A complex barcode underlies the heterogeneous response of p53 to stress (Q37249372)

19 August 2017

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title

A complex barcode underlies the heterogeneous response of p53 to stress (English)

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19 August 2017

Fiona Murray-Zmijewski

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1

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19 August 2017

Elizabeth A Slee

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2

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19 August 2017

Xin Lu

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3

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19 August 2017

language of work or name

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1 September 2008

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Nature Reviews Molecular Cell Biology

19 August 2017

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19 August 2017

9

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19 August 2017

702-712

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19 August 2017

9

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https://scigraph.springernature.com/pub.10.1038/nrm2451

19 August 2017

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Surfing the p53 network

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Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses

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DRAM, a p53-induced modulator of autophagy, is critical for apoptosis

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Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma

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p53-mediated inhibition of angiogenesis through up-regulation of a collagen prolyl hydroxylase

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Exploiting the p53 pathway for cancer diagnosis and therapy

31 March 2020

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Different impact of p53 and p21 on the radiation response of mouse tissues

31 March 2020

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31 March 2020

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31 March 2020

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Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

31 March 2020

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Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?

31 March 2020

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In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin

31 March 2020

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31 March 2020

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RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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An essential function of the extreme C-terminus of MDM2 can be provided by MDMX

31 March 2020

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Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation

31 March 2020

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Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

31 March 2020

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Tumour suppression: disruption of HAUSP gene stabilizes p53

31 March 2020

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A dynamic role of HAUSP in the p53-Mdm2 pathway

31 March 2020

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Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

31 March 2020

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The ubiquitin ligase COP1 is a critical negative regulator of p53

31 March 2020

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CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation

31 March 2020

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How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?

31 March 2020

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Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity

31 March 2020

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The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation

31 March 2020

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Repression of p53 activity by Smyd2-mediated methylation

31 March 2020

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Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

31 March 2020

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Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation

31 March 2020

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p53 is regulated by the lysine demethylase LSD1

31 March 2020

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The importance of p53 location: nuclear or cytoplasmic zip code?

31 March 2020

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E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation.

31 March 2020

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Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation

31 March 2020

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A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

31 March 2020

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ASPP1 and ASPP2 are new transcriptional targets of E2F

31 March 2020

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Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage

31 March 2020

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Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

31 March 2020

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Localization of the E1B proteins of adenovirus 5 in transformed cells, as revealed by interaction with monoclonal antibodies.

31 March 2020

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Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis

31 March 2020

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Cytoplasmic retention of the p53 tumor suppressor gene product is observed in the hepatitis B virus X gene-transfected cells

31 March 2020

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Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.

31 March 2020

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Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation

31 March 2020

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C-terminal modifications regulate MDM2 dissociation and nuclear export of p53.

31 March 2020

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Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function.

31 March 2020

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Parc: a cytoplasmic anchor for p53.

31 March 2020

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Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1

31 March 2020

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Monoubiquitylation promotes mitochondrial p53 translocation

31 March 2020

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Regulation of autophagy by cytoplasmic p53

31 March 2020

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p53 has a direct apoptogenic role at the mitochondria

31 March 2020

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Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

31 March 2020

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Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

31 March 2020

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Mitochondrially targeted p53 has tumor suppressor activities in vivo

31 March 2020

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Hepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondria

31 March 2020

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p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells

31 March 2020

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Comparative binding of p53 to its promoter and DNA recognition elements.

31 March 2020

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Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

31 March 2020

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Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

31 March 2020

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DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage

31 March 2020

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p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

31 March 2020

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Acetylation of the p53 DNA-binding domain regulates apoptosis induction

31 March 2020

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Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis

31 March 2020

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Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate.

31 March 2020

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The tumor suppressor protein p53 is required for neurite outgrowth and axon regeneration

31 March 2020

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ASPP proteins specifically stimulate the apoptotic function of p53

31 March 2020

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iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.

31 March 2020

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p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

31 March 2020

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Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation

31 March 2020

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Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression

31 March 2020

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The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21(CIP1/Waf1).

31 March 2020

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Regulation of p53 activity in nuclear bodies by a specific PML isoform

31 March 2020

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The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

31 March 2020

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The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.

31 March 2020

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The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP

31 March 2020

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Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression

31 March 2020

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Transcriptional activation by p53 correlates with suppression of growth but not transformation.

31 March 2020

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Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant

31 March 2020

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A novel cofactor for p300 that regulates the p53 response

31 March 2020

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A new effector pathway links ATM kinase with the DNA damage response

31 March 2020

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A TPR motif cofactor contributes to p300 activity in the p53 response

31 March 2020

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Skp2 suppresses p53-dependent apoptosis by inhibiting p300.

31 March 2020

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hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes

31 March 2020

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CDK8 is a stimulus-specific positive coregulator of p53 target genes

31 March 2020

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Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.

31 March 2020

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The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM2451

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Dimensions Publication ID

19 August 2017

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