Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F. (Q34375134)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25288396%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

title

Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F (English)

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20 February 2020

2

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20 February 2020

Markus G Manz

8

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20 February 2020

author name string

Pontus Lundberg

1

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20 February 2020

Lucia Kubovcakova

3

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20 February 2020

Guoji Guo

4

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20 February 2020

Hui Hao-Shen

5

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20 February 2020

Stephan Dirnhofer

6

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20 February 2020

Stuart H Orkin

7

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20 February 2020

Radek C Skoda

9

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20 February 2020

language of work or name

English

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publication date

6 October 2014

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Journal of Experimental Medicine

20 February 2020

published in

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20 February 2020

volume

211

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20 February 2020

issue

11

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20 February 2020

page(s)

2213-2230

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Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2

20 February 2020

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FLT3-ITD knockin impairs hematopoietic stem cell quiescence/homeostasis, leading to myeloproliferative neoplasm

6 July 2018

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Distinct roles for long-term hematopoietic stem cells and erythroid precursor cells in a murine model of Jak2V617F-mediated polycythemia vera

6 July 2018

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Mouse models of myeloproliferative neoplasms: JAK of all grades

6 July 2018

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DNMT3A mutational analysis in primary myelofibrosis, chronic myelomonocytic leukemia and advanced phases of myeloproliferative neoplasms

6 July 2018

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6 July 2018

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The JAK2 V617F somatic mutation, mortality and cancer risk in the general population

6 July 2018

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Distinct clinical phenotypes associated with JAK2V617F reflect differential STAT1 signaling

6 July 2018

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Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

6 July 2018

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Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells

6 July 2018

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JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia

6 July 2018

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Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment.

6 July 2018

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Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms.

6 July 2018

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Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease

6 July 2018

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BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells

6 July 2018

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CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells.

6 July 2018

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Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms

6 July 2018

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6 July 2018

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JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms

6 July 2018

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6 July 2018

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JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders.

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia

6 July 2018

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The hematopoietic stem compartment consists of a limited number of discrete stem cell subsets

6 July 2018

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6 July 2018

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A gain-of-function mutation of JAK2 in myeloproliferative disorders

6 July 2018

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Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

6 July 2018

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A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

6 July 2018

1 reference

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Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

6 July 2018

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The purification and characterization of fetal liver hematopoietic stem cells.

6 July 2018

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Purification and characterization of mouse hematopoietic stem cells

6 July 2018

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Clonal diversity in the myeloproliferative neoplasms: independent origins of genetically distinct clones

6 July 2018

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Mutations of ASXL1 gene in myeloproliferative neoplasms.

21 January 2018

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CD41 expression marks myeloid-biased adult hematopoietic stem cells and increases with age.

21 January 2018

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https://api.crossref.org/works/10.1084%2FJEM.20131371

JAK2V617F expression in mice amplifies early hematopoietic cells and gives them a competitive advantage that is hampered by IFNα.

21 January 2018

1 reference

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Acquisition of the V617F mutation of JAK2 is a late genetic event in a subset of patients with myeloproliferative disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20131371

Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms.

21 January 2018

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Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knock-in mice.

21 January 2018

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A common JAK2 haplotype confers susceptibility to myeloproliferative neoplasms.

21 January 2018

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Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy.

21 January 2018

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Observation of Antigen-Dependent CD8+ T-Cell/ Dendritic Cell Interactions in Vivo

21 January 2018

1 reference

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Clonal analysis of deletions on chromosome 20q and JAK2-V617F in MPD suggests that del20q acts independently and is not one of the predisposing mutations for JAK2-V617F.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20131371

Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20131371

Progenitors homozygous for the V617F mutation occur in most patients with polycythemia vera, but not essential thrombocythemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20131371

Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice

21 January 2018

1 reference

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Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells

21 January 2018

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Leukaemia disease genes: large-scale cloning and pathway predictions

21 January 2018

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Expression of CD27 on murine hematopoietic stem and progenitor cells

27 October 2018

1 reference

12 December 2020

Numbers and dispersion of repopulating hematopoietic cell clones in radiation chimeras as functions of injected cell dose

1 reference

12 December 2020

Phenotypic and functional changes induced at the clonal level in hematopoietic stem cells after 5-fluorouracil treatment

1 reference

12 December 2020

The JAK2V617F mutation is detectable at very low level in peripheral blood of healthy donors

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12 December 2020

Hematopoietic stem cell subtypes expand differentially during development and display distinct lymphopoietic programs

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12 December 2020

Anti-CD47 antibodies promote phagocytosis and inhibit the growth of human myeloma cells

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12 December 2020

Identifiers

DOI

10.1084/JEM.20131371

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25288396%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25288396%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25288396%20AND%20SRC:MED&resulttype=core&format=json