Multidrug transport by ATP binding cassette transporters: a proposed two-cylinder engine mechanism (Q34290848)

1 August 2017

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title

Multidrug transport by ATP binding cassette transporters: a proposed two-cylinder engine mechanism (English)

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1 August 2017

van Veen HW

1

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PubMed ID

11421284

1 August 2017

Higgins CF

series ordinal

2

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PubMed ID

11421284

1 August 2017

Konings WN

series ordinal

3

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1 August 2017

1 April 2001

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1 August 2017

Research in Microbiology

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1 August 2017

152

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1 August 2017

3-4

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1 August 2017

365-374

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Biochemical, cellular, and pharmacological aspects of the multidrug transporter

1 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0923-2508%2801%2901208-6

7 January 2021

Co-operative, competitive and non-competitive interactions between modulators of P-glycoprotein

1 reference

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7 January 2021

Inventory and function of yeast ABC proteins: about sex, stress, pleiotropic drug and heavy metal resistance

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7 January 2021

Multidrug resistance in Lactococcus lactis: evidence for ATP-dependent drug extrusion from the inner leaflet of the cytoplasmic membrane.

1 reference

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7 January 2021

Energetics and mechanism of drug transport mediated by the lactococcal multidrug transporter LmrP.

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7 January 2021

Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp

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7 January 2021

Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

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7 January 2021

A single membrane-embedded negative charge is critical for recognizing positively charged drugs by the Escherichia coli multidrug resistance protein MdfA.

1 reference

https://api.crossref.org/works/10.1016%2FS0923-2508%2801%2901208-6

7 January 2021

Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export

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7 January 2021

DNA-containing liposomes as a model for the study of cell membrane permeation by anthracycline derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS0923-2508%2801%2901208-6

7 January 2021

Genetic analysis of the multidrug transporter

1 reference

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7 January 2021

Osmoregulated ABC-transport system of Lactococcus lactis senses water stress via changes in the physical state of the membrane

1 reference

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7 January 2021

ABC Transporters: From Microorganisms to Man

1 reference

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7 January 2021

Is the multidrug transporter a flippase?

1 reference

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7 January 2021

Structure of the multidrug resistance P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0923-2508%2801%2901208-6

7 January 2021

Structural, mechanistic and clinical aspects of MRP1.

1 reference

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7 January 2021

ABC-ATPases, adaptable energy generators fuelling transmembrane movement of a variety of molecules in organisms from bacteria to humans

1 reference

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7 January 2021

Anticancer drugs, ionophoric peptides, and steroids as substrates of the yeast multidrug transporter Pdr5p

1 reference

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7 January 2021

Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance

1 reference

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7 January 2021

Functional analysis of a tryptophan-less P-glycoprotein: a tool for tryptophan insertion and fluorescence spectroscopy

1 reference

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7 January 2021

Both lobes of the soluble receptor of the periplasmic histidine permease, an ABC transporter (traffic ATPase), interact with the membrane-bound complex. Effect of different ligands and consequences for the mechanism of action

1 reference

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7 January 2021

Determining the structure and mechanism of the human multidrug resistance P-glycoprotein using cysteine-scanning mutagenesis and thiol-modification techniques

1 reference

https://api.crossref.org/works/10.1016%2FS0923-2508%2801%2901208-6

7 January 2021

Communication between multiple drug binding sites on P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0923-2508%2801%2901208-6

7 January 2021

P-glycoprotein function involves conformational transitions detectable by differential immunoreactivity

1 reference

https://api.crossref.org/works/10.1016%2FS0923-2508%2801%2901208-6

7 January 2021

A membrane-embedded glutamate is required for ligand binding to the multidrug transporter EmrE

1 reference

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7 January 2021

Molecular interactions in ribose transport: the binding protein module symmetrically associates with the homodimeric membrane transporter

1 reference

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7 January 2021

Molecular properties of bacterial multidrug transporters

1 reference

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7 January 2021

Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state

1 reference

https://api.crossref.org/works/10.1016%2FS0923-2508%2801%2901208-6

7 January 2021

A general pattern for substrate recognition by P-glycoprotein.

1 reference

https://api.crossref.org/works/10.1016%2FS0923-2508%2801%2901208-6

7 January 2021

Substrate recognition by P-glycoprotein and the multidrug resistance-associated protein MRP1: a comparison.

1 reference

https://api.crossref.org/works/10.1016%2FS0923-2508%2801%2901208-6

7 January 2021

P-glycoprotein shows strong catalytic cooperativity between the two nucleotide sites.

1 reference

https://api.crossref.org/works/10.1016%2FS0923-2508%2801%2901208-6

7 January 2021

The catalytic cycle of P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0923-2508%2801%2901208-6

7 January 2021

Extraction of Hoechst 33342 from the cytoplasmic leaflet of the plasma membrane by P-glycoprotein.

1 reference

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7 January 2021

Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities

1 reference

https://api.crossref.org/works/10.1016%2FS0923-2508%2801%2901208-6

7 January 2021

Insights into the structure and substrate interactions of the P-glycoprotein multidrug transporter from spectroscopic studies

1 reference

https://api.crossref.org/works/10.1016%2FS0923-2508%2801%2901208-6

7 January 2021

Synthetic hydrophobic peptides are substrates for P-glycoprotein and stimulate drug transport

1 reference

https://api.crossref.org/works/10.1016%2FS0923-2508%2801%2901208-6

7 January 2021

Secondary and tertiary structure changes of reconstituted P-glycoprotein. A Fourier transform attenuated total reflection infrared spectroscopy analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0923-2508%2801%2901208-6

7 January 2021

Ligand-mediated tertiary structure changes of reconstituted P-glycoprotein. A tryptophan fluorescence quenching analysis

1 reference

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7 January 2021

Translocation pathway in the catalysis of active transport

1 reference

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7 January 2021

Comparative aspects of the function and mechanism of SUR1 and MDR1 proteins

1 reference

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7 January 2021

How does P-glycoprotein recognize its substrates?

1 reference

https://api.crossref.org/works/10.1016%2FS0923-2508%2801%2901208-6

7 January 2021

P-glycoprotein is stably inhibited by vanadate-induced trapping of nucleotide at a single catalytic site

1 reference

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7 January 2021

A bacterial antibiotic-resistance gene that complements the human multidrug-resistance P-glycoprotein gene

1 reference

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7 January 2021

The homodimeric ATP-binding cassette transporter LmrA mediates multidrug transport by an alternating two-site (two-cylinder engine) mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0923-2508%2801%2901208-6

7 January 2021

Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1.

1 reference

https://api.crossref.org/works/10.1016%2FS0923-2508%2801%2901208-6

7 January 2021

Secondary and tertiary structure changes of reconstituted LmrA induced by nucleotide binding or hydrolysis. A fourier transform attenuated total reflection infrared spectroscopy and tryptophan fluorescence quenching analysis.

1 reference

https://api.crossref.org/works/10.1016%2FS0923-2508%2801%2901208-6

7 January 2021

Dissection of drug-binding-induced conformational changes in P-glycoprotein.

1 reference

https://api.crossref.org/works/10.1016%2FS0923-2508%2801%2901208-6

7 January 2021

Structural basis of multidrug recognition by BmrR, a transcription activator of a multidrug transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0923-2508%2801%2901208-6

7 January 2021

A structure-based mechanism for drug binding by multidrug transporters

1 reference

https://api.crossref.org/works/10.1016%2FS0923-2508%2801%2901208-6

7 January 2021

10.1016/S0923-2508(01)01208-6

Identifiers

DOI

1 reference

1 August 2017

1 reference

PubMed ID

11421284