P53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1 (Q34390794)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14634213%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

title

P53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1 (English)

1 reference

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21 December 2019

3

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21 December 2019

author name string

Gad Asher

1

1 reference

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21 December 2019

Joseph Lotem

2

1 reference

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21 December 2019

Veronica Reiss

4

1 reference

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21 December 2019

Leo Sachs

5

1 reference

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21 December 2019

Yosef Shaul

6

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21 December 2019

language of work or name

English

0 references

publication date

21 November 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14634213%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

21 December 2019

published in

1 reference

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21 December 2019

volume

100

1 reference

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21 December 2019

issue

25

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21 December 2019

page(s)

15065-15070

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14634213%20AND%20SRC:MED&resulttype=core&format=json

S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component

21 December 2019

cites work

1 reference

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Differential binding of NAD+ and NADH allows the transcriptional corepressor carboxyl-terminal binding protein to serve as a metabolic sensor

6 July 2018

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Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1.

6 July 2018

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Cytokine control of developmental programs in normal hematopoiesis and leukemia

6 July 2018

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NQO1 stabilizes p53 through a distinct pathway

6 July 2018

1 reference

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Regulation of corepressor function by nuclear NADH.

6 July 2018

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Characterization of a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1 by biochemical, X-ray crystallographic, and mass spectrometric approaches

6 July 2018

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hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

6 July 2018

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Negative control of p53 by Sir2alpha promotes cell survival under stress

6 July 2018

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Inhibition of MDM2 by hsp90 contributes to mutant p53 stabilization

6 July 2018

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Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1

6 July 2018

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6 July 2018

Surfing the p53 network

1 reference

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Structure-function studies of DT-diaphorase (NQO1) and NRH: quinone oxidoreductase (NQO2).

6 July 2018

1 reference

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The p53 tumor suppressor gene: from molecular biology to clinical investigation.

6 July 2018

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Molecular characterization of binding of substrates and inhibitors to DT-diaphorase: combined approach involving site-directed mutagenesis, inhibitor-binding analysis, and computer modeling

6 July 2018

1 reference

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage

6 July 2018

1 reference

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Regulation of Mdm2-directed degradation by the C terminus of p53.

6 July 2018

1 reference

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p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.

6 July 2018

1 reference

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Regulation of p53 stability by Mdm2

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=299908

Mdm2 promotes the rapid degradation of p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=299908

p53 gene mutation and integrated hepatitis B viral DNA sequences in human liver cancer cell lines

6 July 2018

1 reference

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NAD(P)H:quinone oxidoreductase1 (DT-diaphorase) expression in normal and tumor tissues

6 July 2018

1 reference

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Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=299908

How loops, beta sheets, and alpha helices help us to understand p53.

6 July 2018

1 reference

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Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential

6 July 2018

1 reference

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Database of p53 gene somatic mutations in human tumors and cell lines

6 July 2018

1 reference

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Properties and reaction mechanism of DT diaphorase from rat liver.

6 July 2018

1 reference

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Comparative study of the binding of coumarin anticoagulants and serum albumins.

6 July 2018

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Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53.

6 July 2018

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Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

6 July 2018

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NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity

6 July 2018

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Inhibition of NAD(P)H:(quinone-acceptor) oxidoreductase by Cibacron Blue and related anthraquinone dyes: a structure-activity study

6 July 2018

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Elevated DT-diaphorase activity and messenger RNA content in human non-small cell lung carcinoma: relationship to the response of lung tumor xenografts to mitomycin Cł

6 July 2018

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Interaction of human NAD(P)H:quinone oxidoreductase 1 (NQO1) with the tumor suppressor protein p53 in cells and cell-free systems

6 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.2436329100

Inhibition of NAD(P)H:quinone acceptor oxidoreductase by flavones: a structure-activity study

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.2436329100

Chaperone-like activity of alpha-crystallin. The effect of NADPH on its interaction with zeta-crystallin.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=299908

Stabilization of the MDM2 oncoprotein by mutant p53

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/14634213

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.2436329100

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14634213%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14634213%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

PubMed publication ID

14634213

1 reference