Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis (Q34253185)

31 July 2017

title

Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis (English)

1 reference

31 July 2017

David Dankort

9

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Daniel Peeper

12

object named as

Daniel S Peeper

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31 July 2017

author name string

Liesbeth C W Vredeveld

1

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31 July 2017

Patricia A Possik

2

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31 July 2017

Marjon A Smit

3

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31 July 2017

Katrin Meissl

4

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31 July 2017

Chrysiis Michaloglou

5

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31 July 2017

Hugo M Horlings

6

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31 July 2017

Abderrahim Ajouaou

7

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31 July 2017

Pim C Kortman

8

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31 July 2017

Martin McMahon

10

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31 July 2017

Wolter J Mooi

11

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31 July 2017

publication date

1 May 2012

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31 July 2017

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31 July 2017

volume

26

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31 July 2017

issue

10

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31 July 2017

page(s)

1055-1069

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Reversing melanoma cross-resistance to BRAF and MEK inhibitors by co-targeting the AKT/mTOR pathway.

31 July 2017

cites work

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6 July 2018

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6 July 2018

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6 July 2018

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Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Oncogenic Braf induces melanocyte senescence and melanoma in mice

6 July 2018

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Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma

6 July 2018

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Braf(V600E) cooperates with Pten loss to induce metastatic melanoma

6 July 2018

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Oncogene-induced senescence does not require the p16(INK4a) or p14ARF melanoma tumor suppressors.

6 July 2018

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RAS and RAF mutations in banal melanocytic aggregates contiguous with primary cutaneous melanoma: clues to melanomagenesis

6 July 2018

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A novel AKT3 mutation in melanoma tumours and cell lines

6 July 2018

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Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development.

6 July 2018

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6 July 2018

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A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors

6 July 2018

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Oncogene-induced cell senescence--halting on the road to cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360561

Congenital melanocytic nevi frequently harbor NRAS mutations but no BRAF mutations

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360561

Cellular senescence in naevi and immortalisation in melanoma: a role for p16?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360561

6 July 2018

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Distinct sets of genetic alterations in melanoma

6 July 2018

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Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

6 July 2018

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BRAFE600-associated senescence-like cell cycle arrest of human naevi

6 July 2018

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Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360561

Deregulated Akt3 activity promotes development of malignant melanoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360561

Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360561

Mutations of the BRAF gene in benign and malignant melanocytic lesions

6 July 2018

1 reference

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Human melanocyte senescence and melanoma susceptibility genes

6 July 2018

1 reference

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Melanoma ex naevo: a study of the associated naevus

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360561

PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360561

High frequency of BRAF mutations in nevi

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360561

Mutations of the BRAF gene in human cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360561

Epigenetic PTEN silencing in malignant melanomas without PTEN mutation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360561

Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360561

Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360561

A cell cycle regulator potentially involved in genesis of many tumor types

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360561

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360561

Detection of a low frequency of activated ras genes in human melanomas using a tumorigenicity assay

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360561

N-ras mutations in human cutaneous melanoma from sun-exposed body sites.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360561

Association of early malignant melanoma with nevocytic nevi

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360561

Targeting melanoma with dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360561

A negative feedback signaling network underlies oncogene-induced senescence

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360561

Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360561

Prognostic significance of activated Akt expression in melanoma: a clinicopathologic study of 292 cases

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360561

BRAF alterations are associated with complex mutational profiles in malignant melanoma

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360561

Homozygous germline mutation of CDKN2A/p16 and glucose-6-phosphate dehydrogenase deficiency in a multiple melanoma case

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360561

Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kappaB and tumor progression.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360561

Analysis of N- and K-ras mutations in the distinctive tumor progression phases of melanoma.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360561

Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360561

Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360561

Non-random spatial association of melanoma and naevi--a morphometric analysis

28 October 2018

1 reference

12 December 2020

PTEN expression in normal skin, acquired melanocytic nevi, and cutaneous melanoma

1 reference

12 December 2020

Cutaneous melanomas associated with nevi

1 reference

12 December 2020

Mutation and allelic loss of the PTEN/MMAC1 gene in primary and metastatic melanoma biopsies

1 reference

12 December 2020

Mutations of PIK3CA are rare in cutaneous melanoma

1 reference

12 December 2020

Epigenetic silencing of the PTEN gene in melanoma

1 reference

12 December 2020

Identifiers

DOI

10.1101/GAD.187252.112

1 reference

31 July 2017

1 reference

31 July 2017

1 reference