From symptomatic treatments to causative therapy? (Q34318030)

1 August 2017

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title

From symptomatic treatments to causative therapy? (English)

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1 August 2017

Whittaker PA

1

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1 August 2017

1 August 2001

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Current Opinion in Chemical Biology

1 August 2017

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1 August 2017

5

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1 August 2017

4

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1 August 2017

352-359

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Initial sequencing and analysis of the human genome

1 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

The Sequence of the Human Genome

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Current status and perspectives in clinical islet transplantation.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Pharmacologic therapy for type 2 diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Ongoing trials in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

From entropy to Duino

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Chronic obstructive pulmonary disease: emerging therapies

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Historical perspectives and natural history of bipolar disorder

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Osteoarthritis: no cure, but many options for symptom relief.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Effects of inhaled corticosteroids on the consequences of asthma

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Psychopharmacologic treatment strategies for depression, bipolar disorder, and schizophrenia

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Prevention of coronary artery disease

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Coronary artery disease: the role of lipids, hypertension and smoking

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Allergen immunotherapy: novel approaches in the management of allergic diseases and asthma

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

New trends in immunotherapy to prevent atopic diseases

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

The genetics of complex diseases

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

DNA microarrays for expression profiling

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

DNA microarrays: raising the profile

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

The alliance of genes and environment in asthma and allergy

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

ApoE-4 and age at onset of Alzheimer's disease: the NIMH genetics initiative.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Alpha-2 macroglobulin is genetically associated with Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Genetics of lipoprotein abnormalities associated with coronary artery disease susceptibility

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

No genetic association between the LRP receptor and sporadic or late-onset familial Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

A Genome Scan for Type 2 Diabetes Susceptibility Loci in a Genetically Isolated Population

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Identification of the gene loci that predispose to rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Osteoarthritis-susceptibility locus on chromosome 11q, detected by linkage.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Susceptibility locus for Alzheimer's disease on chromosome 10.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Linkage and associated studies of schizophrenia

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Searching high and low: a review of the genetics of bipolar disorder

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Evidence for a gene influencing blood pressure on chromosome 17. Genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the framingham heart study

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Mapping and identification of autoimmunity genes

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Calpain 10: the first positional cloning of a gene for type 2 diabetes?

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

1 reference

7 January 2021

Molecular and genetic bases for maturity onset diabetes of youth

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

1 reference

7 January 2021

The genetics of essential hypertension

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

New gene tied to common form of Alzheimer's.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Therapeutic approaches to Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Mouse models of alpha-synucleinopathy and Lewy pathology.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Expression of mutant alpha-synuclein causes increased susceptibility to dopamine toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

PAN, the proteasome-activating nucleotidase from archaebacteria, is a protein-unfolding molecular chaperone

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Massive parallel gene expression profiling of RINm5F pancreatic islet beta-cells stimulated with interleukin-1beta

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissues

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Expression profiling of pancreatic beta-cells: glucose regulation of secretory and metabolic pathway genes

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Construction of a human cardiovascular cDNA microarray: portrait of the failing heart

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Overexpression of eotaxin and the CCR3 receptor in human atherosclerosis: using genomic technology to identify a potential novel pathway of vascular inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Large scale gene expression analysis of cholesterol-loaded macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Differential display identification of 40 genes with altered expression in activated human smooth muscle cells. Local expression in atherosclerotic lesions of smags, smooth muscle activation-specific genes

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Analysis of immune system gene expression in small rheumatoid arthritis biopsies using a combination of subtractive hybridization and high-density cDNA arrays

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Expression profile of transcripts in Alzheimer's disease tangle-bearing CA1 neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

beta-peptide immunization: a possible new treatment for Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Neuroscience. An antibiotic to treat Alzheimer's?

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

DNA immunization to prevent autoimmune diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Pathogenesis, prediction and trials for the prevention of insulin-dependent (type 1) diabetes mellitus1Abbreviations: s.c., subcutaneous; i.p., intraperitoneal; i.v., intravenous; IFA, incomplete Freund's adjuvant; DTP, diphtheria-tetanus-pertussis;

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Vaccine-induced antibodies inhibit CETP activity in vivo and reduce aortic lesions in a rabbit model of atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

A vaccine approach to healthy lipoprotein levels

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Tumour necrosis factor-alpha blockade: a new era for effective management of rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Update in rheumatology

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

A second susceptibility gene for developing rheumatoid arthritis in the human MHC is localized within a 70-kb interval telomeric of the TNF genes in the HLA class III region

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Impact of human genome sequencing for in silico target discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

In silico research in drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Protein profiling comes of age.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Uncovering functionally relevant signaling pathways using microarray-based expression profiling

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Transgenic gene knock-outs: functional genomics and therapeutic target selection

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Ribozymes as tools for therapeutic target validation in arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Elucidating cell signaling mechanisms using antisense technology

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Therapeutic target discovery using Caenorhabditis elegans.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Drug discovery in the next millennium

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Large-scale N-ethyl-N-nitrosourea mutagenesis of mice--from phenotypes to genes

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

New advances in pharmacogenomics

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Scope and consequences of peptic ulcer disease. How important is asymptomatic Helicobacter pylori infection?

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

In silico mapping of complex disease-related traits in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900214-3

7 January 2021

10.1016/S1367-5931(00)00214-3

Identifiers

DOI

1 reference

1 August 2017

1 reference

PubMed ID

11470596