Metagenomic small molecule discovery methods (Q34428178)

25000402

2 August 2017

title

Metagenomic small molecule discovery methods (English)

1 reference

2 August 2017

1 reference

Aleksandr Milshteyn

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25000402%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

publication date

1 June 2014

1 reference

25000402

Current Opinion in Microbiology

2 August 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25000402%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

volume

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25000402%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

page(s)

70-75

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25000402%20AND%20SRC:MED&resulttype=core&format=json

An environmental bacterial taxon with a large and distinct metabolic repertoire

11 June 2020

cites work

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6 July 2018

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Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules

6 July 2018

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Discovery and synthetic refactoring of tryptophan dimer gene clusters from the environment

6 July 2018

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Bioprospecting potential of the soil metagenome: novel enzymes and bioactivities

6 July 2018

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Arimetamycin A: improving clinically relevant families of natural products through sequence-guided screening of soil metagenomes

6 July 2018

1 reference

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Reducing assembly complexity of microbial genomes with single-molecule sequencing

6 July 2018

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Metagenomic natural product discovery in lichen provides evidence for a family of biosynthetic pathways in diverse symbioses.

6 July 2018

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Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products

6 July 2018

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Alternative sigma factor over-expression enables heterologous expression of a type II polyketide biosynthetic pathway in Escherichia coli.

6 July 2018

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Deep sequencing of non-ribosomal peptide synthetases and polyketide synthases from the microbiomes of Australian marine sponges.

6 July 2018

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Nearly finished genomes produced using gel microdroplet culturing reveal substantial intraspecies genomic diversity within the human microbiome

6 July 2018

1 reference

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Discovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection.

6 July 2018

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Natural products: a continuing source of novel drug leads

6 July 2018

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Targeted search for actinomycetes from nearshore and deep-sea marine sediments

6 July 2018

1 reference

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Discovery of indolotryptoline antiproliferative agents by homology-guided metagenomic screening.

6 July 2018

1 reference

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The fast changing landscape of sequencing technologies and their impact on microbial genome assemblies and annotation

6 July 2018

1 reference

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Genome streamlining and chemical defense in a coral reef symbiosis.

6 July 2018

1 reference

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New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters

6 July 2018

1 reference

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Selective enrichment of environmental DNA libraries for genes encoding nonribosomal peptides and polyketides by phosphopantetheine transferase-dependent complementation of siderophore biosynthesis.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135586

Genomic sequencing of uncultured microorganisms from single cells

6 July 2018

1 reference

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The natural product domain seeker NaPDoS: a phylogeny based bioinformatic tool to classify secondary metabolite gene diversity

6 July 2018

1 reference

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Natural product biosynthetic gene diversity in geographically distinct soil microbiomes.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135586

A functional screen for recovery of 4'-phosphopantetheinyl transferase and associated natural product biosynthesis genes from metagenome libraries.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135586

Origin and variation of tunicate secondary metabolites

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135586

Environmental DNA-encoded antibiotics fasamycins A and B inhibit FabF in type II fatty acid biosynthesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135586

Cloning and heterologous expression of the vibrioferrin biosynthetic gene cluster from a marine metagenomic library

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135586

Nonlinear electrophoresis for purification of soil DNA for metagenomics

6 July 2018

1 reference

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Heterologous production of bisucaberin using a biosynthetic gene cluster cloned from a deep sea metagenome

6 July 2018

1 reference

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A mass spectrometry-guided genome mining approach for natural product peptidogenomics

6 July 2018

1 reference

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A close relationship between primary nucleotides sequence structure and the composition of functional genes in the genome of prokaryotes.

6 July 2018

1 reference

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The regulation of the secondary metabolism of Streptomyces: new links and experimental advances

6 July 2018

1 reference

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Cloning and characterization of an environmental DNA-derived gene cluster that encodes the biosynthesis of the antitumor substance BE-54017.

6 July 2018

1 reference

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Accessing the hidden majority of marine natural products through metagenomics

6 July 2018

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Single cell genome amplification accelerates identification of the apratoxin biosynthetic pathway from a complex microbial assemblage

6 July 2018

1 reference

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Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

6 July 2018

1 reference

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Gram negative shuttle BAC vector for heterologous expression of metagenomic libraries

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135586

Screening of a soil metatranscriptomic library by functional complementation of Saccharomyces cerevisiae mutants

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135586

Shared Biosynthesis of the Saliniketals and Rifamycins in Salinispora arenicola is Controlled by the sare1259-Encoded Cytochrome P450

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135586

Exploiting the natural diversity of microviridin gene clusters for discovery of novel tricyclic depsipeptides

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135586

Sequence-based analysis of secondary-metabolite biosynthesis in marine actinobacteria

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135586

Identifying natural product biosynthetic genes from a soil metagenome by using T7 phage selection.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135586

Nonlinear electrophoretic response yields a unique parameter for separation of biomolecules.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135586

Automated genome mining for natural products.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135586

Natural products from environmental DNA hosted in Ralstonia metallidurans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135586

Metagenome-derived clones encoding two novel lactonase family proteins involved in biofilm inhibition in Pseudomonas aeruginosa

6 July 2018

1 reference

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A global assembly line for cyanobactins

6 July 2018

1 reference

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The evolution of gene collectives: How natural selection drives chemical innovation.

6 July 2018

1 reference

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Polyketide synthases and nonribosomal peptide synthetases: the emerging view from bacterial genomics

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135586

Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135586

Construction of soil environmental DNA cosmid libraries and screening for clones that produce biologically active small molecules

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135586

Genome-wide high-throughput mining of natural-product biosynthetic gene clusters by phage display

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135586

Subtractive hybridization magnetic bead capture: a new technique for the recovery of full-length ORFs from the metagenome

6 July 2018

1 reference

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Fluorescence in situ hybridization-flow cytometry-cell sorting-based method for separation and enrichment of type I and type II methanotroph populations

6 July 2018

1 reference

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Characterization of a forest soil metagenome clone that confers indirubin and indigo production on Escherichia coli

6 July 2018

1 reference

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Intracellular screen to identify metagenomic clones that induce or inhibit a quorum-sensing biosensor

6 July 2018

1 reference

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Substrate-induced gene-expression screening of environmental metagenome libraries for isolation of catabolic genes

6 July 2018

1 reference

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The Uncultured Microbial Majority

6 July 2018

1 reference

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Integration site for Streptomyces phage phiBT1 and development of site-specific integrating vectors

6 July 2018

1 reference

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Unbiased whole-genome amplification directly from clinical samples

6 July 2018

1 reference

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Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)

6 July 2018

1 reference

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Expression and isolation of antimicrobial small molecules from soil DNA libraries

6 July 2018

1 reference

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Novel natural products from soil DNA libraries in a streptomycete host

6 July 2018

1 reference

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High diversity in DNA of soil bacteria

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135586

Analysis of the integration function of the streptomycete bacteriophage φC31

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4135586

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

6 July 2018

1 reference

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A plasmid RK2-based broad-host-range cloning vector useful for transfer of metagenomic libraries to a variety of bacterial species

27 October 2018

1 reference

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A new approach to retrieve full lengths of functional genes from soil by PCR-DGGE and metagenome walking

27 October 2018

1 reference

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Pederin-type pathways of uncultivated bacterial symbionts: analysis of o-methyltransferases and generation of a biosynthetic hybrid.

27 October 2018

1 reference

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Novel techniques for analysing microbial diversity in natural and perturbed environments

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25000402

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.MIB.2014.05.021

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25000402%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25000402%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

25000402

1 reference