Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction (Q24650734)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18468463%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

title

Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction (English)

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7 January 2020

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5

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7 January 2020

Benoit L Salomon

8

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7 January 2020

author name string

Qizhi Tang

1

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7 January 2020

Jason Y Adams

2

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7 January 2020

Cristina Penaranda

3

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7 January 2020

Kristin Melli

4

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7 January 2020

Evridiki Sgouroudis

6

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7 January 2020

Ciriaco A Piccirillo

7

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7 January 2020

Jeffrey A Bluestone

9

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7 January 2020

language of work or name

English

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publication date

8 May 2008

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7 January 2020

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7 January 2020

volume

28

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7 January 2020

page(s)

687-697

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7 January 2020

issue

5

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Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

7 January 2020

cites work

1 reference

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Where CD4+CD25+ T reg cells impinge on autoimmune diabetes

7 April 2017

1 reference

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Regulatory T cell lineage specification by the forkhead transcription factor foxp3

7 April 2017

1 reference

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Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

7 April 2017

1 reference

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Multiple immuno-regulatory defects in type-1 diabetes

7 April 2017

1 reference

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B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

7 April 2017

1 reference

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Breeding of a non-obese, diabetic strain of mice

7 April 2017

1 reference

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A function for interleukin 2 in Foxp3-expressing regulatory T cells

7 April 2017

1 reference

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CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells

7 April 2017

1 reference

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Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation.

28 September 2017

1 reference

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Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity

28 September 2017

1 reference

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Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals.

28 September 2017

1 reference

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The tumor-draining lymph node as an immune-privileged site

28 September 2017

1 reference

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Clearance of apoptotic and necrotic cells and its immunological consequences

28 September 2017

1 reference

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The role of regulatory T cells in alloantigen tolerance

28 September 2017

1 reference

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Infectious tolerance and the long-term acceptance of transplanted tissue

28 September 2017

1 reference

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Natural regulatory T cells and parasites: a common quest for host homeostasis

28 September 2017

1 reference

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Regulatory T cells in virus infections

28 September 2017

1 reference

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Regulatory T-cell physiology and application to treat autoimmunity

28 September 2017

1 reference

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Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394854

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394854

Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394854

Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling

28 September 2017

1 reference

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Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

28 September 2017

1 reference

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Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes

28 September 2017

1 reference

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The NOD mouse: a model of immune dysregulation

28 September 2017

1 reference

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Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors

28 September 2017

1 reference

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Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

28 September 2017

1 reference

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Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes.

28 September 2017

1 reference

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Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells.

28 September 2017

1 reference

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In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes

28 September 2017

1 reference

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Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells

28 September 2017

1 reference

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Physiological β Cell Death Triggers Priming of Self-reactive T Cells by Dendritic Cells in a Type-1 Diabetes Model

28 September 2017

1 reference

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CD3 antibody treatment stimulates the functional capability of regulatory T cells

28 September 2017

1 reference

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Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancer

28 September 2017

1 reference

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Autoimmunity in Wiskott-Aldrich syndrome: risk factors, clinical features, and outcome in a single-center cohort of 55 patients

28 September 2017

1 reference

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CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

28 September 2017

1 reference

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Interleukin 2 signaling is required for CD4(+) regulatory T cell function

28 September 2017

1 reference

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Autoimmunity in human primary immunodeficiency diseases

28 September 2017

1 reference

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Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394854

Germ line deletion of the CD1 locus exacerbates diabetes in the NOD mouse

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394854

A novel role of metalloproteinase in cancer-mediated immunosuppression.

28 September 2017

1 reference

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Interleukin-2 deficient mice: a new model to study autoimmunity and self-tolerance

28 September 2017

1 reference

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Structure and expression of a cloned cDNA for human interleukin-2.

28 September 2017

1 reference

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HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394854

Selective stimulation of T cell subsets with antibody-cytokine immune complexes.

30 May 2018

1 reference

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Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells.

28 November 2018

1 reference

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Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

28 November 2018

1 reference

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Combination therapy with sirolimus and interleukin-2 prevents spontaneous and recurrent autoimmune diabetes in NOD mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394854

Mapping of the IDDM locus Idd3 to a 0.35-cM interval containing the interleukin-2 gene.

28 November 2018

1 reference

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Genetic analysis of immune dysfunction in non-obese diabetic (NOD) mice: Mapping of a susceptibility locus close to theBcl-2 gene correlates with increased resistance of NOD T cells to apoptosis induction

28 November 2018

1 reference

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BCG vaccination prevents insulin-dependent diabetes mellitus (IDDM) in NOD mice after disease acceleration with cyclophosphamide

28 November 2018

1 reference

12 December 2020

Activation of natural killer T cells by alpha-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes

1 reference

12 December 2020

Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes

1 reference

12 December 2020

Overexpression of bcl-2 in T cells affects insulitis in the nonobese diabetic mouse

1 reference

12 December 2020

Dynamics of pathogenic and suppressor T cells in autoimmune diabetes development

1 reference

12 December 2020

Three recessive loci required for insulin-dependent diabetes in nonobese diabetic mice

1 reference

12 December 2020

Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice

1 reference

12 December 2020

CD4+CD25high regulatory T cells in human autoimmune diabetes

1 reference

12 December 2020

Interleukin-2 administration alters the CD4+FOXP3+ T-cell pool and tumor trafficking in patients with ovarian carcinoma

1 reference

12 December 2020

Long-term survival update for high-dose recombinant interleukin-2 in patients with renal cell carcinoma

1 reference

12 December 2020

Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes

1 reference

12 December 2020

10.1016/J.IMMUNI.2008.03.016

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18468463%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18468463%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

2 references