Gamma-secretase complex assembly within the early secretory pathway (Q28297818)

3

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Dirk Beher

object named as

Dirk Beher

2

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Anja Capell

1

object named as

Anja Capell

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author name string

Harald Steiner

4

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Christoph Kaether

5

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Mark S Shearman

Journal of Biological Chemistry

6

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language of work or name

English

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publication date

25 February 2005

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published in

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volume

280

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page(s)

6471-8

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issue

8

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cites work

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Identification of signal peptide peptidase, a presenilin-type aspartic protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

The type 4 prepilin peptidases comprise a novel family of aspartic acid proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Reconstitution of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Endoproteolytic processing and stabilization of wild-type and mutant presenilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Gamma-secretase activity is associated with a conformational change of nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

The gamma-secretase complex: machinery for intramembrane proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Identification of distinct gamma-secretase complexes with different APH-1 variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200

Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409106200