Molecular model of anticonvulsant drug binding to the voltage-gated sodium channel inner pore (Q34310101)

1 August 2017

title

Molecular model of anticonvulsant drug binding to the voltage-gated sodium channel inner pore (English)

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1 August 2017

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Gregory M Lipkind

1

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1 August 2017

Harry A Fozzard

series ordinal

2

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1 August 2017

publication date

19 July 2010

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1 August 2017

published in

Molecular Pharmacology

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1 August 2017

volume

78

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1 August 2017

issue

4

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1 August 2017

page(s)

631-638

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Using lidocaine and benzocaine to link sodium channel molecular conformations to state-dependent antiarrhythmic drug affinity

1 August 2017

cites work

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Blockers of voltage-gated sodium channels for the treatment of central nervous system diseases

6 July 2018

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Charge at the lidocaine binding site residue Phe-1759 affects permeation in human cardiac voltage-gated sodium channels

6 July 2018

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A pharmacophore derived phenytoin analogue with increased affinity for slow inactivated sodium channels exhibits a desired anticonvulsant profile

6 July 2018

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The neurobiology of antiepileptic drugs

6 July 2018

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Crystal structure and mechanism of a calcium-gated potassium channel

6 July 2018

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Electrophysiological and pharmacological properties of the human brain type IIA Na+ channel expressed in a stable mammalian cell line

6 July 2018

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Voltage-gated sodium channels as therapeutic targets

6 July 2018

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The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

6 July 2018

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A common local anesthetic receptor for benzocaine and etidocaine in voltage-gated mu1 Na+ channels

6 July 2018

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Effects of log P and phenyl ring conformation on the binding of 5-phenylhydantoins to the voltage-dependent sodium channel

6 July 2018

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State-dependent inhibition of Na+ currents by the neuroprotective agent 619C89 in rat hippocampal neurons and in a mammalian cell line expressing rat brain type IIA Na+ channels

6 July 2018

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Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels

6 July 2018

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Amino-aromatic interactions in proteins

6 July 2018

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Electrostatic contributions of aromatic residues in the local anesthetic receptor of voltage-gated sodium channels

6 July 2018

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Molecular modeling of local anesthetic drug binding by voltage-gated sodium channels

28 October 2018

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Differential interactions of lamotrigine and related drugs with transmembrane segment IVS6 of voltage-gated sodium channels

28 October 2018

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Role of amino acid residues in transmembrane segments IS6 and IIS6 of the Na+ channel alpha subunit in voltage-dependent gating and drug block.

28 October 2018

1 reference

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Molecular determinants of voltage-dependent gating and binding of pore-blocking drugs in transmembrane segment IIIS6 of the Na(+) channel alpha subunit.

28 October 2018

1 reference

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Physicochemical properties and X-ray structural studies of the trigonal polymorph of carbamazepine

28 October 2018

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Point mutations at N434 in D1-S6 of mu1 Na(+) channels modulate binding affinity and stereoselectivity of local anesthetic enantiomers.

28 October 2018

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Sodium channels as molecular targets for antiepileptic drugs

28 October 2018

1 reference

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Molecular determinants of state-dependent block of Na+ channels by local anesthetics

28 October 2018

1 reference

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Slow binding of phenytoin to inactivated sodium channels in rat hippocampal neurons.

28 October 2018

1 reference

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Comparative molecular field analysis of hydantoin binding to the neuronal voltage-dependent sodium channel

28 October 2018

1 reference

12 December 2020

KcsA crystal structure as framework for a molecular model of the Na(+) channel pore

1 reference

12 December 2020

Aromatic rings act as hydrogen bond acceptors

1 reference

12 December 2020

Antiepileptic drug mechanisms of action

1 reference

12 December 2020

Synthesis, anticonvulsant activity, and structure-activity relationships of sodium channel blocking 3-aminopyrroles

1 reference

12 December 2020

A common anticonvulsant binding site for phenytoin, carbamazepine, and lamotrigine in neuronal Na+ channels

1 reference

12 December 2020

Identifiers

DOI

10.1124/MOL.110.064683

1 reference

1 August 2017

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1 August 2017

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