A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response. (Q36804898)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18677425%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

title

A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response (English)

1 reference

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11 January 2020

1

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11 January 2020

C Wolf

7

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11 January 2020

author name string

Jillian Ross

2

1 reference

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11 January 2020

Anja Rode

3

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11 January 2020

Branko Zevnik

4

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11 January 2020

Sandra Niehaves

5

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11 January 2020

Nicole Faust

6

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11 January 2020

language of work or name

English

0 references

publication date

1 September 2008

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Journal of Clinical Investigation

11 January 2020

published in

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11 January 2020

volume

118

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11 January 2020

issue

9

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11 January 2020

page(s)

3228-3239

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CAR2 displays unique ligand binding and RXRalpha heterodimerization characteristics

11 January 2020

cites work

1 reference

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PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity

29 September 2017

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A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway

29 September 2017

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Distribution of cytochrome P450 2C, 2E1, 3A4, and 3A5 in human colon mucosa

29 September 2017

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Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver

29 September 2017

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Orphan nuclear receptor-mediated xenobiotic regulation in drug metabolism

29 September 2017

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Alternative splicing affects the function and tissue-specific expression of the human constitutive androstane receptor

29 September 2017

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Human PXR variants and their differential effects on the regulation of human UDP-glucuronosyltransferase gene expression.

29 September 2017

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Protein measurement with the Folin phenol reagent

29 September 2017

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Alternatively spliced isoforms of the human constitutive androstane receptor

29 September 2017

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Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes

29 September 2017

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Identification of the novel splicing variants for the hPXR in human livers

29 September 2017

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Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR

29 September 2017

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The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism

29 September 2017

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The peptide near the C terminus regulates receptor CAR nuclear translocation induced by xenochemicals in mouse liver

29 September 2017

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The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

29 September 2017

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A phage integrase directs efficient site-specific integration in human cells

29 September 2017

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The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR

29 September 2017

1 reference

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Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

29 September 2017

1 reference

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The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

29 September 2017

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29 September 2017

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The human orphan receptor PXR messenger RNA is expressed in both normal and neoplastic breast tissue

29 September 2017

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The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

29 September 2017

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SXR, a novel steroid and xenobiotic-sensing nuclear receptor

29 September 2017

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A new logic for DNA engineering using recombination in Escherichia coli

29 September 2017

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Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

29 September 2017

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The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

29 September 2017

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29 September 2017

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A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements

29 September 2017

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Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins

29 September 2017

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29 September 2017

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27 June 2018

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27 June 2018

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Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

27 June 2018

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Multiple forms of cytochrome P-450 related to forms induced marginally by phenobarbital. Differences in structure and in the metabolism of alkoxyresorufins

27 June 2018

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Regulation of phenobarbital-inducible cytochrome P-450s in rat and mouse liver following dexamethasone administration and hypophysectomy

27 June 2018

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Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics

27 June 2018

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Rifaximin is a gut-specific human pregnane X receptor activator.

27 June 2018

1 reference

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The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A.

5 September 2018

1 reference

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Comparative cytochrome P450 -1A1, -2A6, -2B6, -2C, -2D6, -2E1, -3A5 and -4B1 expressions in human larynx tissue analysed at mRNA level.

5 September 2018

1 reference

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Directed evolution of mammalian cytochrome P450 2B1: mutations outside of the active site enhance the metabolism of several substrates, including the anticancer prodrugs cyclophosphamide and ifosfamide

5 September 2018

1 reference

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Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier

5 September 2018

1 reference

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Alternative splicing within the ligand binding domain of the human constitutive androstane receptor.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493444

7-Benzyloxyquinoline oxidation by P450eryF A245T: finding of a new fluorescent substrate probe

5 September 2018

1 reference

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1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, an extremely potent modulator of mouse hepatic cytochrome P-450 gene expression

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493444

Demonstration in multiple species of inducible hepatic cytochromes P-450 and their mRNAs related to the glucocorticoid-inducible cytochrome P-450 of the rat

5 September 2018

1 reference

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Species differences in responsiveness to 1,4-bis[2-(3,5-dichloropyridyloxy)]-benzene, a potent phenobarbital-like inducer of microsomal monooxygenase activity

20 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18677425

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The route of absorption of intraperitoneally administered compounds

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18677425

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI35483

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18677425%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18677425%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

PubMed publication ID

18677425

1 reference