MI-219-zinc combination: a new paradigm in MDM2 inhibitor-based therapy (Q34400398)

1 August 2017

title

MI-219-zinc combination: a new paradigm in MDM2 inhibitor-based therapy (English)

1 reference

1 August 2017

1

A. S. Azmi

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20818437

7 July 2024

author name string

P. A. Philip

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20818437

7 July 2024

F. W J. Beck

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20818437

7 July 2024

Z. Wang

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20818437

7 July 2024

S. Banerjee

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20818437

7 July 2024

S. Wang

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20818437

7 July 2024

D. Yang

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20818437

7 July 2024

F. H. Sarkar

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20818437

7 July 2024

R. M. Mohammad

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20818437

7 July 2024

language of work or name

English

0 references

publication date

6 September 2010

1 reference

full work available at URL

1 August 2017

https://europepmc.org/articles/pmc3000878?pdf=render

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20818437

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20818437/?tool=EBI

7 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20818437

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20818437/pdf/?tool=EBI

7 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20818437

https://europepmc.org/articles/PMC3000878

7 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20818437

https://europepmc.org/articles/PMC3000878?pdf=render

7 July 2024

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20818437

https://www.nature.com/articles/onc2010403.pdf

7 July 2024

https://api.crossref.org/works/10.1038/ONC.2010.403

1 reference

https://www.nature.com/articles/onc2010403

7 July 2024

1 reference

https://api.crossref.org/works/10.1038/ONC.2010.403

7 July 2024

1 reference

1 August 2017

volume

30

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1 August 2017

issue

1

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1 August 2017

page(s)

117-126

1 reference

MDM2 inhibitor MI-319 in combination with cisplatin is an effective treatment for pancreatic cancer independent of p53 function

1 August 2017

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Critical role of prostate apoptosis response-4 in determining the sensitivity of pancreatic cancer cells to small-molecule inhibitor-induced apoptosis

6 July 2018

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6 July 2018

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Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

6 July 2018

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Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation

6 July 2018

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6 July 2018

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Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation

6 July 2018

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Toxic effect of zinc on NF-kappaB, IL-2, IL-2 receptor alpha, and TNF-alpha in HUT-78 (Th(0)) cells

6 July 2018

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Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction.

6 July 2018

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Nuclear accumulations of p53 and Mdm2 are accompanied by reductions in c-Abl and p300 in zinc-depleted human hepatoblastoma cells

6 July 2018

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Zinc deficiency, DNA damage and cancer risk

6 July 2018

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Zinc deficiency: its characterization and treatment.

6 July 2018

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Differential expression of hZnT-4 in human prostate tissues

6 July 2018

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The importance of p53 location: nuclear or cytoplasmic zip code?

6 July 2018

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Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFkappa B, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line

6 July 2018

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Zinc enhances the expression of interleukin-2 and interleukin-2 receptors in HUT-78 cells by way of NF-kappaB activation

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Structure, function, and aggregation of the zinc-free form of the p53 DNA binding domain

6 July 2018

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Requirement of nuclear localization and transcriptional activity of p53 for its targeting to the yolk syncytial layer (YSL) nuclei in zebrafish embryo and its use for apoptosis assay

21 January 2018

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Structure-based design of potent non-peptide MDM2 inhibitors

21 January 2018

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21 January 2018

Turning the key on p53.

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Multisite phosphorylation and the integration of stress signals at p53.

21 January 2018

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Modulation of p53 protein conformation and DNA-binding activity by intracellular chelation of zinc.

21 January 2018

1 reference

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International Zinc Nutrition Consultative Group (IZiNCG) technical document #1. Assessment of the risk of zinc deficiency in populations and options for its control.

21 January 2018

1 reference

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Zn(2+)-dependent misfolding of the p53 DNA binding domain

27 October 2018

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Evaluation of zinc metabolism with use of stable-isotope techniques: implications for the assessment of zinc status

31 March 2020

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Metalloregulation of the tumor suppressor protein p53: zinc mediates the renaturation of p53 after exposure to metal chelators in vitro and in intact cells

31 March 2020

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The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots

31 March 2020

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Discovery of human zinc deficiency: impact on human health

31 March 2020

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Dual-site regulation of MDM2 E3-ubiquitin ligase activity

31 March 2020

1 reference

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Flux of intracellular labile zinc during apoptosis (gene-directed cell death) revealed by a specific chemical probe, Zinquin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.403

31 March 2020

Identifiers

DOI

10.1038/ONC.2010.403

1 reference

Dimensions Publication ID

1 August 2017

0 references

1 reference

1 August 2017

1 reference