Reduced Alzheimer's disease ß-amyloid deposition in transgenic mice expressing S-palmitoylation-deficient APH1aL and nicastrin (Q34390470)

1 August 2017

title

Reduced Alzheimer's disease ß-amyloid deposition in transgenic mice expressing S-palmitoylation-deficient APH1aL and nicastrin (English)

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1 August 2017

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Xavier Meckler

1

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1 August 2017

Jelita Roseman

2

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1 August 2017

Pritam Das

3

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1 August 2017

Haipeng Cheng

4

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1 August 2017

Susan Pei

5

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1 August 2017

Marcia Keat

6

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1 August 2017

Breanne Kassarjian

7

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1 August 2017

Todd E Golde

8

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1 August 2017

Angèle T Parent

9

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1 August 2017

Gopal Thinakaran

10

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1 August 2017

language of work or name

English

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publication date

1 December 2010

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1 August 2017

published in

Journal of Neuroscience

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1 August 2017

volume

30

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1 August 2017

issue

48

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1 August 2017

page(s)

16160-16169

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Dual role of alpha-secretase cleavage in the regulation of gamma-secretase activity for amyloid production

1 August 2017

cites work

1 reference

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Dual palmitoylation of NR2 subunits regulates NMDA receptor trafficking

6 July 2018

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Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95

6 July 2018

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Regulation of AMPA receptor extrasynaptic insertion by 4.1N, phosphorylation and palmitoylation

6 July 2018

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An exo-cell assay for examining real-time gamma-secretase activity and inhibition

6 July 2018

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Gender- and age-dependent gamma-secretase activity in mouse brain and its implication in sporadic Alzheimer disease

6 July 2018

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S-palmitoylation of gamma-secretase subunits nicastrin and APH-1

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Synaptic adhesion molecules and PSD-95.

6 July 2018

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Cellular distribution of gamma-secretase subunit nicastrin in the developing and adult rat brains

6 July 2018

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Palmitoylation: policing protein stability and traffic

6 July 2018

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Pathological and physiological functions of presenilins

6 July 2018

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Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model

6 July 2018

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Modulation of neuronal protein trafficking and function by palmitoylation

6 July 2018

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Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions.

6 July 2018

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Gamma-secretase complex assembly within the early secretory pathway

6 July 2018

1 reference

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The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity

6 July 2018

1 reference

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A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1.

6 July 2018

1 reference

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Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes

6 July 2018

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Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

6 July 2018

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γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

6 July 2018

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APP processing and synaptic function

6 July 2018

1 reference

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The role of presenilin cofactors in the gamma-secretase complex

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999009

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

6 July 2018

1 reference

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aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999009

Dual palmitoylation of PSD-95 mediates its vesiculotubular sorting, postsynaptic targeting, and ion channel clustering

6 July 2018

1 reference

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Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path

6 July 2018

1 reference

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Stable association of presenilin derivatives and absence of presenilin interactions with APP.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999009

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999009

Light and electron microscopic localization of presenilin-1 in primate brain.

6 July 2018

1 reference

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Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999009

Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.

6 July 2018

1 reference

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Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999009

Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999009

Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999009

Synaptic strength regulated by palmitate cycling on PSD-95.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999009

N-terminal palmitoylation of PSD-95 regulates association with cell membranes and interaction with K+ channel Kv1.4.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999009

Overexpression of the neural growth-associated protein GAP-43 induces nerve sprouting in the adult nervous system of transgenic mice

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21123562

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1523/JNEUROSCI.4436-10.2010

1 reference

1 August 2017

1 reference

1 August 2017

1 reference