Repurposing cAMP-modulating medications to promote β-cell replication. (Q34265051)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25083741%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

title

Repurposing cAMP-modulating medications to promote β-cell replication (English)

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10

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author name string

Zhenshan Zhao

1

1 reference

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11 March 2020

Yen S Low

2

1 reference

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11 March 2020

Neali A Armstrong

3

1 reference

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11 March 2020

Jennifer Hyoje Ryu

4

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11 March 2020

Sara A Sun

5

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11 March 2020

Anthony C Arvanites

6

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Jennifer Hollister-Lock

7

1 reference

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Nigam H Shah

8

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Gordon C Weir

9

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11 March 2020

publication date

1 August 2014

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11 March 2020

published in

Molecular Endocrinology

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11 March 2020

volume

28

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issue

10

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11 March 2020

page(s)

1682-1697

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Targeting the cell cycle inhibitor p57Kip2 promotes adult human β cell replication.

11 March 2020

cites work

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Adult tissue sources for new β cells.

6 July 2018

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Osteocalcin promotes β-cell proliferation during development and adulthood through Gprc6a

6 July 2018

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β-Cell-specific protein kinase A activation enhances the efficiency of glucose control by increasing acute-phase insulin secretion

6 July 2018

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6 July 2018

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6 July 2018

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Overexpression of hepatocyte nuclear factor-4α initiates cell cycle entry, but is not sufficient to promote β-cell expansion in human islets

6 July 2018

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Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replication

6 July 2018

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Stimulating β-cell replication and improving islet graft function by AR231453, A GPR119 agonist

6 July 2018

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Skp2 is required for incretin hormone-mediated β-cell proliferation

6 July 2018

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Id3 upregulates BrdU incorporation associated with a DNA damage response, not replication, in human pancreatic β-cells

6 July 2018

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Variants of ADRA2A are associated with fasting glucose, blood pressure, body mass index and type 2 diabetes risk: meta-analysis of four prospective studies

6 July 2018

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Expression and regulation of cyclic nucleotide phosphodiesterases in human and rat pancreatic islets

6 July 2018

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Parathyroid hormone-related protein enhances human ß-cell proliferation and function with associated induction of cyclin-dependent kinase 2 and cyclin E expression

6 July 2018

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Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain.

6 July 2018

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Cyclic AMP signaling in pancreatic islets

6 July 2018

1 reference

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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

6 July 2018

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Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes

6 July 2018

1 reference

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Glucose tolerance in depressed inpatients, under treatment with mirtazapine and in healthy controls.

6 July 2018

1 reference

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Phosphodiesterase 10A inhibitor activity in preclinical models of the positive, cognitive, and negative symptoms of schizophrenia

6 July 2018

1 reference

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Phosphodiesterase 3 and 4 comprise the major cAMP metabolizing enzymes responsible for insulin secretion in INS-1 (832/13) cells and rat islets

6 July 2018

1 reference

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Exendin-4 stimulation of cyclin A2 in beta-cell proliferation

6 July 2018

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Imaging cyclic AMP changes in pancreatic islets of transgenic reporter mice

6 July 2018

1 reference

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Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans

6 July 2018

1 reference

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Beta cell-specific deficiency of the stimulatory G protein alpha-subunit Gsalpha leads to reduced beta cell mass and insulin-deficient diabetes.

6 July 2018

1 reference

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Increasing GLP-1-induced beta-cell proliferation by silencing the negative regulators of signaling cAMP response element modulator-alpha and DUSP14.

6 July 2018

1 reference

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Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion.

6 July 2018

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Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells

6 July 2018

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Overview of PDEs and their regulation

6 July 2018

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Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion

6 July 2018

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Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice

6 July 2018

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Increased pancreatic beta-cell proliferation mediated by CREB binding protein gene activation

6 July 2018

1 reference

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Exendin-4 induction of cyclin D1 expression in INS-1 beta-cells: involvement of cAMP-responsive element

6 July 2018

1 reference

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Stimulation of pancreatic beta-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways.

6 July 2018

1 reference

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Oscillations of cyclic AMP in hormone-stimulated insulin-secreting beta-cells

6 July 2018

1 reference

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Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth

6 July 2018

1 reference

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Targeting beta-cell cyclic 3'5' adenosine monophosphate for the development of novel drugs for treating type 2 diabetes mellitus. A review

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4179632

Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4179632

Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4179632

Overexpression of inducible cyclic AMP early repressor inhibits transactivation of genes and cell proliferation in pancreatic beta cells

6 July 2018

1 reference

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Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes

6 July 2018

1 reference

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Prolactin, progesterone, and dexamethasone coordinately and adversely regulate glucokinase and cAMP/PDE cascades in MIN6 β-cells

6 July 2018

1 reference

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Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4179632

cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4179632

PTHrP increases pancreatic beta-cell-specific functions in well-differentiated cells

6 July 2018

1 reference

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Autonomic regulation of islet hormone secretion--implications for health and disease

6 July 2018

1 reference

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Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors

6 July 2018

1 reference

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Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4179632

Adaptation of islets of Langerhans to pregnancy: beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones

6 July 2018

1 reference

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Expression of alpha 2- and beta-adrenoceptor subtypes in human islets of Langerhans

6 July 2018

1 reference

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Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37).

6 July 2018

1 reference

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The homeodomain protein IPF-1/STF-1 is expressed in a subset of islet cells and promotes rat insulin 1 gene expression dependent on an intact E1 helix-loop-helix factor binding site.

6 July 2018

1 reference

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Mechanism of action of dipyridamole

6 July 2018

1 reference

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Cyclic Adenosine-3′,5′ -monophosphate Stimulates Islet B Cell Replication in Neonatal Rat Pancreatic Monolayer Cultures

6 July 2018

1 reference

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Effects of pregnancy in the rat on the size and insulin secretory response of the islets of Langerhans

6 July 2018

1 reference

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Expression of both alpha 1- and alpha 2-adrenoceptors in an insulin-secreting cell line. Parallel studies of cytosolic free Ca2+ and insulin release.

6 July 2018

1 reference

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A morphological study of the endocrine pancreas in human pregnancy

6 July 2018

1 reference

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Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes

6 July 2018

1 reference

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Genetic deletion and pharmacological inhibition of phosphodiesterase 10A protects mice from diet-induced obesity and insulin resistance

28 October 2018

1 reference

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Adenosine signaling promotes regeneration of pancreatic β cells in vivo

28 October 2018

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Control of pancreatic β cell regeneration by glucose metabolism.

28 October 2018

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Pancreatic beta-cell mass in European subjects with type 2 diabetes

28 October 2018

1 reference

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Growth and regeneration of adult beta cells does not involve specialized progenitors.

28 October 2018

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Relationship between beta-cell mass and fasting blood glucose concentration in humans

28 October 2018

1 reference

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Altered glucose homeostasis in alpha2A-adrenoceptor knockout mice

28 October 2018

1 reference

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Effects of phosphodiesterase 3,4,5 inhibitors on hepatocyte cAMP levels, glycogenolysis, gluconeogenesis and susceptibility to a mitochondrial toxin

28 October 2018

1 reference

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Compensatory Growth of Pancreatic -Cells in Adult Rats After Short-Term Glucose Infusion

28 October 2018

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12 December 2020

Effect of alpha-adrenergic blockade on insulin secretion in man

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12 December 2020

Effects of glucose on beta cells in pancreatic monolayer cultures

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Reproducible high yield of rat islets by stationary in vitro digestion following pancreatic ductal or portal venous collagenase injection

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12 December 2020

Identifiers

DOI

10.1210/ME.2014-1120

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25083741%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25083741%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25083741%20AND%20SRC:MED&resulttype=core&format=json