Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination (Q38021271)

27 August 2017

Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination (English)

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27 August 2017

2

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27 August 2017

Christophe J Desmet

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27 August 2017

22 June 2012

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Nature Reviews Immunology

27 August 2017

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27 August 2017

12

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27 August 2017

479-491

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27 August 2017

7

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Vaccine adjuvants: putting innate immunity to work

27 August 2017

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Immunological mechanisms of vaccination

31 March 2020

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Vaccines: correlates of vaccine-induced immunity

31 March 2020

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Regulation of adaptive immunity by the innate immune system

31 March 2020

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Innate recognition of viruses

31 March 2020

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Pattern recognition receptors and inflammation

31 March 2020

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Nucleic acid recognition by the innate immune system

31 March 2020

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Sterile inflammation: sensing and reacting to damage

31 March 2020

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Intracellular toll-like receptors

31 March 2020

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Toll-like receptors and their crosstalk with other innate receptors in infection and immunity

31 March 2020

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Immune signaling by RIG-I-like receptors

31 March 2020

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Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens

31 March 2020

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Toll-like receptor control of the adaptive immune responses

31 March 2020

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The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

31 March 2020

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The chase for the RIG-I ligand--recent advances

31 March 2020

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RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate

31 March 2020

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RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway

31 March 2020

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Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5

31 March 2020

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Small self-RNA generated by RNase L amplifies antiviral innate immunity

31 March 2020

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Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses

31 March 2020

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LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses

31 March 2020

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Identification of host cytosolic sensors and bacterial factors regulating the type I interferon response to Legionella pneumophila

31 March 2020

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Mitochondrial antiviral signaling protein (MAVS) monitors commensal bacteria and induces an immune response that prevents experimental colitis

31 March 2020

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Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production

31 March 2020

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STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

31 March 2020

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The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation

31 March 2020

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DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta-inducing potential

31 March 2020

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DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells

31 March 2020

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DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling

31 March 2020

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Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells

31 March 2020

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The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

31 March 2020

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DHX9 pairs with IPS-1 to sense double-stranded RNA in myeloid dendritic cells

31 March 2020

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Regulation of the antimicrobial response by NLR proteins.

31 March 2020

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Activation of innate immune antiviral responses by Nod2

31 March 2020

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Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA

31 March 2020

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The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA.

31 March 2020

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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

31 March 2020

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Cytosolic DNA sensors regulating type I interferon induction.

31 March 2020

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An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

31 March 2020

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AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

31 March 2020

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AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

31 March 2020

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HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA

31 March 2020

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IFI16 is an innate immune sensor for intracellular DNA

31 March 2020

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IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection

31 March 2020

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DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

31 March 2020

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Receptor-interacting protein homotypic interaction motif-dependent control of NF-kappa B activation via the DNA-dependent activator of IFN regulatory factors

31 March 2020

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TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

31 March 2020

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The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway

31 March 2020

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STING is a direct innate immune sensor of cyclic di-GMP

31 March 2020

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Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity

31 March 2020

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Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses

31 March 2020

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Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans

31 March 2020

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Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans

31 March 2020

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Survival of lethal poxvirus infection in mice depends on TLR9, and therapeutic vaccination provides protection

31 March 2020

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Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome

31 March 2020

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Innate immunity against vaccinia virus is mediated by TLR2 and requires TLR-independent production of IFN-beta

31 March 2020

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A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infection

31 March 2020

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Toll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNA

31 March 2020

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Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

31 March 2020

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Recognition of single-stranded RNA viruses by Toll-like receptor 7

31 March 2020

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The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

31 March 2020

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Cell type-specific involvement of RIG-I in antiviral response

31 March 2020

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The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1

31 March 2020

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Plasmacytoid dendritic cells delineate immunogenicity of influenza vaccine subtypes

31 March 2020

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Innate and adaptive immune responses to viral infection and vaccination

31 March 2020

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Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells.

31 March 2020

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Toll-like receptor 9 contributes to recognition of Mycobacterium bovis Bacillus Calmette-Guérin by Flt3-ligand generated dendritic cells

31 March 2020

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Detection of prokaryotic mRNA signifies microbial viability and promotes immunity

31 March 2020

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Immunologic basis of vaccine vectors

31 March 2020

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Novel strategies to improve DNA vaccine immunogenicity

31 March 2020

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Vaccination with plasmid DNA activates dendritic cells via Toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice

31 March 2020

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TLR9-/- and TLR9+/+ mice display similar immune responses to a DNA vaccine.

31 March 2020

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Essential role for TLR9 in prime but not prime-boost plasmid DNA vaccination to activate dendritic cells and protect from lethal viral infection

31 March 2020

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STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

31 March 2020

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New adjuvants for human vaccines

31 March 2020

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Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity

31 March 2020

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Towards an understanding of the adjuvant action of aluminium

31 March 2020

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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

31 March 2020

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Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

31 March 2020

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The controversial relationship between NLRP3, alum, danger signals and the next-generation adjuvants.

31 March 2020

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Local tissue irritating effects and adjuvant activities of calcium phosphate and aluminium hydroxide with different physical properties

31 March 2020

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Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo

31 March 2020

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Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells

31 March 2020

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An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma.

31 March 2020

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DNA released from dying host cells mediates aluminum adjuvant activity

31 March 2020

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Toll-Like Receptor Ligands Modulate Dendritic Cells to Augment Cytomegalovirus- and HIV-1-Specific T Cell Responses

31 March 2020

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Toll-like receptor 3 promotes cross-priming to virus-infected cells.

31 March 2020

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Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens.

31 March 2020

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TLR3-specific double-stranded RNA oligonucleotide adjuvants induce dendritic cell cross-presentation, CTL responses, and antiviral protection

31 March 2020

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Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells

31 March 2020

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The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccine

31 March 2020

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Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant

31 March 2020

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Synthetic double-stranded RNAs are adjuvants for the induction of T helper 1 and humoral immune responses to human papillomavirus in rhesus macaques

31 March 2020

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Cutting edge: cooperation of IPS-1- and TRIF-dependent pathways in poly IC-enhanced antibody production and cytotoxic T cell responses

31 March 2020

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Poly(I:C) is an effective adjuvant for antibody and multi-functional CD4+ T cell responses to Plasmodium falciparum circumsporozoite protein (CSP) and αDEC-CSP in non human primates

31 March 2020

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Cutting edge: polyinosinic:polycytidylic acid boosts the generation of memory CD8 T cells through melanoma differentiation-associated protein 5 expressed in stromal cells.

31 March 2020

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Small molecule Toll-like receptor 7 agonists localize to the MHC class II loading compartment of human plasmacytoid dendritic cells.

31 March 2020

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Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells

31 March 2020

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Immunostimulatory RNA is a potent inducer of antigen-specific cytotoxic and humoral immune response in vivo

31 March 2020

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Immunization with a Toll-like receptor 7 and/or 8 agonist vaccine adjuvant increases protective immunity against Leishmania major in BALB/c mice

31 March 2020

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Plasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists

31 March 2020

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HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates

31 March 2020

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Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets.

31 March 2020

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Targeting the TLR9-MyD88 pathway in the regulation of adaptive immune responses

31 March 2020

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CpG-containing immunostimulatory DNA sequences elicit TNF-alpha-dependent toxicity in rodents but not in humans

31 March 2020

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IL-12p70-dependent Th1 induction by human B cells requires combined activation with CD40 ligand and CpG DNA.

31 March 2020

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Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help.

31 March 2020

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CpG motifs in bacterial DNA trigger direct B-cell activation

31 March 2020

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The potential of 3',5'-cyclic diguanylic acid (c-di-GMP) as an effective vaccine adjuvant

31 March 2020

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Bacterial c-di-GMP is an immunostimulatory molecule

31 March 2020

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A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

31 March 2020

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The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides

31 March 2020

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Cooperation of Toll-like receptor signals in innate immune defence

31 March 2020

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Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: implications for vaccines

31 March 2020

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Using 3 TLR ligands as a combination adjuvant induces qualitative changes in T cell responses needed for antiviral protection in mice

31 March 2020

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Programming the magnitude and persistence of antibody responses with innate immunity

31 March 2020

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Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality

31 March 2020

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Dendritic cell and macrophage heterogeneity in vivo

31 March 2020

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Designing vaccines based on biology of human dendritic cell subsets

31 March 2020

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Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases.

31 March 2020

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Plasmacytoid dendritic cells are crucial for the initiation of inflammation and T cell immunity in vivo

31 March 2020

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Plasmacytoid dendritic cells: one-trick ponies or workhorses of the immune system?

31 March 2020

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Approaching the asymptote? Evolution and revolution in immunology

31 March 2020

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Tolerance, danger, and the extended family

31 March 2020

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Immunomodulatory functions of type I interferons

31 March 2020

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Interferon-inducible antiviral effectors

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI3247

1 reference

release_m36auj2w2bhaxjgnssu5jgkmdm

27 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/m36auj2w2bhaxjgnssu5jgkmdm

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

22728526

1 reference

PubMed ID

22728526