PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms (Q28181035)

1

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Andrew G Li

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Gang Wei

3

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Heng-Hong Li

4

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Nathalie Kertesz

5

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Ralf Lesche

6

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Andrew D Whale

7

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Hilda Martinez-Diaz

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Nora Rozengurt

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Xuan Liu

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Hong Wu

Delayed mammary gland involution in MMTV-AKT1 transgenic mice

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language of work or name

English

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publication date

February 2003

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published in

Cancer Cell

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volume

3

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issue

2

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page(s)

117-30

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cites work

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Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway

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Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

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Distinct sets of gene alterations in endometrial carcinoma implicate alternate modes of tumorigenesis

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Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas

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Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association

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Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice

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Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

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Hormone-dependent, CARM1-directed, arginine-specific methylation of histone H3 on a steroid-regulated promoter

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Insights into cancer from transgenic mouse models

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

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PTEN and myotubularin: novel phosphoinositide phosphatases

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Tumor induction by an Lck-MyrAkt transgene is delayed by mechanisms controlling the size of the thymus

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Allelic imbalance, including deletion of PTEN/MMACI, at the Cowden disease locus on 10q22-23, in hamartomas from patients with Cowden syndrome and germline PTEN mutation

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A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

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PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy

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The lipid phosphatase activity of PTEN is critical for its tumor supressor function

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Akt enhances Mdm2-mediated ubiquitination and degradation of p53.

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

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Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB.

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PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

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High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

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The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

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Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation

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HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

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RETRACTED: Pretreatment with oral clonidine attenuates cardiovascular responses to tracheal extubation in children.

1 reference

11 February 2024

https://opencitations.net/index/api/v1/citations/10.1046/J.1460-9592.2000.00441.X

Identifiers

DOI

10.1016/S1535-6108(03)00021-7

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

12620407

1 reference

Consolidated OpenCitations Corpus – April 2017