Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans (Q34398188)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20840584%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

title

Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans (English)

1 reference

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13 February 2020

1

1 reference

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13 February 2020

Liliana Schaefer

series ordinal

2

1 reference

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13 February 2020

2

Liliana Schaefer

1 reference

PubMed publication ID

1 August 2017

1

Renato V Iozzo

1 reference

PubMed publication ID

20840584

1 August 2017

language of work or name

English

0 references

publication date

31 August 2010

1 reference

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13 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20840584%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

volume

277

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13 February 2020

issue

19

1 reference

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13 February 2020

page(s)

3864-3875

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Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting.

13 February 2020

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Proteoglycans in health and disease: the multiple roles of syndecan shedding

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Biglycan and fibromodulin have essential roles in regulating chondrogenesis and extracellular matrix turnover in temporomandibular joint osteoarthritis

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Decorin suppresses prostate tumor growth through inhibition of epidermal growth factor and androgen receptor pathways

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6 July 2018

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A role for decorin in controlling proliferation, adhesion, and migration of murine embryonic fibroblasts

6 July 2018

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Extracellular matrix lumican deposited on the surface of neutrophils promotes migration by binding to beta2 integrin

6 July 2018

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Proteoglycans: from structural compounds to signaling molecules

6 July 2018

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6 July 2018

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Genetic evidence for key roles of decorin and biglycan in dentin mineralization.

6 July 2018

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Genetic evidence for the coordinated regulation of collagen fibrillogenesis in the cornea by decorin and biglycan

6 July 2018

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Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs.

6 July 2018

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Decorin-mediated inhibition of proliferation and migration of the human trophoblast via different tyrosine kinase receptors

6 July 2018

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Novel regulatory mechanisms for the proteoglycans decorin and biglycan during muscle formation and muscular dystrophy

6 July 2018

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An antimetastatic role for decorin in breast cancer.

6 July 2018

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Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation

6 July 2018

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Overexpression of decorin induces apoptosis and cell growth arrest in cultured rat mesangial cells in vitro

6 July 2018

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Decorin-induced growth inhibition is overcome through protracted expression and activation of epidermal growth factor receptors in osteosarcoma cells

6 July 2018

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Decorin suppresses lung metastases of murine osteosarcoma

6 July 2018

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Biological functions of the small leucine-rich proteoglycans: from genetics to signal transduction.

6 July 2018

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Role of decorin in the antimyeloma effects of osteoblasts

6 July 2018

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Influence of cyclic strain and decorin deficiency on 3D cellularized collagen matrices.

6 July 2018

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Identification of beta1 integrin as mediator of melanoma cell adhesion to lumican.

6 July 2018

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Keratocan and lumican regulate neutrophil infiltration and corneal clarity in lipopolysaccharide-induced keratitis by direct interaction with CXCL1.

6 July 2018

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Decorin deficiency enhances progressive nephropathy in diabetic mice.

6 July 2018

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6 July 2018

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The glycosaminoglycan chain of decorin plays an important role in collagen fibril formation at the early stages of fibrillogenesis

6 July 2018

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Decorin-mediated regulation of fibrillin-1 in the kidney involves the insulin-like growth factor-I receptor and Mammalian target of rapamycin

6 July 2018

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6 July 2018

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Lumican, a small leucine-rich proteoglycan substituted with keratan sulfate chains is expressed and secreted by human melanoma cells and not normal melanocytes.

6 July 2018

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Decorin protein core inhibits in vivo cancer growth and metabolism by hindering epidermal growth factor receptor function and triggering apoptosis via caspase-3 activation

6 July 2018

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Decorin regulates assembly of collagen fibrils and acquisition of biomechanical properties during tendon development

6 July 2018

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The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000440

Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis

6 July 2018

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Biglycan is a new extracellular component of the Chordin-BMP4 signaling pathway

6 July 2018

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Decorin prevents metastatic spreading of breast cancer.

6 July 2018

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Effects of ectopic decorin in modulating intracranial glioma progression in vivo, in a rat syngeneic model

6 July 2018

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Cleavage of lumican by membrane-type matrix metalloproteinase-1 abrogates this proteoglycan-mediated suppression of tumor cell colony formation in soft agar

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000440

The small leucine-rich proteoglycan biglycan modulates BMP-4-induced osteoblast differentiation

6 July 2018

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The small leucine-rich proteoglycan lumican inhibits melanoma progression

6 July 2018

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Biologically active decorin is a monomer in solution.

6 July 2018

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Functions of lumican and fibromodulin: lessons from knockout mice

6 July 2018

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The role of decorin in collagen fibrillogenesis and skin homeostasis

6 July 2018

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Mice deficient in small leucine-rich proteoglycans: novel in vivo models for osteoporosis, osteoarthritis, Ehlers-Danlos syndrome, muscular dystrophy, and corneal diseases

6 July 2018

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Decorin binds to a narrow region of the epidermal growth factor (EGF) receptor, partially overlapping but distinct from the EGF-binding epitope

6 July 2018

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Absence of decorin adversely influences tubulointerstitial fibrosis of the obstructed kidney by enhanced apoptosis and increased inflammatory reaction

6 July 2018

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Isolation of transformation suppressor genes by cDNA subtraction: lumican suppresses transformation induced by v-src and v-K-ras

6 July 2018

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The biology of the small leucine-rich proteoglycans. Functional network of interactive proteins

6 July 2018

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Cooperative action of germ-line mutations in decorin and p53 accelerates lymphoma tumorigenesis

6 July 2018

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Decorin is a biological ligand for the epidermal growth factor receptor

6 July 2018

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Matrix proteoglycans: from molecular design to cellular function

6 July 2018

1 reference

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Decorin suppresses tumor cell growth by activating the epidermal growth factor receptor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000440

Ectopic expression of decorin protein core causes a generalized growth suppression in neoplastic cells of various histogenetic origin and requires endogenous p21, an inhibitor of cyclin-dependent kinases

6 July 2018

1 reference

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The family of the small leucine-rich proteoglycans: key regulators of matrix assembly and cellular growth

6 July 2018

1 reference

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Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility

6 July 2018

1 reference

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Identification of a bimodal regulatory element encompassing a canonical AP-1 binding site in the proximal promoter region of the human decorin gene.

6 July 2018

1 reference

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Proteoglycans of the extracellular environment: clues from the gene and protein side offer novel perspectives in molecular diversity and function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000440

The human decorin gene: intron-exon organization, discovery of two alternatively spliced exons in the 5' untranslated region, and mapping of the gene to chromosome 12q23

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000440

Preferential gene expression in quiescent human lung fibroblasts

6 July 2018

1 reference

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Structural and functional characterization of the human decorin gene promoter. A homopurine-homopyrimidine S1 nuclease-sensitive region is involved in transcriptional control

6 July 2018

1 reference

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Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta

6 July 2018

1 reference

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The murine decorin. Complete cDNA cloning, genomic organization, chromosomal assignment, and expression during organogenesis and tissue differentiation

6 July 2018

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De novo decorin gene expression suppresses the malignant phenotype in human colon cancer cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000440

Expression of human proteoglycan in Chinese hamster ovary cells inhibits cell proliferation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000440

Negative regulation of transforming growth factor-beta by the proteoglycan decorin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000440

Suppression of tumorigenicity by adenovirus-mediated gene transfer of decorin

6 July 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07797.X

Decorin, a novel player in the insulin-like growth factor system.

21 January 2018

1 reference

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Fibrillin-1 regulates mesangial cell attachment, spreading, migration and proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07797.X

Decorin regulates endothelial cell motility on collagen I through activation of insulin-like growth factor I receptor and modulation of alpha2beta1 integrin activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07797.X

The low density lipoprotein receptor-related protein functions as an endocytic receptor for decorin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07797.X

Endocytosis of the dermatan sulfate proteoglycan decorin utilizes multiple pathways and is modulated by epidermal growth factor receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07797.X

Dermatan sulfate proteoglycan biglycan as a potential selectin L/CD44 ligand involved in selective recruitment of peripheral blood CD16(-) natural killer cells into human endometrium

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07797.X

Lumican suppresses cell proliferation and aids Fas-Fas ligand mediated apoptosis: implications in the cornea

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07797.X

Lumican regulates corneal inflammatory responses by modulating Fas-Fas ligand signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07797.X

Lumican core protein inhibits melanoma cell migration via alterations of focal adhesion complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07797.X

A novel role of the lumican core protein in bacterial lipopolysaccharide-induced innate immune response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07797.X

A role for decorin in the structural organization of periodontal ligament

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07797.X

A role for decorin in the remodeling of myocardial infarction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07797.X

A role for decorin in cutaneous wound healing and angiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07797.X

Extracellular matrix proteoglycans control the fate of bone marrow stromal cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07797.X

Alterations in lung mechanics in decorin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07797.X

Collagen fibril organization in the pregnant endometrium of decorin-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07797.X

A central role for decorin during vertebrate convergent extension

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07797.X

Decorin-transforming growth factor- interaction regulates matrix organization and mechanical characteristics of three-dimensional collagen matrices.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07797.X

Decorin gene delivery inhibits cardiac fibrosis in spontaneously hypertensive rats by modulation of transforming growth factor-beta/Smad and p38 mitogen-activated protein kinase signaling pathways

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000440

Effect of PEEP on induced constriction is enhanced in decorin-deficient mice.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000440

In vivo selective and distant killing of cancer cells using adenovirus-mediated decorin gene transfer.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000440

Lumican inhibits B16F1 melanoma cell lung metastasis

27 October 2018

1 reference

12 December 2020

Decorin suppresses tumor cell-mediated angiogenesis

1 reference

12 December 2020

Investigating Tendon Fascicle Structure–Function Relationships in a Transgenic-Age Mouse Model Using Multiple Regression Models

1 reference

12 December 2020

Transcriptional regulation of decorin gene expression. Induction by quiescence and repression by tumor necrosis factor-alpha

1 reference

12 December 2020

Decorin-induced Growth Suppression Is Associated with Up-regulation of p21, an Inhibitor of Cyclin-dependent Kinases

1 reference

12 December 2020

Macrophage receptors for lumican. A corneal keratan sulfate proteoglycan

1 reference

12 December 2020

Decorin Activates the Epidermal Growth Factor Receptor and Elevates Cytosolic Ca2+in A431 Carcinoma Cells

1 reference

12 December 2020

Transcriptional and posttranscriptional regulation of proteoglycan gene expression

1 reference

12 December 2020

Sustained down-regulation of the epidermal growth factor receptor by decorin. A mechanism for controlling tumor growth in vivo

1 reference

12 December 2020

An Anti-oncogenic Role for Decorin

1 reference

12 December 2020

Expression of lumican, a small leucine-rich proteoglycan with antitumour activity, in human malignant melanoma

1 reference

12 December 2020

Decorin-mediated effects in cancer cell biology

1 reference

12 December 2020

10.1111/J.1742-4658.2010.07797.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20840584%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20840584%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

PubMed publication ID

20840584

1 reference