LEOPARD syndrome-associated SHP2 mutation confers leanness and protection from diet-induced obesity (Q34409247)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25288766%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

title

LEOPARD syndrome-associated SHP2 mutation confers leanness and protection from diet-induced obesity (English)

1 reference

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20 February 2020

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13

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20 February 2020

Patrick Raynal

17

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20 February 2020

Hélène Cavé

18

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20 February 2020

Thomas Edouard

19

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20 February 2020

Philippe Valet

20

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20 February 2020

Armelle Yart

21

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20 February 2020

author name string

Mylène Tajan

1

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20 February 2020

Aurélie Batut

2

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20 February 2020

Thomas Cadoudal

3

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20 February 2020

Simon Deleruyelle

4

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20 February 2020

Sophie Le Gonidec

5

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20 February 2020

Céline Saint Laurent

6

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20 February 2020

Maëlle Vomscheid

7

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20 February 2020

Estelle Wanecq

8

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20 February 2020

Karine Tréguer

9

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20 February 2020

Audrey De Rocca Serra-Nédélec

10

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20 February 2020

Claire Vinel

11

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20 February 2020

Marie-Adeline Marques

12

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20 February 2020

Oksana Kunduzova

14

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20 February 2020

Jean-Pierre Salles

15

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20 February 2020

Maithé Tauber

16

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20 February 2020

language of work or name

English

0 references

publication date

6 October 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25288766%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

20 February 2020

published in

1 reference

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20 February 2020

volume

111

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20 February 2020

issue

42

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20 February 2020

page(s)

E4494-503

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Induction of a tumor-associated activating mutation in protein tyrosine phosphatase Ptpn11 (Shp2) enhances mitochondrial metabolism, leading to oxidative stress and senescence

20 February 2020

cites work

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Activating mutations in protein tyrosine phosphatase Ptpn11 (Shp2) enhance reactive oxygen species production that contributes to myeloproliferative disorder

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Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations

6 July 2018

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Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature.

6 July 2018

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Adipose-specific deletion of Src homology phosphatase 2 does not significantly alter systemic glucose homeostasis

6 July 2018

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Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation.

6 July 2018

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MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1(L613V) mutation

6 July 2018

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6 July 2018

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Altered glucose homeostasis in mice with liver-specific deletion of Src homology phosphatase 2

6 July 2018

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6 July 2018

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Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis

6 July 2018

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The tyrosine phosphatase Shp2 in development and cancer

6 July 2018

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Functional effects of PTPN11 (SHP2) mutations causing LEOPARD syndrome on epidermal growth factor-induced phosphoinositide 3-kinase/AKT/glycogen synthase kinase 3beta signaling

6 July 2018

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PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice

6 July 2018

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6 July 2018

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A conserved mechanism for control of human and mouse embryonic stem cell pluripotency and differentiation by shp2 tyrosine phosphatase

6 July 2018

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Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death

6 July 2018

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Phosphatase-defective LEOPARD syndrome mutations in PTPN11 gene have gain-of-function effects during Drosophila development

6 July 2018

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Localization of PTP-1B, SHP-2, and Src exclusively in rat brain mitochondria and functional consequences.

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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SHP-2 positively regulates myogenesis by coupling to the Rho GTPase signaling pathway

6 July 2018

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Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment

6 July 2018

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Troglitazone ameliorates abnormal activity of protein tyrosine phosphatase in adipose tissues of Otsuka Long-Evans Tokushima Fatty rats

6 July 2018

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6 July 2018

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Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2.

6 July 2018

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Stimulation of lipolysis and hormone-sensitive lipase via the extracellular signal-regulated kinase pathway

6 July 2018

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Insulin signaling in mice expressing reduced levels of Syp.

6 July 2018

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Identification of Shp-2 as a Stat5A phosphatase

6 July 2018

1 reference

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Expression of a dominant negative SHP-2 in transgenic mice induces insulin resistance.

21 January 2018

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Health and quality of life in adults with Noonan syndrome

21 January 2018

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Growth standards of patients with Noonan and Noonan-like syndromes with mutations in the RAS/MAPK pathway.

21 January 2018

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SHP-2 positively regulates adipogenic differentiation in 3T3-L1 cells.

21 January 2018

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The PTPN11 loss-of-function mutation Q510E-Shp2 causes hypertrophic cardiomyopathy by dysregulating mTOR signaling

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25288766

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Body Mass Index variations: centiles from birth to 87 years

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25288766

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Alterations in specific protein-tyrosine phosphatases accompany insulin resistance of streptozotocin diabetes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25288766

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1406107111

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25288766%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25288766%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

PubMed publication ID

25288766

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25288766%20AND%20SRC:MED&resulttype=core&format=json