Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life (Q34408072)

24591609

2 August 2017

title

Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life (English)

1 reference

2 August 2017

1

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8 June 2020

Gareth S A Wright

2

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8 June 2020

Seiji Watanabe

3

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8 June 2020

Svetlana Antonyuk

5

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8 June 2020

Koji Yamanaka

6

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8 June 2020

author name string

J Günter Grossmann

4

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8 June 2020

S Samar Hasnain

7

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8 June 2020

language of work or name

English

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publication date

3 March 2014

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24591609

Proceedings of the National Academy of Sciences of the United States of America

2 August 2017

published in

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volume

111

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issue

11

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8 June 2020

page(s)

4309-4314

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Reducing TDP-43 aggregation does not prevent its cytotoxicity

8 June 2020

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6 July 2018

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TDP-43 regulates its mRNA levels through a negative feedback loop

6 July 2018

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Phosphorylation regulates proteasomal-mediated degradation and solubility of TAR DNA binding protein-43 C-terminal fragments

6 July 2018

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ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.

6 July 2018

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6 July 2018

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TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration

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Phosphorylated and cleaved TDP-43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathy

6 July 2018

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The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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CRYSOL– a Program to Evaluate X-ray Solution Scattering of Biological Macromolecules from Atomic Coordinates

21 January 2018

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21 January 2018

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21 January 2018

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27 October 2018

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12 December 2020

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Identifiers

DOI

10.1073/PNAS.1317317111

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24591609%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

0 references

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8 June 2020

24591609

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