On the effect of protein conformation diversity in discriminating among neutral and disease related single amino acid substitutions (Q34324950)

1 August 2017

title

On the effect of protein conformation diversity in discriminating among neutral and disease related single amino acid substitutions (English)

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1 August 2017

6

Gustavo Parisi

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1 August 2017

5

Rita Casadio

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1 August 2017

Ezequiel Juritz

1

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1 August 2017

Maria Silvina Fornasari

series ordinal

2

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1 August 2017

Pier Luigi Martelli

series ordinal

3

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1 August 2017

Piero Fariselli

series ordinal

4

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1 August 2017

language of work or name

English

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publication date

18 June 2012

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1 August 2017

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1 August 2017

volume

13 Suppl 4

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1 August 2017

page(s)

S5

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Correlating disease-related mutations to their effect on protein stability: a large-scale analysis of the human proteome

1 August 2017

cites work

1 reference

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.

6 July 2018

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Performance of protein stability predictors.

6 July 2018

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Increased monomerization of mutant HSPB1 leads to protein hyperactivity in Charcot-Marie-Tooth neuropathy

6 July 2018

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Triosephosphate isomerase deficiency: new insights into an enigmatic disease

6 July 2018

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Stability effects of mutations and protein evolvability

6 July 2018

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Using structural bioinformatics to investigate the impact of non synonymous SNPs and disease mutations: scope and limitations

6 July 2018

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The origin of allosteric functional modulation: multiple pre-existing pathways

6 July 2018

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Global distribution of conformational states derived from redundant models in the PDB points to non-uniqueness of the protein structure.

6 July 2018

1 reference

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6 July 2018

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Sending signals dynamically

6 July 2018

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6 July 2018

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Recognition dynamics up to microseconds revealed from an RDC-derived ubiquitin ensemble in solution

6 July 2018

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Restricted mobility of conserved residues in protein-protein interfaces in molecular simulations.

6 July 2018

1 reference

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The stability effects of protein mutations appear to be universally distributed

6 July 2018

1 reference

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The dynamic energy landscape of dihydrofolate reductase catalysis

6 July 2018

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Enzyme promiscuity: evolutionary and mechanistic aspects.

6 July 2018

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Relation between native ensembles and experimental structures of proteins

6 July 2018

1 reference

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6 July 2018

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Loss of protein structure stability as a major causative factor in monogenic disease.

6 July 2018

1 reference

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The FoldX web server: an online force field

6 July 2018

1 reference

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Molecular dynamics and protein function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3303731

Disease-associated mutations inactivate AMP-lysine hydrolase activity of Aprataxin

6 July 2018

1 reference

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Is allostery an intrinsic property of all dynamic proteins?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3303731

Carbonic anhydrase II deficiency syndrome (osteopetrosis with renal tubular acidosis and brain calcification): novel mutations in CA2 identified by direct sequencing expand the opportunity for genotype-phenotype correlation

6 July 2018

1 reference

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Antibody multispecificity mediated by conformational diversity

6 July 2018

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MAMMOTH (matching molecular models obtained from theory): an automated method for model comparison

6 July 2018

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Predicting changes in the stability of proteins and protein complexes: a study of more than 1000 mutations

6 July 2018

1 reference

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Multiple diverse ligands binding at a single protein site: a matter of pre-existing populations

6 July 2018

1 reference

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Protein folding: binding of conformationally fluctuating building blocks via population selection

6 July 2018

1 reference

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SNPs, protein structure, and disease.

6 July 2018

1 reference

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The structural basis of protein folding and its links with human disease

6 July 2018

1 reference

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Folding and binding cascades: dynamic landscapes and population shifts

6 July 2018

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6 July 2018

The Protein Data Bank

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ProTherm: Thermodynamic Database for Proteins and Mutants.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3303731

Knowledge-based potentials for proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3303731

Accurate prediction of the stability and activity effects of site-directed mutagenesis on a protein core

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3303731

Biochemistry. An ensemble view of allostery

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3303731

A structural bioinformatics approach to the analysis of nonsynonymous single nucleotide polymorphisms (nsSNPs) and their relation to disease.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3303731

PROCOGNATE: a cognate ligand domain mapping for enzymes

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3303731

Investigating the effects of mutations on protein aggregation in the cell.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3303731

Promotion of hyperphosphorylation by frontotemporal dementia tau mutations

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3303731

Predicting protein mutant energetics by self-consistent ensemble optimization.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3303731

Intrinsic secondary structure propensities of the amino acids, using statistical phi-psi matrices: comparison with experimental scales.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3303731

Relation between sequence and structure of HIV-1 protease inhibitor complexes: a model system for the analysis of protein flexibility

28 October 2018

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12 December 2020

Conformational diversity and protein evolution--a 60-year-old hypothesis revisited

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12 December 2020

Free energy calculations by computer simulation

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12 December 2020

Protein stability for single substitution mutants and the extent of local compactness in the denatured state

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12 December 2020

Polar and nonpolar atomic environments in the protein core: implications for folding and binding

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12 December 2020

10.1186/1471-2164-13-S4-S5

Identifiers

DOI

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1 August 2017

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1 August 2017

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