The loss of Cbl-phosphatidylinositol 3-kinase interaction perturbs RANKL-mediated signaling, inhibiting bone resorption and promoting osteoclast survival (Q34299184)

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English	The loss of Cbl-phosphatidylinositol 3-kinase interaction perturbs RANKL-mediated signaling, inhibiting bone resorption and promoting osteoclast survival	scientific article

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scholarly article

1 reference

Europe PubMed Central

1 August 2017

The loss of Cbl-phosphatidylinositol 3-kinase interaction perturbs RANKL-mediated signaling, inhibiting bone resorption and promoting osteoclast survival (English)

1 reference

Europe PubMed Central

1 August 2017

author name string

Naga Suresh Adapala

1

1 reference

Europe PubMed Central

1 August 2017

Mary F Barbe

2

1 reference

Europe PubMed Central

1 August 2017

Wallace Y Langdon

3

1 reference

Europe PubMed Central

1 August 2017

Mary C Nakamura

4

1 reference

Europe PubMed Central

1 August 2017

Alexander Y Tsygankov

5

1 reference

Europe PubMed Central

1 August 2017

Archana Sanjay

6

1 reference

Europe PubMed Central

1 August 2017

language of work or name

0 references

publication date

17 September 2010

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Europe PubMed Central

1 August 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

1 August 2017

285

1 reference

Europe PubMed Central

1 August 2017

47

1 reference

Europe PubMed Central

1 August 2017

36745-36758

1 reference

Europe PubMed Central

1 August 2017

c-Cbl promotes T cell receptor-induced thymocyte apoptosis by activating the phosphatidylinositol 3-kinase/Akt pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

Negative feedback control of osteoclast formation through ubiquitin-mediated down-regulation of NFATc1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

c-Cbl and Cbl-b act redundantly to protect osteoclasts from apoptosis and to displace HDAC6 from beta-tubulin, stabilizing microtubules and podosomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

Loss of Cbl-b increases osteoclast bone-resorbing activity and induces osteopenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

The p85alpha subunit of class IA phosphatidylinositol 3-kinase regulates the expression of multiple genes involved in osteoclast maturation and migration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2(-/-) mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

Genetic ablation of the c-Cbl ubiquitin ligase domain results in increased energy expenditure and improved insulin action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

Involvement of the Src-cortactin pathway in podosome formation and turnover during polarization of cultured osteoclasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

The molecular understanding of osteoclast differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

Identification and functional characterization of an Src homology domain 3 domain-binding site on Cbl

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

The Cbl family proteins: ring leaders in regulation of cell signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

The molecular dynamics of osteoclast adhesions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

The role(s) of Src kinase and Cbl proteins in the regulation of osteoclast differentiation and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

Role of ITAM-containing adapter proteins and their receptors in the immune system and bone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

Dynamin forms a Src kinase-sensitive complex with Cbl and regulates podosomes and osteoclast activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

RANKL-induced DC-STAMP is essential for osteoclastogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

Cbl-b interacts with ubiquitinated proteins; differential functions of the UBA domains of c-Cbl and Cbl-b

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

Src kinase activity is essential for osteoclast function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

Osteoclast differentiation and activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

The Cbl family: ubiquitin ligases regulating signaling by tyrosine kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

Bone homeostasis in growth hormone receptor-null mice is restored by IGF-I but independent of Stat5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

Bone resorption by osteoclasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

Gelsolin deficiency blocks podosome assembly and produces increased bone mass and strength

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

Cbl-b regulates the CD28 dependence of T-cell activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

Cellular survival: a play in three Akts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

Tyrosine phosphorylation of C-Cbl facilitates adhesion and spreading while suppressing anchorage-independent growth of V-Abl-transformed NIH3T3 fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

Altered thymic positive selection and intracellular signals in Cbl-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

c-Cbl is tyrosine-phosphorylated by interleukin-4 and enhances mitogenic and survival signals of interleukin-4 receptor by linking with the phosphatidylinositol 3'-kinase pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

Osteopetrosis in mice lacking haematopoietic transcription factor PU.1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

Osteopontin stimulates gelsolin-associated phosphoinositide levels and phosphatidylinositol triphosphate-hydroxyl kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

The NF-kappa B and I kappa B proteins: new discoveries and insights

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

The two major sites of cbl tyrosine phosphorylation in abl-transformed cells select the crkL SH2 domain

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee

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6 July 2018

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978603

6 July 2018

Phosphatidylinositol 3-kinase coordinately activates the MEK/ERK and AKT/NFkappaB pathways to maintain osteoclast survival.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.124628

21 January 2018

Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia

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https://api.crossref.org/works/10.1074%2FJBC.M110.124628

21 January 2018

PKB rescues calcineurin/NFAT-induced arrest of Rag expression and pre-T cell differentiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.124628

21 January 2018

Active protein kinase B regulates TCR responsiveness by modulating cytoplasmic-nuclear localization of NFAT and NF-kappa B proteins

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https://api.crossref.org/works/10.1074%2FJBC.M110.124628

21 January 2018

Inhibition of PI3K and calcineurin suppresses chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)-dependent responses of Th2 lymphocytes to prostaglandin D(2).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.124628

21 January 2018

Wortmannin, a specific inhibitor of phosphatidylinositol-3 kinase, blocks osteoclastic bone resorption.

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https://api.crossref.org/works/10.1074%2FJBC.M110.124628

21 January 2018

Fosl1 is a transcriptional target of c-Fos during osteoclast differentiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.124628

21 January 2018

c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling

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https://api.crossref.org/works/10.1074%2FJBC.M110.124628

21 January 2018

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

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https://api.crossref.org/works/10.1074%2FJBC.M110.124628

21 January 2018

Deletion of the gene encoding c-Cbl alters the ability of osteoclasts to migrate, delaying resorption and ossification of cartilage during the development of long bones

1 reference

https://pubmed.ncbi.nlm.nih.gov/20851882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20851882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidylinositol 3-kinase association with the osteoclast cytoskeleton, and its involvement in osteoclast attachment and spreading

1 reference

https://pubmed.ncbi.nlm.nih.gov/20851882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunocytochemical distribution of extracellular matrix receptors in human osteoclasts: A β3 integrin is colocalized with vinculin and talin in the podosomes of osteoclastoma giant cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20851882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The tyrosine phosphatase SHP-1 is a negative regulator of osteoclastogenesis and osteoclast resorbing activity: increased resorption and osteopenia in me(v)/me(v) mutant mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20851882

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M110.124628

1 reference

Europe PubMed Central

1 August 2017

1 reference

Europe PubMed Central

1 August 2017

1 reference

Europe PubMed Central

1 August 2017

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