inhibitor of cell division cycle 25B, inhibits human cancer cells via ROS generation

6 July 2018

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Cell cycle, CDKs and cancer: a changing paradigm

6 July 2018

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IRC-083864, a novel bis quinone inhibitor of CDC25 phosphatases active against human cancer cells

6 July 2018

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CDC25 phosphatases in cancer cells: key players? Good targets?

6 July 2018

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What's new on CDC25 phosphatase inhibitors

6 July 2018

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H32, a non-quinone sulfone analog of vitamin K3, inhibits human hepatoma cell growth by inhibiting Cdc25 and activating ERK.

6 July 2018

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Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence

6 July 2018

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Inhibitors of protein tyrosine phosphatases: next-generation drugs?

6 July 2018

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Halenaquinone and xestoquinone derivatives, inhibitors of Cdc25B phosphatase from a Xestospongia sp.

6 July 2018

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Cdc25 phosphatases and cancer

6 July 2018

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Redox regulation of PTEN and protein tyrosine phosphatases in H(2)O(2) mediated cell signaling

6 July 2018

1 reference

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Binding and inhibition of Cdc25 phosphatases by vitamin K analogues

6 July 2018

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Dual-specificity phosphatases as targets for antineoplastic agents

6 July 2018

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Dual G1 and G2 phase inhibition by a novel, selective Cdc25 inhibitor 6-chloro-7-[corrected](2-morpholin-4-ylethylamino)-quinoline-5,8-dione

6 July 2018

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Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25.

6 July 2018

1 reference

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Synthesis of a tetronic acid library focused on inhibitors of tyrosine and dual-specificity protein phosphatases and its evaluation regarding VHR and cdc25B inhibition

6 July 2018

1 reference

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The FT210 cell line is a mouse G2 phase mutant with a temperature-sensitive CDC2 gene product

6 July 2018

1 reference

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Redox regulation of Cdc25B by cell-active quinolinediones

6 July 2018

1 reference

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Structural mechanism of oxidative regulation of the phosphatase Cdc25B via an intramolecular disulfide bond

28 October 2018

1 reference

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Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors

28 October 2018

1 reference

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Isolation and analysis of a mammalian temperature-sensitive mutant defective in G2 functions

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22506091

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ML2002778

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29 January 2020

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29 January 2020

PubMed publication ID

22506091

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22506091%20AND%20SRC:MED&resulttype=core&format=json