Deep sequencing of systematic combinatorial libraries reveals β-lactamase sequence constraints at high resolution (Q34423146)

2 August 2017

Deep sequencing of systematic combinatorial libraries reveals β-lactamase sequence constraints at high resolution (English)

1 reference

2 August 2017

7

Donna Muzny

0 references

Richard A Gibbs

8

object named as

Richard A Gibbs

1 reference

2 August 2017

Zhifeng Deng

1

1 reference

2 August 2017

Wanzhi Huang

2

1 reference

2 August 2017

Erol Bakkalbasi

3

1 reference

2 August 2017

Nicholas G Brown

4

1 reference

2 August 2017

Carolyn J Adamski

5

1 reference

2 August 2017

Kacie Rice

6

1 reference

2 August 2017

Timothy Palzkill

9

1 reference

2 August 2017

language of work or name

English

0 references

publication date

25 September 2012

1 reference

Journal of Molecular Biology

2 August 2017

1 reference

2 August 2017

424

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2 August 2017

150-167

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2 August 2017

3-4

1 reference

Experimental illumination of a fitness landscape

2 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

Multiple global suppressors of protein stability defects facilitate the evolution of extended-spectrum TEM β-lactamases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

High-resolution mapping of protein sequence-function relationships

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

Optimizing protein stability in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

Stability effects of mutations and protein evolvability

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

Analysis of the plasticity of location of the Arg244 positive charge within the active site of the TEM-1 beta-lactamase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

Rational stabilization of enzymes by computational redesign of surface charge-charge interactions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

Genetic and Structural Characterization of an L201P Global Suppressor Substitution in TEM-1 β-Lactamase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

Increased folding stability of TEM-1 beta-lactamase by in vitro selection

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

Intense neutral drifts yield robust and evolvable consensus proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

Next-generation sequencing: the race is on.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

The continuing challenge of ESBLs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

The stability effects of protein mutations appear to be universally distributed

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

Robustness-epistasis link shapes the fitness landscape of a randomly drifting protein.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

TM4 microarray software suite

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

Comprehensive and quantitative mapping of energy landscapes for protein-protein interactions by rapid combinatorial scanning

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

Mutagenesis-based definitions and probes of residue burial in proteins.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

Genome sequencing in microfabricated high-density picolitre reactors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

A perspective on enzyme catalysis.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

TM4: a free, open-source system for microarray data management and analysis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

Predicting the emergence of antibiotic resistance by directed evolution and structural analysis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

A secondary drug resistance mutation of TEM-1 beta-lactamase that suppresses misfolding and aggregation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

Rapid mapping of protein functional epitopes by combinatorial alanine scanning

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

A natural polymorphism in beta-lactamase is a global suppressor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

Genetic studies of the Lac repressor. XV: 4000 single amino acid substitutions and analysis of the resulting phenotypes on the basis of the protein structure

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

Amino acid sequence determinants of beta-lactamase structure and activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

6 July 2018

Protein stability curves

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

Rapid and efficient site-specific mutagenesis without phenotypic selection

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

Systematic mutation of bacteriophage T4 lysozyme.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

Information-theoretical entropy as a measure of sequence variability

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

Probing beta-lactamase structure and function using random replacement mutagenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

Atomic resolution structures of CTX-M beta-lactamases: extended spectrum activities from increased mobility and decreased stability.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524589

The structural stability of a protein is an important determinant of its proteolytic susceptibility in Escherichia coli

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23017428

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Elucidation of the role of arginine-244 in the turnover processes of class A beta-lactamases

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23017428

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.JMB.2012.09.014

1 reference

2 August 2017

1 reference

2 August 2017

1 reference