COX-2 and beyond: Approaches to prostaglandin inhibition in human disease (Q34282832)

1 August 2017

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title

COX-2 and beyond: Approaches to prostaglandin inhibition in human disease (English)

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1 August 2017

Garret A FitzGerald

1

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1 August 2017

1 November 2003

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Nature Reviews Drug Discovery

1 August 2017

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1 August 2017

2

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1 August 2017

11

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1 August 2017

879-890

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https://scigraph.springernature.com/pub.10.1038/nrd1225

1 August 2017

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Effect of ibuprofen on cardioprotective effect of aspirin

31 March 2020

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Cyclooxygenase 2 and the kidney

31 March 2020

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Frequency of analgesic use and risk of hypertension in younger women

31 March 2020

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The impact of nonsteroidal anti-inflammatory drugs on blood pressure, with an emphasis on newer agents

31 March 2020

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31 March 2020

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Deficiency of COX-1 causes natriuresis and enhanced sensitivity to ACE inhibition

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Short- and long-term COX-2 inhibition reverses endothelial dysfunction in patients with hypertension

31 March 2020

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Selective COX-2 inhibition improves endothelial function in coronary artery disease

31 March 2020

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Effects of low-dose aspirin on endothelial function in hypertensive patients

31 March 2020

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Selective cyclo-oxygenase-2 inhibition with parecoxib acutely impairs endothelium-dependent vasodilatation in patients with essential hypertension

31 March 2020

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Modulation of aspirin-insensitive eicosanoid biosynthesis by 6-methylprednisolone in unstable angina

31 March 2020

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31 March 2020

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Effects of MF-tricyclic, a selective cyclooxygenase-2 inhibitor, on atherosclerosis progression and susceptibility to cytomegalovirus replication in apolipoprotein-E knockout mice

31 March 2020

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Acceleration of atherogenesis by COX-1-dependent prostanoid formation in low density lipoprotein receptor knockout mice

31 March 2020

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No effect of cyclooxygenase inhibition on plaque size in atherosclerosis-prone mice

31 March 2020

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Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice

31 March 2020

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Prostaglandin E2 suppresses chemokine production in human macrophages through the EP4 receptor

31 March 2020

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The thromboxane receptor antagonist S18886 but not aspirin inhibits atherogenesis in apo E-deficient mice: evidence that eicosanoids other than thromboxane contribute to atherosclerosis

31 March 2020

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Oxidative damage of cardiomyocytes is limited by extracellular regulated kinases 1/2-mediated induction of cyclooxygenase-2

31 March 2020

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Mechanism of cyclooxygenase-2 upregulation in late preconditioning

31 March 2020

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Cyclooxygenase-2 mediates the cardioprotective effects of the late phase of ischemic preconditioning in conscious rabbits

31 March 2020

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Roles of prostaglandin I(2) and thromboxane A(2) in cardiac ischemia-reperfusion injury: a study using mice lacking their respective receptors

31 March 2020

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Induction of cyclooxygenase-2 and activation of nuclear factor-kappaB in myocardium of patients with congestive heart failure.

31 March 2020

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COX-2–Dependent Cardiac Failure in Gh/tTG Transgenic Mice

31 March 2020

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The relationship between cyclooxygenase-2 expression and colorectal cancer.

31 March 2020

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The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis

31 March 2020

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Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)

31 March 2020

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31 March 2020

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Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial

31 March 2020

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Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration

31 March 2020

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Inferior collicular seizure generalization produces site-selective cortical induction of cyclooxygenase 2 (COX-2).

31 March 2020

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Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology.

31 March 2020

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31 March 2020

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31 March 2020

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NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo

31 March 2020

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In vitro detection of (S)-naproxen and ibuprofen binding to plaques in the Alzheimer's brain using the positron emission tomography molecular imaging probe 2-(1-[6-[(2-[(18)F]fluoroethyl)(methyl)amino]-2-naphthyl]ethylidene)malononitrile

31 March 2020

1 reference

COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression

31 March 2020

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Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase

31 March 2020

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Microsomal Prostaglandin E Synthase-1 Is a Major Terminal Synthase That Is Selectively Up-Regulated During Cyclooxygenase-2-Dependent Prostaglandin E2 Production in the Rat Adjuvant-Induced Arthritis Model

31 March 2020

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Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2.

31 March 2020

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Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis

31 March 2020

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Arachidonic acid and prostaglandin endoperoxide metabolism in isolated rabbit and coronary microvessels and isolated and cultivated coronary microvessel endothelial cells

31 March 2020

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Cyclooxygenase-2 in human and experimental ischemic proliferative retinopathy

31 March 2020

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Genetic and pharmacological analysis of prostanoid receptor function

31 March 2020

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Effects of nonsteroidal anti-inflammatory drug therapy on blood pressure and peripheral edema

31 March 2020

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The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase

31 March 2020

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Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD1225

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PubMed ID

14668809

Dimensions Publication ID

1 August 2017

0 references

1 reference

PubMed ID

14668809