Suppressors of cytokine signaling and immunity (Q34279168)

1 August 2017

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title

Suppressors of cytokine signaling and immunity (English)

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1 August 2017

Masato Kubo

1

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1 August 2017

Toshikatsu Hanada

series ordinal

2

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1 August 2017

Akihiko Yoshimura

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3

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1 August 2017

language of work or name

English

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publication date

1 December 2003

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4

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1169-1176

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12

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Cytokine receptor signalling

1 August 2017

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7 January 2021

Cytokine signaling in 2002: new surprises in the Jak/Stat pathway

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7 January 2021

Negative regulation of cytokine signaling pathways

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7 January 2021

Suppressors of cytokine signalling (SOCS) in the immune system

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7 January 2021

Suppressors of cytokine signaling: Relevance to gastrointestinal function and disease

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Structure and function of a new STAT-induced STAT inhibitor

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A family of cytokine-inducible inhibitors of signalling

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A new protein containing an SH2 domain that inhibits JAK kinases

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7 January 2021

SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms

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Dual effects of suppressor of cytokine signaling (SOCS-2) on growth hormone signal transduction

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Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling

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Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)

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Gigantism in mice lacking suppressor of cytokine signalling-2

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Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation

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The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

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A three-dimensional model of Suppressor Of Cytokine Signalling 1 (SOCS-1).

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CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2

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Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

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SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130

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A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor

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7 January 2021

SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985

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7 January 2021

SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities

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7 January 2021

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

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The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

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The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2.

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Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation

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The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo

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Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation

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Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice

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Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.

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SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality

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SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.

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Neutralization of interferon-gamma in neonatal SOCS1-/- mice prevents fatty degeneration of the liver but not subsequent fatal inflammatory disease

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Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1).

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7 January 2021

Suppressor of Cytokine Signaling-1 Is Essential for Suppressing Dendritic Cell Activation and Systemic Autoimmunity

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7 January 2021

JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling

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Suppressor of Cytokine Signaling-1 Regulates Signaling in Response to Interleukin-2 and Other γc-dependent Cytokines in Peripheral T Cells

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Inhibition of Th1 Differentiation by IL-6 Is Mediated by SOCS1

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Negative Regulation of Interleukin-12 Signaling by Suppressor of Cytokine Signaling-1

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Suppressor of cytokine signaling 1 regulates IL-15 receptor signaling in CD8+CD44high memory T lymphocytes.

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Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha-induced cell death in fibroblasts

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SOCS1/JAB is a negative regulator of LPS-induced macrophage activation

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SOCS-1 participates in negative regulation of LPS responses

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Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation

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7 January 2021

Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation

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SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo

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The lethal effects of transplantation of Socs1-/- bone marrow cells into irradiated adult syngeneic recipients

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Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation.

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Suppressor of Cytokine Signaling-1 Has IFN- -Independent Actions in T Cell Homeostasis

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Interleukin 4 expressed in situ selectively alters thymocyte development

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CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor

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Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells

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A regulatory role for suppressor of cytokine signaling-1 in T(h) polarization in vivo

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Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation

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Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: implications for Th cell lineage commitment and maintenance

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Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3

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SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation

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SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses.

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SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation

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Cutting edge: Suppressor of cytokine signaling 3 inhibits activation of NFATp

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A role of suppressor of cytokine signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated interleukin 2 production

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7 January 2021

LPS and TNFalpha induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages.

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7 January 2021

Suppressors of cytokine signaling (SOCS)-1 and SOCS-3 are induced by CpG-DNA and modulate cytokine responses in APCs

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Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.

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IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages

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A critical role for Stat3 signaling in immune tolerance

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7 January 2021

SOCS3 regulates the plasticity of gp130 signaling

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7 January 2021

SOCS3 negatively regulates IL-6 signaling in vivo

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Ingested type I interferon: a potential treatment for autoimmunity

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7 January 2021

A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis

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Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice

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CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation

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7 January 2021

Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis

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Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice

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Cytokine-induced Src homology 2 protein (CIS) promotes T cell receptor-mediated proliferation and prolongs survival of activated T cells

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7 January 2021

SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation

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7 January 2021

Identifiers

DOI

10.1038/NI1012

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1 August 2017

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