A phenotypic assay to identify Chikungunya virus inhibitors targeting the nonstructural protein nsP2. (Q34415623)

2 August 2017

A phenotypic assay to identify Chikungunya virus inhibitors targeting the nonstructural protein nsP2. (English)

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2 August 2017

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Pierre-Olivier Vidalain

9

Pierre-Olivier Vidalain

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Hélène Munier-Lehmann

Hélène Munier-Lehmann

10

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Alexandru Lupan

Alexandru Lupan

2

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Philippe Desprès

3

Philippe Desprès

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2 August 2017

8

Frédéric Tangy

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2 August 2017

Marianne Lucas-Hourani

1

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2 August 2017

Sylviane Thoret

4

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2 August 2017

Olivier Pamlard

5

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2 August 2017

Joëlle Dubois

6

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2 August 2017

Catherine Guillou

7

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2 August 2017

language of work or name

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14 September 2012

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Journal of Biomolecular Screening

2 August 2017

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2 August 2017

18

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2 August 2017

172-179

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2 August 2017

2

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Firefly luciferase gene: structure and expression in mammalian cells

2 August 2017

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Bioluminescent assays for high-throughput screening

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Herpes simplex virus type 1 origins of DNA replication play no role in the regulation of flanking promoters

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Proteomic analysis of virus-host interactions in an infectious context using recombinant viruses

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Polymerase activity of in vitro mutated rabies virus L protein

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Inhibitors of alphavirus entry and replication identified with a stable Chikungunya replicon cell line and virus-based assays

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Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein

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Chikungunya: a re-emerging virus

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Inhibition of Chikungunya virus infection in cultured human muscle cells by furin inhibitors: impairment of the maturation of the E2 surface glycoprotein

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On chikungunya acute infection and chloroquine treatment

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Cellular IMPDH enzyme activity is a potential target for the inhibition of Chikungunya virus replication and virus induced apoptosis in cultured mammalian cells

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A structural and functional perspective of alphavirus replication and assembly

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Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling

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Chikungunya virus induces IPS-1-dependent innate immune activation and protein kinase R-independent translational shutoff

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Mapping of Chikungunya virus interactions with host proteins identified nsP2 as a highly connected viral component

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1 reference

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Evasion of the innate immune response: the Old World alphavirus nsP2 protein induces rapid degradation of Rpb1, a catalytic subunit of RNA polymerase II

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Construction of an infectious Chikungunya virus cDNA clone and stable insertion of mCherry reporter genes at two different sites

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

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Roles of nonstructural protein nsP2 and Alpha/Beta interferons in determining the outcome of Sindbis virus infection

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Semliki Forest virus nonstructural protein 2 is involved in suppression of the type I interferon response

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Recent advances in targeting viral proteases for the discovery of novel antivirals

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Inhibitors of the interactions between HIV-1 IN and the cofactor LEDGF/p75.

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Identifiers

DOI

10.1177/1087057112460091

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2 August 2017

1 reference