The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells (Q34310345)

1 August 2017

The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells (English)

1 reference

1 August 2017

Sian M Henson

2

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Arne N Akbar

object named as

Arne N Akbar

series ordinal

4

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David Escors

object named as

David Escors

series ordinal

3

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author name string

Alessio Lanna

series ordinal

1

1 reference

PubMed ID

25151490

1 August 2017

language of work or name

English

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publication date

24 August 2014

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1 August 2017

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1 August 2017

15

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1 August 2017

10

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1 August 2017

965-972

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https://scigraph.springernature.com/pub.10.1038/ni.2981

1 August 2017

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cites work

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p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice

6 July 2018

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p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes

6 July 2018

1 reference

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Mechanism and consequence of the autoactivation of p38α mitogen-activated protein kinase promoted by TAB1

6 July 2018

1 reference

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Posttranscriptional control of T cell effector function by aerobic glycolysis

6 July 2018

1 reference

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Knockdown of AMP-activated protein kinase alpha 1 and alpha 2 catalytic subunits.

6 July 2018

1 reference

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AMPKα1: a glucose sensor that controls CD8 T-cell memory

6 July 2018

1 reference

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p38 (MAPK) stress signalling in replicative senescence in fibroblasts from progeroid and genomic instability syndromes

6 July 2018

1 reference

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AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function

6 July 2018

1 reference

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Metabolism, migration and memory in cytotoxic T cells

6 July 2018

1 reference

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CD28(-) T cells: their role in the age-associated decline of immune function

6 July 2018

1 reference

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Genetic disruption of p38alpha Tyr323 phosphorylation prevents T-cell receptor-mediated p38alpha activation and impairs interferon-gamma production

6 July 2018

1 reference

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Living on a break: cellular senescence as a DNA-damage response

6 July 2018

1 reference

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Targeting dendritic cell signaling to regulate the response to immunization

6 July 2018

1 reference

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The relationship between p38 mitogen-activated protein kinase and AMP-activated protein kinase during myocardial ischemia

6 July 2018

1 reference

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Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family.

6 July 2018

1 reference

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Telomerase in T lymphocytes: use it and lose it?

6 July 2018

1 reference

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In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMP-activated protein kinase

6 July 2018

1 reference

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Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-kappaB transcription factors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190666

Oxygen free radicals in cell senescence: are they signal transducers?

6 July 2018

1 reference

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The many paths to p38 mitogen-activated protein kinase activation in the immune system

6 July 2018

1 reference

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The p38 mitogen-activated protein kinase signaling cascade in CD4 T cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190666

CD28 extinction in human T cells: altered functions and the program of T-cell senescence

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190666

Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190666

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190666

Telomere erosion in memory T cells induced by telomerase inhibition at the site of antigenic challenge in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190666

T cell receptor signaling: beyond complex complexes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190666

CD28 loss in senescent CD4+ T cells: reversal by interleukin-12 stimulation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190666

TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190666

Telomeres in T and B cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190666

MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190666

Mammalian MAP kinase signalling cascades

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190666

Inhibition of p38 MAP kinase as a therapeutic strategy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190666

TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190666

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190666

Will telomere erosion lead to a loss of T-cell memory?

6 July 2018

1 reference

Cytomegalovirus-specific CD4+ T cells in healthy carriers are continuously driven to replicative exhaustion.

21 January 2018

1 reference

KLRG1 signaling induces defective Akt (ser473) phosphorylation and proliferative dysfunction of highly differentiated CD8+ T cells.

21 January 2018

1 reference

Cytomegalovirus infection induces the accumulation of short-lived, multifunctional CD4+CD45RA+CD27+ T cells: the potential involvement of interleukin-7 in this process.

21 January 2018

1 reference

Reversible senescence in human CD4+CD45RA+CD27- memory T cells.

21 January 2018

1 reference

MAPK p38: alternative and nonstressful in T cells

21 January 2018

1 reference

The loss of telomerase activity in highly differentiated CD8+CD28-CD27- T cells is associated with decreased Akt (Ser473) phosphorylation.

21 January 2018

1 reference

AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heart

21 January 2018

1 reference

Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?

21 January 2018

1 reference

IFN-α inhibits telomerase in human CD8⁺ T cells by both hTERT downregulation and induction of p38 MAPK signaling

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190666

Choreography of MAGUKs during T cell activation

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25151490

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

p38 mitogen-activated protein kinase mediates adenosine-induced alterations in myocardial glucose utilization via 5'-AMP-activated protein kinase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25151490

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NI.2981

1 reference

PubMed ID

25151490

Dimensions Publication ID

1 August 2017

0 references

1 reference

1 August 2017

1 reference

PubMed ID

25151490