Proinsulin atypical maturation and disposal induces extensive defects in mouse Ins2+/Akita β-cells (Q34235559)

31 July 2017

Proinsulin atypical maturation and disposal induces extensive defects in mouse Ins2+/Akita β-cells (English)

1 reference

31 July 2017

Qingxin Yuan

1

1 reference

31 July 2017

Wei Tang

2

1 reference

31 July 2017

Xiaoping Zhang

3

1 reference

31 July 2017

Jack A Hinson

4

1 reference

31 July 2017

Chao Liu

5

1 reference

31 July 2017

Kwame Osei

6

1 reference

31 July 2017

Jie Wang

7

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31 July 2017

language of work or name

English

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publication date

3 April 2012

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31 July 2017

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31 July 2017

7

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31 July 2017

4

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31 July 2017

e35098

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Creative Commons Attribution 4.0 International

31 July 2017

start time

3 April 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3318013/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Control of precursor maturation and disposal is an early regulative mechanism in the normal insulin production of pancreatic β-cells

28 July 2018

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Proinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth

28 July 2018

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28 July 2018

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Enhanced signaling downstream of ribonucleic Acid-activated protein kinase-like endoplasmic reticulum kinase potentiates lipotoxic endoplasmic reticulum stress in human islets.

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes

28 July 2018

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28 July 2018

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Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodeling

28 July 2018

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Insulin gene mutations as a cause of permanent neonatal diabetes

28 July 2018

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28 July 2018

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Gliclazide protects human islet beta-cells from apoptosis induced by intermittent high glucose

28 July 2018

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Pancreatic beta cells lack a low glucose and O2-inducible mitochondrial protein that augments cell survival

28 July 2018

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Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities

28 July 2018

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Five stages of evolving beta-cell dysfunction during progression to diabetes

28 July 2018

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The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP1 in Ins2+/Akita pancreatic beta cells.

28 July 2018

1 reference

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Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes

28 July 2018

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Lipoapoptosis: its mechanism and its diseases

28 July 2018

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Apoptosis in hypoxic human pancreatic islets correlates with HIF-1alpha expression

28 July 2018

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Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes

28 July 2018

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Phasic insulin release and metabolic regulation in type 2 diabetes.

28 July 2018

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Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion

28 July 2018

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High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program

28 July 2018

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Beta-cell maturation leads to in vitro sensitivity to cytotoxins

28 July 2018

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Proteolytic processing in the secretory pathway

28 July 2018

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Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

28 July 2018

1 reference

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A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse

28 July 2018

1 reference

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Mapping of murine diabetogenic gene mody on chromosome 7 at D7Mit258 and its involvement in pancreatic islet and beta cell development during the perinatal period

28 July 2018

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Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells

28 July 2018

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Development of autoimmune diabetes in NOD mice is associated with the formation of peroxynitrite in pancreatic islet beta-cells.

28 July 2018

1 reference

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Redox regulation of NF-kappa B activation

28 July 2018

1 reference

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Studies in the diabetic mutant mouse. II. Electron microscopy of pancreatic islets

28 July 2018

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Evidence for an inhibitor of insulin release in the pancreatic islets

28 July 2018

1 reference

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Insulin biosynthesis: studies of Islet polyribosomes (nascent peptides-sucrose gradient analysis-gel filtration).

28 July 2018

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Influence of the mutation "diabetes" on insulin release and islet morphology in mice of different genetic backgrounds

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318013

{beta}-Cell mass dynamics and islet cell plasticity in human type 2 diabetes.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318013

Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318013

The replication of beta cells in normal physiology, in disease and for therapy

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318013

Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318013

Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318013

Type 2 diabetes-a matter of beta-cell life and death?

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318013

Misfolded proinsulin accumulates in expanded pre-Golgi intermediates and endoplasmic reticulum subdomains in pancreatic beta cells of Akita mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318013

Prolonged culture in low glucose induces apoptosis of rat pancreatic beta-cells through induction of c-myc.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318013

Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318013

Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318013

Proinsulin maturation disorder is a contributor to the defect of subsequent conversion to insulin in β-cells

28 October 2018

1 reference

12 December 2020

Biosynthesis of proinsulin of carp (Cyprinus carpio) and characterization and cloning of mRNA

1 reference

12 December 2020

A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice

1 reference

12 December 2020

Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat

1 reference

12 December 2020

Effect of Alloxan on the Insulin Content of Micro-dissected Mammalian Pancreatic Islets

1 reference

12 December 2020

Western blot analysis for nitrotyrosine protein adducts in livers of saline-treated and acetaminophen-treated mice

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0035098

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DOI

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31 July 2017

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31 July 2017

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