Mitochondrial quality control mediated by PINK1 and Parkin: links to parkinsonism. (Q34309906)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23125018%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

title

Mitochondrial quality control mediated by PINK1 and Parkin: links to parkinsonism (English)

1 reference

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17 February 2020

0 references

1 reference

2

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17 February 2020

3

Richard Youle

1 reference

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17 February 2020

author name string

Derek Narendra

series ordinal

1

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17 February 2020

publication date

1 November 2012

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Cold Spring Harbor Perspectives in Biology

17 February 2020

published in

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17 February 2020

volume

4

1 reference

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17 February 2020

issue

11

1 reference

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Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations.

17 February 2020

cites work

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6 July 2018

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Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment

6 July 2018

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Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin

6 July 2018

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PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility

6 July 2018

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6 July 2018

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Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane

6 July 2018

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The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking

6 July 2018

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Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts

6 July 2018

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PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease

6 July 2018

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Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's disease

6 July 2018

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Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy

6 July 2018

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p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding

6 July 2018

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Making heads or tails of phospholipids in mitochondria

6 July 2018

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Selective autophagy mediated by autophagic adapter proteins

6 July 2018

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Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

6 July 2018

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The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila

6 July 2018

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PINK1 cleavage at position A103 by the mitochondrial protease PARL.

6 July 2018

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The AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnover

6 July 2018

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Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

6 July 2018

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6 July 2018

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Genetic Analysis of Pathways to Parkinson Disease

6 July 2018

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DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

6 July 2018

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p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

6 July 2018

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Parkin Mono-ubiquitinates Bcl-2 and Regulates Autophagy

6 July 2018

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Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

6 July 2018

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6 July 2018

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6 July 2018

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p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria

6 July 2018

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Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells

6 July 2018

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6 July 2018

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Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

6 July 2018

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PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

6 July 2018

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Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations

6 July 2018

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The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway

6 July 2018

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Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin

6 July 2018

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PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

6 July 2018

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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

6 July 2018

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PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

6 July 2018

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Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling

6 July 2018

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6 July 2018

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Clueless, a conserved Drosophila gene required for mitochondrial subcellular localization, interacts genetically with parkin

6 July 2018

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6 July 2018

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6 July 2018

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Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation

6 July 2018

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Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking

6 July 2018

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6 July 2018

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Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase

6 July 2018

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Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin

6 July 2018

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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

6 July 2018

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PINK1 controls mitochondrial localization of Parkin through direct phosphorylation

6 July 2018

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The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila

6 July 2018

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Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

6 July 2018

1 reference

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The kinase domain of mitochondrial PINK1 faces the cytoplasm

6 July 2018

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A mitochondrial protein compendium elucidates complex I disease biology

6 July 2018

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Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery

6 July 2018

1 reference

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The PINK1/Parkin pathway regulates mitochondrial morphology

6 July 2018

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Mitochondria in the aetiology and pathogenesis of Parkinson's disease

6 July 2018

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Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin

6 July 2018

1 reference

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The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.

6 July 2018

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Familial parkinsonism and ophthalmoplegia from a mutation in the mitochondrial DNA helicase twinkle

6 July 2018

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PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1

6 July 2018

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Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

6 July 2018

1 reference

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Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

6 July 2018

1 reference

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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

6 July 2018

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High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

6 July 2018

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Lewy body Parkinson's disease in a large pedigree with 77 Parkin mutation carriers

6 July 2018

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Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease

6 July 2018

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Hereditary early-onset Parkinson's disease caused by mutations in PINK1

6 July 2018

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Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

6 July 2018

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Mitochondrial membrane remodelling regulated by a conserved rhomboid protease

6 July 2018

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Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

6 July 2018

1 reference

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

6 July 2018

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Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p

6 July 2018

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Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae

6 July 2018

1 reference

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Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses

6 July 2018

1 reference

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

6 July 2018

1 reference

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Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase.

6 July 2018

1 reference

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Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

6 July 2018

1 reference

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Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy.

6 July 2018

1 reference

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Impaired dopamine release and synaptic plasticity in the striatum of parkin-/- mice.

28 October 2018

1 reference

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Miro1 is a calcium sensor for glutamate receptor-dependent localization of mitochondria at synapses.

28 October 2018

1 reference

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Parkin as a tumor suppressor gene for hepatocellular carcinoma

28 October 2018

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Nature of mitochondrial DNA deletions in substantia nigra neurons

28 October 2018

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Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536340

The GTPase dMiro is required for axonal transport of mitochondria to Drosophila synapses.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536340

Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536340

Axonal transport of mitochondria to synapses depends on milton, a novel Drosophila protein

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536340

10.1101/CSHPERSPECT.A011338

28 October 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23125018%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23125018%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

PubMed publication ID

23125018

1 reference