Regulation of p53 responses by post-translational modifications (Q35116637)

6 August 2017

1 reference

title

Regulation of p53 responses by post-translational modifications (English)

1 reference

6 August 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401182

28 December 2023

1

Yang Xu

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12719715

28 December 2023

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12719715

28 December 2023

publication date

1 April 2003

1 reference

full work available at URL

6 August 2017

http://www.nature.com/articles/4401182

1 reference

DOI

https://api.crossref.org/works/10.1038/SJ.CDD.4401182

http://www.nature.com/articles/4401182.pdf

28 December 2023

file format

Portable Document Format

1 reference

DOI

https://api.crossref.org/works/10.1038/SJ.CDD.4401182

Cell Death & Differentiation

28 December 2023

published in

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6 August 2017

10

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6 August 2017

400-403

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6 August 2017

4

1 reference

https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401182

6 August 2017

0 references

cites work

p53: puzzle and paradigm

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WAF1, a potential mediator of p53 tumor suppression

21 January 2018

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Radiation-induced cell cycle arrest compromised by p21 deficiency

21 January 2018

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Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

21 January 2018

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p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage

21 January 2018

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A transactivation-deficient mouse model provides insights into Trp53 regulation and function

21 January 2018

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Small peptides activate the latent sequence-specific DNA binding function of p53.

21 January 2018

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Reciprocal interference between the sequence-specific core and nonspecific C-terminal DNA binding domains of p53: implications for regulation

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.

21 January 2018

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Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

The p53-mdm-2 autoregulatory feedback loop

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Regulation of Mdm2-directed degradation by the C terminus of p53.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Mdm2 promotes the rapid degradation of p53

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Requirement of ATM in phosphorylation of the human p53 protein at serine 15 following DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Recruitment of p300/CBP in p53-dependent signal pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Regulation of p53 function and stability by phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Mutation of mouse p53 Ser23 and the response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

The alpha-helical FXXPhiPhi motif in p53: TAF interaction and discrimination by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: a new biomedical research tool.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Binding and modulation of p53 by p300/CBP coactivators

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

DNA damage activates p53 through a phosphorylation-acetylation cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Atmospheric carbon dioxide concentrations over the past 60 million years

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

p53 is phosphorylated in vitro and in vivo by an ultraviolet radiation-induced protein kinase characteristic of the c-Jun kinase, JNK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Stoichiometric phosphorylation of human p53 at Ser315 stimulates p53-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Phosphorylation of p53 at the casein kinase II site selectively regulates p53-dependent transcriptional repression but not transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Mutation of phosphoserine 389 affects p53 function in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

Phosphorylation of p53 serine 15 increases interaction with CBP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

7 January 2021

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

7 January 2021

Phosphorylation of murine p53, but not human p53, by MAP kinase in vitro and in cultured cells highlights species-dependent variation in post-translational modification

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

7 January 2021

Phosphorylation of serine 392 stabilizes the tetramer formation of tumor suppressor protein p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401182

7 January 2021

Identifiers

DOI

1 reference

Dimensions Publication ID

6 August 2017

1024962039

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Fatcat ID

release_l7owdegkcjewlpyzpzua5uvbkq

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Fatcat

https://api.fatcat.wiki/v0/release/l7owdegkcjewlpyzpzua5uvbkq

24 November 2022

mapped directly with Wikidata item

1 reference