MI-219-zinc combination: a new paradigm in MDM2 inhibitor-based therapy (Q34400398)

1 August 2017

MI-219-zinc combination: a new paradigm in MDM2 inhibitor-based therapy (English)

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1 August 2017

A S Azmi

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1 August 2017

P A Philip

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1 August 2017

F W J Beck

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1 August 2017

Z Wang

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1 August 2017

S Banerjee

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1 August 2017

S Wang

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1 August 2017

D Yang

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1 August 2017

F H Sarkar

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1 August 2017

R M Mohammad

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1 August 2017

language of work or name

English

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publication date

6 September 2010

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1 August 2017

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30

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1 August 2017

1

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1 August 2017

117-126

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https://scigraph.springernature.com/pub.10.1038/onc.2010.403

1 August 2017

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cites work

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Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation

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Toxic effect of zinc on NF-kappaB, IL-2, IL-2 receptor alpha, and TNF-alpha in HUT-78 (Th(0)) cells

6 July 2018

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Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction.

6 July 2018

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Nuclear accumulations of p53 and Mdm2 are accompanied by reductions in c-Abl and p300 in zinc-depleted human hepatoblastoma cells

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFkappa B, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line

6 July 2018

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Zinc enhances the expression of interleukin-2 and interleukin-2 receptors in HUT-78 cells by way of NF-kappaB activation

6 July 2018

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Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics

6 July 2018

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Zinc activates NF-kappaB in HUT-78 cells

6 July 2018

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Metal ions as regulators of the conformation and function of the tumour suppressor protein p53: implications for carcinogenesis.

6 July 2018

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Regulation of p53 stability by Mdm2

6 July 2018

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The cell cycle and cancer

6 July 2018

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p53, the cellular gatekeeper for growth and division

6 July 2018

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The spectrum of mutations at the p53 locus. Evidence for tissue-specific mutagenesis, selection of mutant alleles, and a "gain of function" phenotype

6 July 2018

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6 July 2018

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A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein

6 July 2018

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Correlation of apoptosis with change in intracellular labile Zn(II) using zinquin [(2-methyl-8-p-toluenesulphonamido-6-quinolyloxy)acetic acid], a new specific fluorescent probe for Zn(II).

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000878

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000878

Structural Biology of Zinc

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000878

Structure, function, and aggregation of the zinc-free form of the p53 DNA binding domain

6 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.403

Requirement of nuclear localization and transcriptional activity of p53 for its targeting to the yolk syncytial layer (YSL) nuclei in zebrafish embryo and its use for apoptosis assay.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.403

Structure-based design of potent non-peptide MDM2 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.403

21 January 2018

Turning the key on p53.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.403

Multisite phosphorylation and the integration of stress signals at p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.403

Modulation of p53 protein conformation and DNA-binding activity by intracellular chelation of zinc.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.403

International Zinc Nutrition Consultative Group (IZiNCG) technical document #1. Assessment of the risk of zinc deficiency in populations and options for its control.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000878

Zn(2+)-dependent misfolding of the p53 DNA binding domain

27 October 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.403

Evaluation of zinc metabolism with use of stable-isotope techniques: implications for the assessment of zinc status

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.403

Metalloregulation of the tumor suppressor protein p53: zinc mediates the renaturation of p53 after exposure to metal chelators in vitro and in intact cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.403

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.403

Discovery of human zinc deficiency: impact on human health

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.403

Dual-site regulation of MDM2 E3-ubiquitin ligase activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.403

Flux of intracellular labile zinc during apoptosis (gene-directed cell death) revealed by a specific chemical probe, Zinquin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.403

31 March 2020

Identifiers

DOI

10.1038/ONC.2010.403

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Dimensions Publication ID

1 August 2017

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1 August 2017

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