The protein kinase activity modulation sites: mechanisms for cellular regulation - targets for therapeutic intervention (Q34268736)

1 August 2017

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title

The protein kinase activity modulation sites: mechanisms for cellular regulation - targets for therapeutic intervention (English)

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1 August 2017

Engh RA

1

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PubMed ID

11384741

1 August 2017

Bossemeyer D

series ordinal

2

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1 August 2017

1 January 2001

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Advances in Enzyme Regulation

1 August 2017

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1 August 2017

41

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1 August 2017

121-149

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1 August 2017

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Structures of staurosporine bound to CDK2 and cAPK--new tools for structure-based design of protein kinase inhibitors

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Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

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Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor

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Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase

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The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition

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Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

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Protein modification: docking sites for kinases

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Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members

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Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity

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The glycine-rich sequence of protein kinases: a multifunctional element

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A binary complex of the catalytic subunit of cAMP-dependent protein kinase and adenosine further defines conformational flexibility

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Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformations

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Active and inactive protein kinases: structural basis for regulation

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In vivo activation of recombinant cAPK catalytic subunit active site mutants by coexpression of the wild-type enzyme, evidence for intermolecular cotranslational phosphorylation

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7 January 2021

Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase

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7 January 2021

Dephosphorylation of catalytic subunit of cAMP-dependent protein kinase at Thr-197 by a cellular protein phosphatase and by purified protein phosphatase-2A

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Phosphorylation modulates catalytic function and regulation in the cAMP-dependent protein kinase

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The Eleventh Datta Lecture. The structural basis for substrate recognition and control by protein kinases

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Crystal structure of the tyrosine kinase domain of the human insulin receptor

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Crystal structure of cyclin-dependent kinase 2

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Regulation of CDKs by phosphorylation.

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Effects of phosphorylation of threonine 160 on cyclin-dependent kinase 2 structure and activity

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Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors

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The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases

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Structural basis of cyclin-dependent kinase activation by phosphorylation

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7 January 2021

Kinetic analyses of mutations in the glycine-rich loop of cAMP-dependent protein kinase.

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Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex

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Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d

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Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1

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Cyclin-dependent kinase and Cks/Suc1 interact with the proteasome in yeast to control proteolysis of M-phase targets

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Structure-function relationships in Src family and related protein tyrosine kinases

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Crystal structures of c-Src reveal features of its autoinhibitory mechanism

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Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

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The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions

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Three-dimensional structure of the tyrosine kinase c-Src

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7 January 2021

Crystal structure of the Src family tyrosine kinase Hck

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7 January 2021

Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor

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Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism

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Structural basis for the autoinhibition of calcium/calmodulin-dependent protein kinase I

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Insights into autoregulation from the crystal structure of twitchin kinase

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7 January 2021

Substrate and pseudosubstrate interactions with protein kinases: determinants of specificity

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Structural basis for activation of the titin kinase domain during myofibrillogenesis

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7 January 2021

Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase)

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7 January 2021

Crystal structure of p38 mitogen-activated protein kinase

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7 January 2021

The structure of phosphorylated p38gamma is monomeric and reveals a conserved activation-loop conformation

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Atomic structure of the MAP kinase ERK2 at 2.3 A resolution

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Activation mechanism of the MAP kinase ERK2 by dual phosphorylation

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Crystal structure of JNK3: a kinase implicated in neuronal apoptosis

1 reference

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7 January 2021

The structure of mitogen-activated protein kinase p38 at 2.1-A resolution

1 reference

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7 January 2021

Three-dimensional structure of mammalian casein kinase I: molecular basis for phosphate recognition

1 reference

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7 January 2021

Crystal structure of casein kinase-1, a phosphate-directed protein kinase

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Human casein kinase II: structures, genes, expression and requirement in cell growth stimulation

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7 January 2021

Crystal structure of the catalytic subunit of protein kinase CK2 from Zea mays at 2.1 A resolution.

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7 January 2021

GTP plus water mimic ATP in the active site of protein kinase CK2

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7 January 2021

Characterization of the regulatory domain of the gamma-subunit of phosphorylase kinase. The two noncontiguous calmodulin-binding subdomains are also autoinhibitory.

1 reference

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7 January 2021

Two structures of the catalytic domain of phosphorylase kinase: an active protein kinase complexed with substrate analogue and product

1 reference

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1 reference

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7 January 2021

Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine

1 reference

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7 January 2021

Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis

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7 January 2021

Staurosporine-induced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potential

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7 January 2021

Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2

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7 January 2021

Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors

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7 January 2021

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Identifiers

DOI

1 reference

1 August 2017

1 reference

PubMed ID

11384741