Inhibitors of the interactions between HIV-1 IN and the cofactor LEDGF/p75. (Q37867081)

24 August 2017

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title

Inhibitors of the interactions between HIV-1 IN and the cofactor LEDGF/p75. (English)

1 reference

24 August 2017

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5

Alba Chimirri

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author name string

Laura De Luca

1

1 reference

24 August 2017

Stefania Ferro

2

1 reference

24 August 2017

Francesca Morreale

3

1 reference

24 August 2017

Sara De Grazia

4

1 reference

24 August 2017

19 April 2011

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24 August 2017

1 reference

24 August 2017

6

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24 August 2017

7

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24 August 2017

1184-1191

1 reference

Rationalizing the chemical space of protein-protein interaction inhibitors

24 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Cyclic peptide inhibitors of HIV-1 integrase derived from the LEDGF/p75 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Are protein-protein interfaces more conserved in sequence than the rest of the protein surface?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

A role for LEDGF/p75 in targeting HIV DNA integration

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

An essential role for LEDGF/p75 in HIV integration

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Virological and cellular roles of the transcriptional coactivator LEDGF/p75

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Blocking interactions between HIV-1 integrase and cellular cofactors: an emerging anti-retroviral strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Targeting HIV-1 DNA integration by swapping tethers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

High-level expression of active HIV-1 integrase from a synthetic gene in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

AT-hook motifs identified in a wide variety of DNA-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Molecular biology of HMGA proteins: hubs of nuclear function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Identification and characterization of the chromatin-binding domains of the HIV-1 integrase interactor LEDGF/p75.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Identification of the LEDGF/p75 binding site in HIV-1 integrase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Wild-type levels of human immunodeficiency virus type 1 infectivity in the absence of cellular emerin protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

beta-Peptides as inhibitors of protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

21 January 2018

Peptidomimetic design

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Peptidomimetics - antagonists of the fibrinogen receptors: molecular design, structures, properties and therapeutic applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Molecular modeling in the design of peptidomimetics and peptide surrogates

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Recent advances in design, synthesis and biological activity of aminoalkylsulfonates and sulfonamidopeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Inhibitory profile of a LEDGF/p75 peptide against HIV-1 integrase: insight into integrase-DNA complex formation and catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Mechanism of action of the HIV-1 integrase inhibitory peptide LEDGF 361-370.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Miniaturized proteins: the backbone cyclic proteinomimetic approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Comparison of the conformation of active and nonactive backbone cyclic analogs of substance P as a tool to elucidate features of the bioactive conformation: NMR and molecular dynamics in DMSO and water

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

N-methylation of peptides: a new perspective in medicinal chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

D77, one benzoic acid derivative, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Small molecules targeting the interaction between HIV-1 integrase and LEDGF/p75 cofactor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Development and validation of a genetic algorithm for flexible docking

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Zinc coupling potentiates anti-HIV-1 activity of baicalin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

LigandScout: 3-D pharmacophores derived from protein-bound ligands and their use as virtual screening filters

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

New 4-[(1-benzyl-1H-indol-3-yl)carbonyl]-3-hydroxyfuran-2(5H)-ones, beta-diketo acid analogs as HIV-1 integrase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Discovery of a small-molecule HIV-1 integrase inhibitor-binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

Improving Oral Bioavailability of Peptides by Multiple N-Methylation: Somatostatin Analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

inferred from DOI database lookup

7 January 2021

based on heuristic

Backbone cyclization: A new method for conferring conformational constraint on peptides

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100071

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1002/CMDC.201100071

1 reference

24 August 2017

1 reference