Activated MEK suppresses activation of PKR and enables efficient replication and in vivo oncolysis by Deltagamma(1)34.5 mutants of herpes simplex virus 1 (Q34302130)

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English	Activated MEK suppresses activation of PKR and enables efficient replication and in vivo oncolysis by Deltagamma(1)34.5 mutants of herpes simplex virus 1	scientific article

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15 January 2020

Activated MEK suppresses activation of PKR and enables efficient replication and in vivo oncolysis by Deltagamma(1)34.5 mutants of herpes simplex virus 1 (English)

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15 January 2020

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15 January 2020

Bernard Roizman

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Bernard Roizman

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15 January 2020

Ralph Weichselbaum

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Ralph R Weichselbaum

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15 January 2020

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Kerrington D Smith

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15 January 2020

James J Mezhir

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15 January 2020

Kai Bickenbach

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15 January 2020

Jula Veerapong

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15 January 2020

Mitchell C Posner

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1 February 2006

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15 January 2020

Journal of Virology

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15 January 2020

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15 January 2020

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15 January 2020

1110-1120

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15 January 2020

Targeting the mitogen-activated protein kinase cascade to treat cancer

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Targets and mechanisms for the regulation of translation in malignant transformation

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Herpes simplex virus 1 gene products occlude the interferon signaling pathway at multiple sites

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Defects in translational regulation mediated by the alpha subunit of eukaryotic initiation factor 2 inhibit antiviral activity and facilitate the malignant transformation of human fibroblasts

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Regulation of herpes simplex virus gamma(1)34.5 expression and oncolysis of diffuse liver metastases by Myb34.5.

1 reference

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Signal integration via PKR.

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Apoptosis suppression by Raf-1 and MEK1 requires MEK- and phosphatidylinositol 3-kinase-dependent signals

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Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial

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Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma

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The p42/p44 MAP kinase pathway prevents apoptosis induced by anchorage and serum removal

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6 July 2018

Rsk1 mediates a MEK-MAP kinase cell survival signal

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Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors

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6 July 2018

The herpes simplex virus US11 protein effectively compensates for the gamma1(34.5) gene if present before activation of protein kinase R by precluding its phosphorylation and that of the alpha subunit of eukaryotic translation initiation factor 2.

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12 December 2020

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10.1128/JVI.80.3.1110-1120.2006

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15 January 2020

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