ARF differentially modulates apoptosis induced by E2F1 and Myc. (Q34302211)

1 August 2017

title

ARF differentially modulates apoptosis induced by E2F1 and Myc. (English)

1 reference

1 August 2017

1 reference

Jamie L Russell

1

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1 August 2017

John T Powers

2

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1 August 2017

Robert J Rounbehler

3

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1 August 2017

Pamela M Rogers

4

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1 August 2017

Claudio J Conti

5

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1 August 2017

David G Johnson

6

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1 August 2017

language of work or name

English

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publication date

1 March 2002

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Molecular and Cellular Biology

1 August 2017

published in

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1 August 2017

volume

22

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1 August 2017

issue

5

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1 August 2017

page(s)

1360-1368

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1 August 2017

cites work

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Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation

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p19ARF targets certain E2F species for degradation.

6 July 2018

1 reference

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6 July 2018

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6 July 2018

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6 July 2018

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E2F4 and E2F1 have similar proliferative properties but different apoptotic and oncogenic properties in vivo

6 July 2018

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Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion

6 July 2018

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DNA damage-induced activation of p53 by the checkpoint kinase Chk2

6 July 2018

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The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

6 July 2018

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Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53

6 July 2018

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Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor

6 July 2018

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Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

6 July 2018

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Nucleolar Arf sequesters Mdm2 and activates p53

6 July 2018

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INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

6 July 2018

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6 July 2018

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E2F1 has both oncogenic and tumor-suppressive properties in a transgenic model

6 July 2018

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P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

6 July 2018

1 reference

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Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

6 July 2018

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A role for ATR in the DNA damage-induced phosphorylation of p53

6 July 2018

1 reference

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Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors

6 July 2018

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The complexity of p53 modulation: emerging patterns from divergent signals

6 July 2018

1 reference

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DNA damage activates p53 through a phosphorylation-acetylation cascade

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

p14ARF links the tumour suppressors RB and p53.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

Enhanced phosphorylation of p53 by ATM in response to DNA damage

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

E1A signaling to p53 involves the p19(ARF) tumor suppressor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

Adenovirus-mediated overexpression of the transcription factor E2F-1 induces apoptosis in human breast and ovarian carcinoma cell lines and does not require p53.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

Induction of DNA synthesis and apoptosis are separable functions of E2F-1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

Distinct roles for E2F proteins in cell growth control and apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

mdm2 expression is induced by wild type p53 activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

The p53-mdm-2 autoregulatory feedback loop

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

p53 and E2F-1 cooperate to mediate apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

A cell cycle regulator potentially involved in genesis of many tumor types

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

Sequences 5' of the bovine keratin 5 gene direct tissue- and cell-type-specific expression of a lacZ gene in the adult and during development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

Regulation of the specific DNA binding function of p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

Myc lacks E2F1's ability to suppress skin carcinogenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

Human ARF binds E2F1 and inhibits its transcriptional activity.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

A common E2F-1 and p73 pathway mediates cell death induced by TCR activation.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

Tumor spectrum in ARF-deficient mice.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

Overexpression of E2F-1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

Role of the INK4a locus in tumor suppression and cell mortality.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

p19ARF links the tumour suppressor p53 to Ras

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134697

Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development

28 October 2018

1 reference

12 December 2020

p16INK4A and p19ARF act in overlapping pathways in cellular immortalization

1 reference

12 December 2020

E2F1 mediates ectopic proliferation and stage-specific p53-dependent apoptosis but not aberrant differentiation in the ocular lens of Rb deficient fetuses

1 reference

12 December 2020

Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos

1 reference

12 December 2020

Signaling to p53: breaking the MDM2-p53 circuit

1 reference

12 December 2020

Phosphorylation of p53 serine 15 increases interaction with CBP

1 reference

12 December 2020

Phosphorylation of serine 392 stabilizes the tetramer formation of tumor suppressor protein p53

1 reference

12 December 2020

10.1128/MCB.22.5.1360-1368.2002

Identifiers

DOI

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1 August 2017

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1 August 2017

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