Unfolded p53 in the pathogenesis of Alzheimer's disease: is HIPK2 the link? (Q34322386)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20876941%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference

31 July 2022

Unfolded p53 in the pathogenesis of Alzheimer's disease: is HIPK2 the link? (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20876941%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

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14 February 2020

Gabriella D'Orazi

5

1 reference

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14 February 2020

Marco Racchi

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1 reference

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14 February 2020

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Cristina Lanni

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14 February 2020

Stefano Govoni

3

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14 February 2020

Daniela Uberti

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14 February 2020

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1 September 2010

9 references

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20 December 2019

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14 February 2020

31 July 2022

9 references

25 April 2019

28 September 2019

28 November 2019

11 December 2019

18 December 2019

19 December 2019

20 December 2019

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14 February 2020

31 July 2022

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14 February 2020

issue

9

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cites work

p53, ROS and senescence in the control of aging

1 reference

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The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway

6 July 2018

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Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells.

6 July 2018

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Paradoxical suppression of cellular senescence by p53

6 July 2018

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Homeodomain interacting protein kinase 2: a target for Alzheimer's beta amyloid leading to misfolded p53 and inappropriate cell survival

6 July 2018

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Beta-amyloid: a disease target or a synaptic regulator affecting age-related neurotransmitter changes?

6 July 2018

1 reference

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HIPK2-a therapeutical target to be (re)activated for tumor suppression: role in p53 activation and HIF-1α inhibition.

6 July 2018

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Tumor suppression by p53: making cells senescent

6 July 2018

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Nox1 is involved in p53 deacetylation and suppression of its transcriptional activity and apoptosis.

6 July 2018

1 reference

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mTOR's role in ageing: protein synthesis or autophagy?

6 July 2018

1 reference

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Tumor suppressive functions of p53

6 July 2018

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HIPK2 modulates p53 activity towards pro-apoptotic transcription

6 July 2018

1 reference

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Zinc in the physiology and pathology of the CNS.

6 July 2018

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Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha

6 July 2018

1 reference

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Why do centenarians escape or postpone cancer? The role of IGF-1, inflammation and p53.

6 July 2018

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Amyloid beta-protein assembly as a therapeutic target of Alzheimer's disease

6 July 2018

1 reference

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Transcriptional regulation of hypoxia-inducible factor 1alpha by HIPK2 suggests a novel mechanism to restrain tumor growth

6 July 2018

1 reference

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Restoring wtp53 activity in HIPK2 depleted MCF7 cells by modulating metallothionein and zinc.

6 July 2018

1 reference

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A complex barcode underlies the heterogeneous response of p53 to stress

6 July 2018

1 reference

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Reversible dysfunction of wild-type p53 following homeodomain-interacting protein kinase-2 knockdown

6 July 2018

1 reference

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Transcriptional control of human p53-regulated genes

6 July 2018

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Versatile functions of p53 protein in multicellular organisms

6 July 2018

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ATR signaling can drive cells into senescence in the absence of DNA breaks

6 July 2018

1 reference

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Two faces of p53: aging and tumor suppression

6 July 2018

1 reference

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Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations

6 July 2018

1 reference

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Unfolded p53: a potential biomarker for Alzheimer's disease.

6 July 2018

1 reference

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Over-expression of amyloid precursor protein in HEK cells alters p53 conformational state and protects against doxorubicin

6 July 2018

1 reference

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p53 in health and disease

6 July 2018

1 reference

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DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage

6 July 2018

1 reference

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A beta oligomers - a decade of discovery

6 July 2018

1 reference

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Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis

6 July 2018

1 reference

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E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation.

6 July 2018

1 reference

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The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging

6 July 2018

1 reference

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Zinc-binding proteins (metallothionein and alpha-2 macroglobulin) and immunosenescence.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate.

6 July 2018

1 reference

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Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

CK2 interacting proteins: emerging paradigms for CK2 regulation?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Potentiality of DNA-dependent protein kinase to phosphorylate Ser46 of human p53.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Modulation of mammalian life span by the short isoform of p53.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Metallothioneins in human tumors and potential roles in carcinogenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Regulation of p53 responses by post-translational modifications

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

APP processing and synaptic function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics

6 July 2018

1 reference

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Deconstructing PML-induced premature senescence

6 July 2018

1 reference

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ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation

6 July 2018

1 reference

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Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

p53 mutant mice that display early ageing-associated phenotypes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

beta-amyloid deposits in transgenic mice expressing human beta-amyloid precursor protein have the same characteristics as those in Alzheimer's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Post-translational modifications and activation of p53 by genotoxic stresses

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

6 July 2018

Surfing the p53 network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Regulation of APP cleavage by alpha-, beta- and gamma-secretases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Inflamm-aging. An evolutionary perspective on immunosenescence

6 July 2018

1 reference

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Zinc and immunoresistance to infection in aging: new biological tools

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Induction, regulation, degradation, and biological significance of mammalian metallothioneins.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Redox signalling and transition metals in the control of the p53 pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

p53 and human cancer: the first ten thousand mutations.

6 July 2018

1 reference

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Metallothionein in radiation exposure: its induction and protective role

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Amyloid beta protein 42(43) in cerebrospinal fluid of patients with Alzheimer's disease.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Biochemistry of metallothionein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Structural organization of the human p53 gene. I. Molecular cloning of the human p53 gene

6 July 2018

1 reference

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Cancer. p53, guardian of the genome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Mutation of the casein kinase II phosphorylation site abolishes the anti-proliferative activity of p53.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Amyloid beta-peptide is produced by cultured cells during normal metabolism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

T antigen is bound to a host protein in SY40-transformed cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

P53 and aging: A fresh look at an old paradigm

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Unfolded p53 in blood as a predictive signature signature of the transition from mild cognitive impairment to Alzheimer's disease.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

P53-mediated G(1)/S checkpoint dysfunction in lymphocytes from Alzheimer's disease patients.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Pharmacogenetics and pharmagenomics, trends in normal and pathological aging studies: focus on p53.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Conformationally altered p53: a novel Alzheimer's disease marker?

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Acetylation of the p53 DNA-binding domain regulates apoptosis induction

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Identification of a mutant-like conformation of p53 in fibroblasts from sporadic Alzheimer's disease patients.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Metallothionein isoforms (I+II and III) and interleukin-6 in the hippocampus of old rats: may their concomitant increments lead to neurodegeneration?

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Amyloid beta-protein (Abeta)1-40 protects neurons from damage induced by Abeta1-42 in culture and in rat brain

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Selective impairment of p53-mediated cell death in fibroblasts from sporadic Alzheimer's disease patients.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Modulation of p53 protein conformation and DNA-binding activity by intracellular chelation of zinc.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Metallothionein Downregulation in Very Old Age: A Phenomenon Associated with Cellular Senescence?

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Delayed ageing through damage protection by the Arf/p53 pathway

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984604

Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases

28 October 2018

1 reference

12 December 2020

Plasma amyloid beta-peptide 1-42 and incipient Alzheimer's disease

1 reference

12 December 2020

Preservation of DNA integrity and neuronal degeneration

1 reference

12 December 2020

HIPK2-induced p53Ser46 phosphorylation activates the KILLER/DR5-mediated caspase-8 extrinsic apoptotic pathway

1 reference

12 December 2020

Metalloregulation of the tumor suppressor protein p53: zinc mediates the renaturation of p53 after exposure to metal chelators in vitro and in intact cells

1 reference

12 December 2020

Identifiers

DOI

10.18632/AGING.100205

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20876941%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20876941%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference