Living on a break: cellular senescence as a DNA-damage response (Q37198572)

18 August 2017

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title

Living on a break: cellular senescence as a DNA-damage response (English)

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Fabrizio d'Adda di Fagagna

18 August 2017

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series ordinal

1

object named as

Fabrizio d'Adda di Fagagna

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PubMed ID

18574463

18 August 2017

language of work or name

English

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publication date

1 July 2008

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18 August 2017

Nature Reviews Cancer

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18 August 2017

8

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18 August 2017

512-522

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18 August 2017

7

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https://scigraph.springernature.com/pub.10.1038/nrc2440

18 August 2017

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cites work

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MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

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MDC1 is required for the intra-S-phase DNA damage checkpoint

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MDC1 is a mediator of the mammalian DNA damage checkpoint

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Checkpoint signalling: focusing on 53BP1.

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Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

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MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

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MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals

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Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1

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ATR and ATRIP: partners in checkpoint signaling

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Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway

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TopBP1 activates the ATR-ATRIP complex

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Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation

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Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

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Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

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Growth of persistent foci of DNA damage checkpoint factors is essential for amplification of G1 checkpoint signaling

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Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage

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DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

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Cellular senescence: when bad things happen to good cells

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Functional links between telomeres and proteins of the DNA-damage response

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The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response

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Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.

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Telomeres shorten during ageing of human fibroblasts

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DNA damage foci at dysfunctional telomeres

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A DNA damage checkpoint response in telomere-initiated senescence

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Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

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The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability

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Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening

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Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination

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DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion

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A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends

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Does a sentinel or a subset of short telomeres determine replicative senescence?

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The nature of telomere fusion and a definition of the critical telomere length in human cells

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The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence.

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Werner syndrome protein limits MYC-induced cellular senescence

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A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors

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Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland

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Non-transcriptional control of DNA replication by c-Myc

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Cell-cycle checkpoints and cancer

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Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress.

31 March 2020

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A p53-dependent checkpoint pathway prevents rereplication

31 March 2020

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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

31 March 2020

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Oncogene-induced replication stress preferentially targets common fragile sites in preneoplastic lesions. A genome-wide study

31 March 2020

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Heterochromatin and its relationship to cell senescence and cancer therapy

31 March 2020

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Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

31 March 2020

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Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression

31 March 2020

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Chromatin dynamics and the preservation of genetic information

31 March 2020

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Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway

31 March 2020

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Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks

31 March 2020

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

31 March 2020

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Senescence-associated beta-galactosidase is lysosomal beta-galactosidase

31 March 2020

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From cells to organisms: can we learn about aging from cells in culture?

31 March 2020

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Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

31 March 2020

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DNA repair is limiting for haematopoietic stem cells during ageing

31 March 2020

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31 March 2020

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Restoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiation

31 March 2020

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Reversal of human cellular senescence: roles of the p53 and p16 pathways

31 March 2020

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Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

31 March 2020

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p16INK4a induces an age-dependent decline in islet regenerative potential

31 March 2020

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Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

31 March 2020

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The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

31 March 2020

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Oncogene-induced senescence as an initial barrier in lymphoma development

31 March 2020

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Tumour biology: senescence in premalignant tumours

31 March 2020

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Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

31 March 2020

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Complex engagement of DNA damage response pathways in human cancer and in lung tumor progression

31 March 2020

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

31 March 2020

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Patterns of somatic mutation in human cancer genomes

31 March 2020

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Genome instability: a mechanistic view of its causes and consequences

31 March 2020

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Retinoblastoma pathway defects show differential ability to activate the constitutive DNA damage response in human tumorigenesis

31 March 2020

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Restoration of p53 function leads to tumour regression in vivo

31 March 2020

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

31 March 2020

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Chemokine signaling via the CXCR2 receptor reinforces senescence

31 March 2020

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Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network

31 March 2020

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Disappearance of the telomere dysfunction-induced stress response in fully senescent cells.

31 March 2020

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A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.

31 March 2020

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The Rad53 signal transduction pathway: Replication fork stabilization, DNA repair, and adaptation

31 March 2020

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Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence

31 March 2020

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Short telomeres limit tumor progression in vivo by inducing senescence

31 March 2020

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Delayed ageing through damage protection by the Arf/p53 pathway

31 March 2020

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Divorcing ARF and p53: an unsettled case

31 March 2020

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Oncogenic ras and p53 cooperate to induce cellular senescence

31 March 2020

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Aging and genome maintenance

31 March 2020

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ATR signaling can drive cells into senescence in the absence of DNA breaks

31 March 2020

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Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

31 March 2020

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DNA damage-dependent nuclear dynamics of the Mre11 complex

31 March 2020

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BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation.

31 March 2020

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Extension of life-span by introduction of telomerase into normal human cells

31 March 2020

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Developmental differences in the immortalization of lung fibroblasts by telomerase

31 March 2020

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Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions

31 March 2020

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Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

31 March 2020

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The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

31 March 2020

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Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

31 March 2020

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Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

31 March 2020

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Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response.

31 March 2020

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The POT1-TPP1 telomere complex is a telomerase processivity factor

31 March 2020

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Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres

31 March 2020

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A negative feedback signaling network underlies oncogene-induced senescence

31 March 2020

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

31 March 2020

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Senescence of human fibroblasts induced by oncogenic Raf.

31 March 2020

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Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

31 March 2020

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Transforming growth factor beta triggers two independent-senescence programs in cancer cells

31 March 2020

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Smurf2 up-regulation activates telomere-dependent senescence

31 March 2020

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PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

31 March 2020

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Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC2440

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18 August 2017

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PubMed ID

18574463