The tyrosine phosphatase Shp2 in development and cancer (Q37732956)

22 August 2017

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title

The tyrosine phosphatase Shp2 in development and cancer (English)

1 reference

22 August 2017

3

Carmen Birchmeier

1 reference

22 August 2017

Katja S Grossmann

1

1 reference

PubMed ID

20399956

22 August 2017

Marta Rosário

series ordinal

2

1 reference

PubMed ID

20399956

22 August 2017

Walter Birchmeier

series ordinal

4

1 reference

22 August 2017

1 January 2010

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Advances in Cancer Research

22 August 2017

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22 August 2017

106

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22 August 2017

53-89

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Molecular cloning of a novel protein‐tyrosine phosphatase SH‐PTP3 with sequence similarity to the src‐homology region 2

22 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Selective requirement for MAP kinase activation in thymocyte differentiation.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

PTP1D is a positive regulator of the prolactin signal leading to beta-casein promoter activation.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

SHP-2 Regulates SOCS-1-mediated Janus Kinase-2 Ubiquitination/Degradation Downstream of the Prolactin Receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Insulin signaling in mice expressing reduced levels of Syp.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Dominant negative variants of the SHP-2 tyrosine phosphatase inhibit prolactin activation of Jak2 (janus kinase 2) and induction of Stat5 (signal transducer and activator of transcription 5)-dependent transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

ErbB receptors and the development of the nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Met provides essential signals for liver regeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Building the mammalian heart from two sources of myocardial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

The tyrosine phosphatase Shp2 (PTPN11) in cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Identification of Shp-2 as a Stat5A phosphatase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Prevalence of priapism in children and adolescents with sickle cell anemia.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Molecular control of neural crest formation, migration and differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Prolactin induces SHP-2 association with Stat5, nuclear translocation, and binding to the beta-casein gene promoter in mammary cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Noonan Syndrome and Neuroblastoma

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Neural crest stem and progenitor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Genetic insights into trophoblast differentiation and placental morphogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Familial aggregation of genetically heterogeneous hypertrophic cardiomyopathy: a boy with LEOPARD syndrome due to PTPN11 mutation and his nonsyndromic father lacking PTPN11 mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Neu differentiation factor is a neuron-glia signal and regulates survival, proliferation, and maturation of rat Schwann cell precursors.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Juvenile myelomonocytic leukemia: molecular understanding and prospects for therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

The role of hepatocytes and oval cells in liver regeneration and repopulation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Requirement of FGF-4 for postimplantation mouse development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Shp2-mediated molecular signaling in control of embryonic stem cell self-renewal and differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

SHP-2 activates signaling of the nuclear factor of activated T cells to promote skeletal muscle growth

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

A dual role of erbB2 in myelination and in expansion of the schwann cell precursor pool

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Control of CNS cell-fate decisions by SHP-2 and its dysregulation in Noonan syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Paracrine action of FGF4 during periimplantation development maintains trophectoderm and primitive endoderm

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

The docking protein FRS2alpha is an essential component of multiple fibroblast growth factor responses during early mouse development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

The tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

The Caenorhabditis elegans SH2 domain-containing protein tyrosine phosphatase PTP-2 participates in signal transduction during oogenesis and vulval development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Shp2 acts downstream of SDF-1alpha/CXCR4 in guiding granule cell migration during cerebellar development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Reduced phosphatase activity of SHP-2 in LEOPARD syndrome: consequences for PI3K binding on Gab1

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Information networks in the mammary gland.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Crystal structure of the tyrosine phosphatase SHP-2

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Regulation of the growth of multinucleated muscle cells by an NFATC2-dependent pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

A case of Noonan's syndrome with possible associated neuroblastoma

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

SHP-2 regulates the phosphatidylinositide 3'-kinase/Akt pathway and suppresses caspase 3-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

The origin and development of glial cells in peripheral nerves

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Single factors direct the differentiation of stem cells from the fetal and adult central nervous system.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Conditional deletion of Shp2 in the mammary gland leads to impaired lobulo-alveolar outgrowth and attenuated Stat5 activation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Altered primary myogenesis in NFATC3(-/-) mice leads to decreased muscle size in the adult

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

PTPN11 mutations in patients with LEOPARD syndrome: a French multicentric experience

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Role of neural crest in congenital heart disease

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Neural crest cells contribute to normal aorticopulmonary septation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

SHP-2 positively regulates myogenesis by coupling to the Rho GTPase signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

PTPN11 (Shp2) mutations in LEOPARD syndrome have dominant negative, not activating, effects

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase/mitogen-activated protein kinase and RhoA signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Development of diabesity in mice with neuronal deletion of Shp2 tyrosine phosphatase.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

The protein kinases ERK1/2 and their roles in pancreatic beta cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Neural crest cell plasticity and its limits

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Progenitor cells: what do they know and when do they know it?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Stat5a is mandatory for adult mammary gland development and lactogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

PTPN11 mutations in pediatric patients with acute myeloid leukemia: results from the Children's Cancer Group

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Noonan syndrome associated with neuroblastoma: a case report.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

erbb3 and erbb2 are essential for schwann cell migration and myelination in zebrafish.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Congenital heart diseases in children with Noonan syndrome: An expanded cardiac spectrum with high prevalence of atrioventricular canal

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Activating PTPN11 mutations play a minor role in pediatric and adult solid tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

An essential role for a MEK-C/EBP pathway during growth factor-regulated cortical neurogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Multiple essential functions of neuregulin in development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Axonal neuregulin-1 regulates myelin sheath thickness

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Timing is everything: making neurons versus glia in the developing cortex

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Isolation of a distinct class of gain-of-function SHP-2 mutants with oncogenic RAS-like transforming activity from solid tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Profound block in thymocyte development in mice lacking p56lck

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Rescue of the cardiac defect in ErbB2 mutant mice reveals essential roles of ErbB2 in peripheral nervous system development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Spectrum of mutations in PTPN11 and genotype-phenotype correlation in 96 patients with Noonan syndrome and five patients with cardio-facio-cutaneous syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Protein tyrosine phosphatase activity in the neural crest is essential for normal heart and skull development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Noonan syndrome is associated with enhanced pERK activity, the repression of which can prevent craniofacial malformations

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Conditional deletion of Shp2 tyrosine phosphatase in thymocytes suppresses both pre-TCR and TCR signals.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Functional analysis of PTPN11/SHP-2 mutants identified in Noonan syndrome and childhood leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Hypertelorism With Turner Phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Noonan syndrome and related disorders: alterations in growth and puberty

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Transgenic Drosophila models of Noonan syndrome causing PTPN11 gain-of-function mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Phosphatase-defective LEOPARD syndrome mutations in PTPN11 gene have gain-of-function effects during Drosophila development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

1 reference

7 January 2021

Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

The phosphatase SHP2 regulates the spacing effect for long-term memory induction

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Role of the SHP-2 tyrosine phosphatase in cytokine-induced signaling and cellular response

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Basic fibroblast growth factor (Fgf2) is necessary for cell proliferation and neurogenesis in the developing cerebral cortex.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Severe neuropathies in mice with targeted mutations in the ErbB3 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Germline gain-of-function mutations in SOS1 cause Noonan syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

How to make tubes: signaling by the Met receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

The neurite outgrowth multiadaptor RhoGAP, NOMA-GAP, regulates neurite extension through SHP2 and Cdc42

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https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Stem cells from the Mammalian blastocyst

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7 January 2021

Placental development: lessons from mouse mutants

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7 January 2021

An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development

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7 January 2021

Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2.

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7 January 2021

Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

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https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

The protein tyrosine phosphatase Shp-2 regulates RhoA activity

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7 January 2021

Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells

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7 January 2021

Germline KRAS mutations cause Noonan syndrome

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7 January 2021

The Shp-2 tyrosine phosphatase has opposite effects in mediating the activation of extracellular signal-regulated and c-Jun NH2-terminal mitogen-activated protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Making or breaking the heart: from lineage determination to morphogenesis

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https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms

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7 January 2021

Activated Ras signals differentiation and expansion of CD4+8+ thymocytes

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7 January 2021

Promotion of trophoblast stem cell proliferation by FGF4

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https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development

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https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Noonan syndrome and related disorders: genetics and pathogenesis

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https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

1 reference

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7 January 2021

PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity

1 reference

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7 January 2021

Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

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7 January 2021

Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia

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https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Somatic PTPN11 mutations in childhood acute myeloid leukaemia

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7 January 2021

Diversity and functional consequences of germline and somatic PTPN11 mutations in human disease

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https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Neuregulin-1 type III determines the ensheathment fate of axons

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7 January 2021

Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes

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7 January 2021

Gain-of-function/Noonan syndrome SHP-2/Ptpn11 mutants enhance calcium oscillations and impair NFAT signaling

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https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation

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7 January 2021

Mammary development in the embryo and adult: a journey of morphogenesis and commitment

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7 January 2021

A PDGF-regulated immediate early gene response initiates neuronal differentiation in ventricular zone progenitor cells.

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7 January 2021

Peripheral nervous system defects in erbB2 mutants following genetic rescue of heart development.

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7 January 2021

SHP-2 is a dual-specificity phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues in nuclei

1 reference

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7 January 2021

A conserved mechanism for control of human and mouse embryonic stem cell pluripotency and differentiation by shp2 tyrosine phosphatase

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7 January 2021

Interleukin-6/glycoprotein 130-dependent pathways are protective during liver regeneration

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7 January 2021

Essential role of Shp2-binding sites on FRS2alpha for corticogenesis and for FGF2-dependent proliferation of neural progenitor cells

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7 January 2021

PTPN11, RAS and FLT3 mutations in childhood acute lymphoblastic leukemia

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https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival

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7 January 2021

Activating PTPN11 mutants promote hematopoietic progenitor cell-cycle progression and survival

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7 January 2021

Protein-tyrosine phosphatase, nonreceptor type 11 mutation analysis and clinical assessment in 45 patients with Noonan syndrome.

1 reference

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7 January 2021

Modulation of the nuclear factor kappa B pathway by Shp-2 tyrosine phosphatase in mediating the induction of interleukin (IL)-6 by IL-1 or tumor necrosis factor

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7 January 2021

Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion

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7 January 2021

Effects of a leukemia-associated gain-of-function mutation of SHP-2 phosphatase on interleukin-3 signaling

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7 January 2021

Genotype-phenotype correlations in Noonan syndrome

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7 January 2021

Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2.

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7 January 2021

Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism

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7 January 2021

Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cells

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https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia

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https://api.crossref.org/works/10.1016%2FS0065-230X%2810%2906002-1

7 January 2021

Liver regeneration. 2. Role of growth factors and cytokines in hepatic regeneration

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7 January 2021

10.1016/S0065-230X(10)06002-1

Identifiers

DOI

1 reference

22 August 2017

1 reference

PubMed ID

20399956