Structural basis for HNF-4alpha activation by ligand and coactivator binding (Q34300855)

1 August 2017

title

Structural basis for HNF-4alpha activation by ligand and coactivator binding (English)

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1 August 2017

Karen Duda

1

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1 August 2017

Young-In Chi

series ordinal

2

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1 August 2017

Steven E Shoelson

series ordinal

3

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1 August 2017

language of work or name

English

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publication date

24 February 2004

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Journal of Biological Chemistry

1 August 2017

published in

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1 August 2017

volume

279

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1 August 2017

issue

22

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1 August 2017

page(s)

23311-23316

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Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand

1 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

Activation of the phosphoenolpyruvate carboxykinase gene retinoic acid response element is dependent on a retinoic acid receptor/coregulator complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

Transactivation of the human apolipoprotein CII promoter by orphan and ligand-dependent nuclear receptors. The regulatory element CIIC is a thyroid hormone response element.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

Transcriptional regulation of the apolipoprotein A-IV gene involves synergism between a proximal orphan receptor response element and a distant enhancer located in the upstream promoter region of the apolipoprotein C-III gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

Nuclear receptor-binding sites of coactivators glucocorticoid receptor interacting protein 1 (GRIP1) and steroid receptor coactivator 1 (SRC-1): multiple motifs with different binding specificities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4 alpha gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an ashkenazi jewish population.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

Structural studies on nuclear receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

Improved methods for building protein models in electron density maps and the location of errors in these models

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

Detection, delineation, measurement and display of cavities in macromolecular structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

A signature motif in transcriptional co-activators mediates binding to nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

Structure and specificity of nuclear receptor-coactivator interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

Crystal structure of the ligand binding domain of the human nuclear receptor PPARgamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

X-ray structure of the hRORalpha LBD at 1.63 A: structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

The three-dimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain: RU-486 induces a transconformation that leads to active antagonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

Molecular basis of agonism and antagonism in the oestrogen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400864200

21 January 2018

Identifiers

DOI

10.1074/JBC.M400864200

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1 August 2017

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