Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects (Q34367481)

1 August 2017

Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects (English)

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1 August 2017

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Zhijian J Chen

6

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ORCID Public Data File 2021

Daxing Gao

3

object named as

Daxing Gao

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1 August 2017

Xiao-Dong Li

1

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1 August 2017

Jiaxi Wu

2

1 reference

1 August 2017

Hua Wang

4

1 reference

1 August 2017

Lijun Sun

5

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1 August 2017

language of work or name

English

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publication date

29 August 2013

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1 August 2017

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1 August 2017

341

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1 August 2017

1390-1394

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1 August 2017

6152

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Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

1 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3863637

cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3863637

The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3863637

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3863637

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3863637

Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3863637

Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3863637

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3863637

The STING pathway and regulation of innate immune signaling in response to DNA pathogens

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3863637

The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3863637

IFI16 is an innate immune sensor for intracellular DNA

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3863637

Pattern recognition receptors and inflammation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3863637

The potential of 3',5'-cyclic diguanylic acid (c-di-GMP) as an effective vaccine adjuvant

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3863637

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3863637

RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3863637

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3863637

Recognition of cytosolic DNA activates an IRF3-dependent innate immune response

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3863637

Herpes simplex virus 1 has multiple mechanisms for blocking virus-induced interferon production

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3863637

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3863637

Persistence and expression of the herpes simplex virus genome in the absence of immediate-early proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3863637

Immunology. Sensing the dark side of DNA.

6 July 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1244040

Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1244040

DNA released from dying host cells mediates aluminum adjuvant activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1244040

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1244040

21 January 2018

Identifiers

DOI

10.1126/SCIENCE.1244040

1 reference

1 August 2017

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1 August 2017

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