The impact energy metabolism and genome maintenance have on longevity and senescence: lessons from yeast to mammals (Q34369810)

1 August 2017

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title

The impact energy metabolism and genome maintenance have on longevity and senescence: lessons from yeast to mammals (English)

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1 August 2017

P Hasty

1

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1 August 2017

publication date

1 October 2001

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Mechanisms of Ageing and Development

1 August 2017

published in

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1 August 2017

volume

122

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1 August 2017

issue

15

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1 August 2017

page(s)

1651-1662

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DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes

1 August 2017

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Ku binds telomeric DNA in vitro

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DNA damage, mutation and fine structure DNA repair in aging.

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Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing

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7 January 2021

Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast

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7 January 2021

Effect of diet restriction on some biochemical parameters related to aging in mice

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7 January 2021

Effect of age and extent of dietary restriction on hepatic microsomal lipid peroxidation potential in mice.

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7 January 2021

Some biochemical parameters of ageing in relation to dietary protein

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7 January 2021

Elimination of replication block protein Fob1 extends the life span of yeast mother cells.

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7 January 2021

Dietary restriction reduces fluorescent age pigment accumulation in mice

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7 January 2021

A Review of its Symptomatology, Natural History, Pathologic Features, Genetics And Relationship to the Natural Aging Process

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7 January 2021

Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination.

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7 January 2021

Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity

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7 January 2021

Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

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7 January 2021

A genetic study of x-ray sensitive mutants in yeast

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7 January 2021

A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA.

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7 January 2021

Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription

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7 January 2021

The Werner syndrome protein is a DNA helicase

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7 January 2021

Diverse and dynamic functions of the Sir silencing complex

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7 January 2021

Genetic pathways that regulate ageing in model organisms

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7 January 2021

Telomeres shorten during ageing of human fibroblasts

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7 January 2021

Aging: a theory based on free radical and radiation chemistry

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7 January 2021

Ku is associated with the telomere in mammals

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7 January 2021

The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease

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7 January 2021

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

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7 January 2021

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

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7 January 2021

Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span

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7 January 2021

Mutation in the silencing gene S/R4 can delay aging in S. cerevisiae

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7 January 2021

Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae.

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7 January 2021

Anti-lipoperoxidation action of food restriction

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7 January 2021

The genetics of caloric restriction in Caenorhabditis elegans

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7 January 2021

Food restriction and membrane fluidity

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7 January 2021

Chromosomal double-strand break repair in Ku80-deficient cells

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7 January 2021

Warner-Lambert/Parke-Davis Award Lecture. Pathological and physiological double-strand breaks: roles in cancer, aging, and the immune system

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7 January 2021

A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53

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7 January 2021

Analysis of ku80-mutant mice and cells with deficient levels of p53

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7 January 2021

Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae

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7 January 2021

Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast

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7 January 2021

Caloric restriction and aging: an update

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7 January 2021

A role for histone acetylation in the developmental regulation of VDJ recombination.

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7 January 2021

Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae

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7 January 2021

Life span of individual yeast cells

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7 January 2021

Parental age and the life-span of zygotes of Saccharomyces cerevisiae

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7 January 2021

Calendar life span versus budding life span of Saccharomyces cerevisiae

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7 January 2021

Telomere maintenance is dependent on activities required for end repair of double-strand breaks

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7 January 2021

Effects of mutations in DNA repair genes on formation of ribosomal DNA circles and life span in Saccharomyces cerevisiae

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7 January 2021

Siblings of centenarians live longer

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7 January 2021

Diet restriction: a tool to prolong the lifespan of experimental animals. Model and current hypothesis of action

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7 January 2021

Effect of dietary restriction on the age-dependent changes in the expression of antioxidant enzymes in rat liver

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7 January 2021

Calorie restriction in primates: will it work and how will we know?

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7 January 2021

The conserved core of a human SIR2 homologue functions in yeast silencing

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7 January 2021

Extrachromosomal rDNA circles--a cause of aging in yeast

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7 January 2021

Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants

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7 January 2021

Loss of transcriptional silencing causes sterility in old mother cells of S. cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900294-9

7 January 2021

An unusual form of transcriptional silencing in yeast ribosomal DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900294-9

7 January 2021

Relationship between antioxidants, prooxidants, and the aging process

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900294-9

7 January 2021

Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900294-9

7 January 2021

Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

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https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900294-9

7 January 2021

Recombination factors of Saccharomyces cerevisiae

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https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900294-9

7 January 2021

Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900294-9

7 January 2021

An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900294-9

7 January 2021

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900294-9

7 January 2021

Silencing factors participate in DNA repair and recombination in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900294-9

7 January 2021

Deletion of Ku86 causes early onset of senescence in mice

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https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900294-9

7 January 2021

Dietary restriction and aging: historical phases, mechanisms and current directions

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https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900294-9

7 January 2021

PLEIOTROPY, NATURAL SELECTION, AND THE EVOLUTION OF SENESCENCE

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7 January 2021

Chromosomal landscape of nucleosome-dependent gene expression and silencing in yeast.

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7 January 2021

Protein restriction (PR) and caloric restriction (CR) compared: effects on DNA damage, carcinogenesis, and oxidative damage

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7 January 2021

Protein oxidation associated with aging is reduced by dietary restriction of protein or calories

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7 January 2021

Positional cloning of the Werner's syndrome gene

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7 January 2021

10.1016/S0047-6374(01)00294-9

Identifiers

DOI

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1 August 2017

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