Relaxin signals through a RXFP1-pERK-nNOS-NO-cGMP-dependent pathway to up-regulate matrix metalloproteinases: the additional involvement of iNOS. (Q34398874)

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English	Relaxin signals through a RXFP1-pERK-nNOS-NO-cGMP-dependent pathway to up-regulate matrix metalloproteinases: the additional involvement of iNOS.	scientific article

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12 February 2020

Relaxin signals through a RXFP1-pERK-nNOS-NO-cGMP-dependent pathway to up-regulate matrix metalloproteinases: the additional involvement of iNOS (English)

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12 February 2020

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12 February 2020

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12 February 2020

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12 February 2020

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Bryna Suet Man Chow

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12 February 2020

Chongxin Zhao

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12 February 2020

Chrishan S Samuel

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22 August 2012

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12 February 2020

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12 February 2020

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12 February 2020

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12 February 2020

e42714

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12 February 2020

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Creative Commons Attribution 4.0 International

22 August 2012

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0 references

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Drugs of the future: the hormone relaxin

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Relaxin as a cardiovascular hormone: physiology, pathophysiology and therapeutic promises

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Cross-talk between constitutive and inducible NO synthase: an update.

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Structure and function of matrix metalloproteinases and TIMPs

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The antifibrotic effects of relaxin in human renal fibroblasts are mediated in part by inhibition of the Smad2 pathway

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6 July 2018

Relaxin's induction of metalloproteinases is associated with the loss of collagen and glycosaminoglycans in synovial joint fibrocartilaginous explants

1 reference

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Relaxin's physiological roles and other diverse actions

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Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry

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Protective effect of relaxin in cardiac anaphylaxis: involvement of the nitric oxide pathway.

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Relaxin positively regulates matrix metalloproteinase expression in human lower uterine segment fibroblasts using a tyrosine kinase signaling pathway

1 reference

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Relaxin activates the L-arginine-nitric oxide pathway in vascular smooth muscle cells in culture

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1 reference

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Inhibition of myofibroblast apoptosis by transforming growth factor beta(1)

1 reference

https://pubmed.ncbi.nlm.nih.gov/22936987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relaxin ameliorates fibrosis in experimental diabetic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22936987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antifibrotic properties of relaxin: in vivo mechanism of action in experimental renal tubulointerstitial fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22936987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

H3 relaxin demonstrates antifibrotic properties via the RXFP1 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/22936987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Matrix metalloproteinase-2 ablation in dystrophin-deficient mdx muscles reduces angiogenesis resulting in impaired growth of regenerated muscle fibers

1 reference

https://pubmed.ncbi.nlm.nih.gov/22936987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relaxin remodels fibrotic healing following myocardial infarction

1 reference

https://pubmed.ncbi.nlm.nih.gov/22936987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relaxin deficiency in mice is associated with an age-related progression of pulmonary fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22936987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relaxin down-regulates renal fibroblast function and promotes matrix remodelling in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/22936987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

31 Quantification of matrix metalloproteinases in tissue samples

1 reference

https://pubmed.ncbi.nlm.nih.gov/22936987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of interstitial fibrosis in obstructive nephropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22936987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1371/JOURNAL.PONE.0042714

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22936987%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

2012PLoSO...742714C

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22936987%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22936987%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

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