V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors (Q34248395)

31 July 2017

title

V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors (English)

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31 July 2017

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O M Grbovic

1

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31 July 2017

A D Basso

2

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31 July 2017

A Sawai

3

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31 July 2017

Q Ye

4

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31 July 2017

P Friedlander

5

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31 July 2017

D Solit

6

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31 July 2017

N Rosen

7

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31 July 2017

language of work or name

English

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publication date

21 December 2005

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Proceedings of the National Academy of Sciences of the United States of America

31 July 2017

published in

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31 July 2017

volume

103

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31 July 2017

issue

1

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31 July 2017

page(s)

57-62

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Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors

31 July 2017

cites work

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Suppression of oncogenic NRAS by RNA interference induces apoptosis of human melanoma cells.

6 July 2018

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MEK inhibitors: a therapeutic approach to targeting the Ras-MAP kinase pathway in tumors

6 July 2018

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V599EB-RAF is an oncogene in melanocytes

6 July 2018

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Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

6 July 2018

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6 July 2018

Heat shock protein 90.

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17-Allylamino-17-demethoxygeldanamycin (17-AAG) is effective in down-regulating mutated, constitutively activated KIT protein in human mast cells

6 July 2018

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Overview: Translating Hsp90 Biology into Hsp90 Drugs

6 July 2018

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Raf proteins and cancer: B-Raf is identified as a mutational target

6 July 2018

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High frequency of BRAF mutations in nevi

6 July 2018

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Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

6 July 2018

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6 July 2018

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HSP90 as a new therapeutic target for cancer therapy: the story unfolds

6 July 2018

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Discovery of a novel Raf kinase inhibitor

6 July 2018

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The heat shock protein 90 antagonist geldanamycin alters chaperone association with p210bcr-abl and v-src proteins before their degradation by the proteasome

6 July 2018

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p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function

6 July 2018

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The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

6 July 2018

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Geldanamycin-induced destabilization of Raf-1 involves the proteasome

6 July 2018

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Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin

6 July 2018

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Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

6 July 2018

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Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4

6 July 2018

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Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

6 July 2018

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Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies

6 July 2018

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Frequent alterations of Ras signaling pathway genes in sporadic malignant melanomas

28 October 2018

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Flow cytometric analysis of G1- and G2/M-phase subpopulations in mammalian cell nuclei using side scatter and DNA content measurements

28 October 2018

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Screening of N-ras codon 61 mutations in paired primary and metastatic cutaneous melanomas: mutations occur early and persist throughout tumor progression

28 October 2018

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12 December 2020

BRAF and RAS mutations in human lung cancer and melanoma

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12 December 2020

Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation

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12 December 2020

BRAF Mutation in Papillary Thyroid Carcinoma

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12 December 2020

Suppression of BRAF(V599E) in human melanoma abrogates transformation

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12 December 2020

Identifiers

DOI

10.1073/PNAS.0609973103

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31 July 2017

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31 July 2017

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