Pregnane X receptor and drug-induced liver injury. (Q34345049)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252616%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

review article

1 reference

title

Pregnane X receptor and drug-induced liver injury (English)

1 reference

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19 February 2020

2

1 reference

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19 February 2020

author name string

Yue-Ming Wang

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252616%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Christopher T Brewer

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252616%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Taosheng Chen

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252616%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

language of work or name

English

0 references

publication date

25 September 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252616%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Drug Metabolism & Toxicology

19 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252616%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

volume

10

1 reference

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19 February 2020

issue

11

1 reference

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19 February 2020

page(s)

1521-1532

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252616%20AND%20SRC:MED&resulttype=core&format=json

Drug-induced liver injury due to antimicrobials, central nervous system agents, and nonsteroidal anti-inflammatory drugs.

19 February 2020

cites work

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Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1

6 July 2018

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6 July 2018

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Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy

6 July 2018

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Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria

6 July 2018

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Drug-induced liver injury: the role of drug metabolism and transport

6 July 2018

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3D organotypic cultures of human HepaRG cells: a tool for in vitro toxicity studies

6 July 2018

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Cell-based systems to assess nuclear receptor activation and their use in drug development

6 July 2018

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PXR antagonists and implication in drug metabolism

6 July 2018

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Evaluation of pregnane X receptor (PXR)-mediated CYP3A4 drug-drug interactions in drug development

6 July 2018

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RBCK1, an E3 ubiquitin ligase, interacts with and ubiquinates the human pregnane X receptor

6 July 2018

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Sulforaphane is not an effective antagonist of the human pregnane X-receptor in vivo

6 July 2018

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Targeting the pregnane X receptor in liver injury

6 July 2018

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Sesamin: A Naturally Occurring Lignan Inhibits CYP3A4 by Antagonizing the Pregnane X Receptor Activation

6 July 2018

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Role of CAR and PXR in xenobiotic sensing and metabolism

6 July 2018

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Assessment of compound hepatotoxicity using human plateable cryopreserved hepatocytes in a 1536-well-plate format

6 July 2018

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Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene

6 July 2018

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6 July 2018

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6 July 2018

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In vivo and in vitro characterization of a first-in-class novel azole analog that targets pregnane X receptor activation

6 July 2018

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6 July 2018

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Mechanisms of drug-induced liver injury: from bedside to bench

6 July 2018

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Causality assessment methods in drug induced liver injury: strengths and weaknesses

6 July 2018

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Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells

6 July 2018

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Acetylation of pregnane X receptor protein determines selective function independent of ligand activation

6 July 2018

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Nuclear receptors in liver disease.

6 July 2018

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Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR

6 July 2018

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Dexamethasone transcriptionally increases the expression of the pregnane X receptor and synergistically enhances pyrethroid esfenvalerate in the induction of cytochrome P450 3A23.

6 July 2018

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Camptothecin attenuates cytochrome P450 3A4 induction by blocking the activation of human pregnane X receptor

6 July 2018

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6 July 2018

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CYP2C9*1B promoter polymorphisms, in linkage with CYP2C19*2, affect phenytoin autoinduction of clearance and maintenance dose

6 July 2018

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6 July 2018

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A systematic analysis of predicted phosphorylation sites within the human pregnane X receptor protein

6 July 2018

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Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity

6 July 2018

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Circulating microRNAs, potential biomarkers for drug-induced liver injury

6 July 2018

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PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics

6 July 2018

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Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States

6 July 2018

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A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4

6 July 2018

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Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells

6 July 2018

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A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.

6 July 2018

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Synthesis of novel ketoconazole derivatives as inhibitors of the human Pregnane X Receptor (PXR; NR1I2; also termed SXR, PAR).

6 July 2018

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Computational discovery of novel low micromolar human pregnane X receptor antagonists

6 July 2018

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Mechanisms of renal anionic drug transport

6 July 2018

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The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor

6 July 2018

1 reference

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A human immunodeficiency virus protease inhibitor is a novel functional inhibitor of human pregnane X receptor

6 July 2018

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Clinical hepatotoxicity. Regulation and treatment with inducers of transport and cofactors.

6 July 2018

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Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sites

6 July 2018

1 reference

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Crystal structure of the PXR–T1317 complex provides a scaffold to examine the potential for receptor antagonism

6 July 2018

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Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis

6 July 2018

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Antituberculosis drugs and hepatotoxicity

6 July 2018

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Drug-related hepatotoxicity

6 July 2018

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Methylation-associated silencing of the nuclear receptor 1I2 gene in advanced-type neuroblastomas, identified by bacterial artificial chromosome array-based methylated CpG island amplification

6 July 2018

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A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line

6 July 2018

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Idiosyncratic drug hepatotoxicity

6 July 2018

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Acetaminophen and the U.S. Acute Liver Failure Study Group: lowering the risks of hepatic failure

6 July 2018

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Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR).

6 July 2018

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Acetaminophen-induced hepatotoxicity

6 July 2018

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Acute Liver Failure in the United States

6 July 2018

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Yondelis (trabectedin, ET-743): the development of an anticancer agent of marine origin

6 July 2018

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Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor

6 July 2018

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Regulation of CYP3A4 expression in human hepatocytes by pharmaceuticals and natural products

6 July 2018

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A ligand-based approach to understanding selectivity of nuclear hormone receptors PXR, CAR, FXR, LXRalpha, and LXRbeta

6 July 2018

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The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4

6 July 2018

1 reference

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Incidence of drug-induced hepatic injuries: a French population-based study

6 July 2018

1 reference

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PXR, CAR and drug metabolism

6 July 2018

1 reference

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Epidemiology and individual susceptibility to adverse drug reactions affecting the liver

6 July 2018

1 reference

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The ontogeny of human drug-metabolizing enzymes: phase II conjugation enzymes and regulatory mechanisms

6 July 2018

1 reference

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Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity

6 July 2018

1 reference

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The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

6 July 2018

1 reference

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Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation.

6 July 2018

1 reference

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The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198438

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

6 July 2018

1 reference

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SXR, a novel steroid and xenobiotic-sensing nuclear receptor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198438

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

6 July 2018

1 reference

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P450 genes: structure, evolution, and regulation

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198438

Effect of methylxanthines on acetaminophen hepatotoxicity in various induction states

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198438

Effect of pregnenolone-16α-carbonitrile and dexamethasone on acetaminophen-induced hepatotoxicity in mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198438

Oral medications with significant hepatic metabolism at higher risk for hepatic adverse events

6 July 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.963555

Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.963555

Contribution of high basolateral bile salt efflux to the lack of hepatotoxicity in rat in response to drugs inducing cholestasis in human

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.963555

Nuclear receptors constitutive androstane receptor and pregnane X receptor activate a drug-responsive enhancer of the murine 5-aminolevulinic acid synthase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.963555

Enhanced acetaminophen toxicity by activation of the pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.963555

Induction of cytochrome P450 3A4 and P-glycoprotein by the isoxazolyl-penicillin antibiotic flucloxacillin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.963555

A role for the pregnane X receptor in flucloxacillin-induced liver injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.963555

Indirect cytotoxicity of flucloxacillin toward human biliary epithelium via metabolite formation in hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.963555

Immunochemical detection of flucloxacillin adduct formation in livers of treated rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.963555

Metabolic activation of troglitazone: identification of a reactive metabolite and mechanisms involved

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.963555

A pharmacophore for human pregnane X receptor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.963555

Induction of Human CYP2C9 by Rifampicin, Hyperforin, and Phenobarbital Is Mediated by the Pregnane X Receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.963555

Activation of human CYP2C9 promoter and regulation by CAR and PXR in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.963555

CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.963555

Cellular imaging predictions of clinical drug-induced liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.963555

3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.963555

A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.963555

Orphan nuclear receptor pregnane X receptor sensitizes oxidative stress responses in transgenic mice and cancerous cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.963555

The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.963555

Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.963555

The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.963555

A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.963555

Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata1,2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.963555

Development of a real-time in vivo transcription assay: application reveals pregnane X receptor-mediated induction of CYP3A4 by cancer chemotherapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.963555

Post-transcriptional regulation of human pregnane X receptor by micro-RNA affects the expression of cytochrome P450 3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.963555

A phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pregnane x receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.963555

The influence of common gene variants of the xenobiotic receptor (PXR) in genetic susceptibility to intrahepatic cholestasis of pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.963555

The nuclear receptor PXR gene variants are associated with liver injury in nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.963555

Role of the nuclear receptor pregnane X receptor in acetaminophen hepatotoxicity

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198438

Role of transport proteins in drug discovery and development: a pharmaceutical perspective

27 October 2018

1 reference

12 December 2020

Troglitazone hepatotoxicity: are we getting closer to understanding idiosyncratic liver injury?

1 reference

12 December 2020

Pregnane X receptor is a target of farnesoid X receptor

1 reference

12 December 2020

Hy's law: predicting serious hepatotoxicity

1 reference

12 December 2020

Identification of potential pharmacological and toxicological targets differentiating structural analogs by a combination of transcriptional profiling and promoter analysis in LS-180 and Caco-2 adenocarcinoma cell lines

1 reference

12 December 2020

The pregnane X receptor: from bench to bedside

1 reference

12 December 2020

Drug-induced liver disease

1 reference

12 December 2020

10.1517/17425255.2014.963555

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252616%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252616%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

PubMed publication ID

25252616

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25252616%20AND%20SRC:MED&resulttype=core&format=json