Phospholipase D stabilizes HDM2 through an mTORC2/SGK1 pathway (Q34440440)

2 August 2017

title

Phospholipase D stabilizes HDM2 through an mTORC2/SGK1 pathway (English)

1 reference

2 August 2017

Donggon Lyo

1

1 reference

2 August 2017

Limei Xu

series ordinal

2

1 reference

2 August 2017

David A Foster

series ordinal

3

1 reference

2 August 2017

language of work or name

English

0 references

publication date

8 May 2010

1 reference

Biochemical and Biophysical Research Communications

2 August 2017

published in

1 reference

2 August 2017

volume

396

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2 August 2017

issue

2

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2 August 2017

page(s)

562-565

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mTOR complex-2 activates ENaC by phosphorylating SGK1.

2 August 2017

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6 July 2018

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Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation.

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin

6 July 2018

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6 July 2018

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mTOR signaling: PLD takes center stage

6 July 2018

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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

6 July 2018

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mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation

6 July 2018

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

6 July 2018

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

6 July 2018

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HIF alpha expression in VHL-deficient renal cancer cells is dependent on phospholipase D.

6 July 2018

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Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR

6 July 2018

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Defining the role of mTOR in cancer

6 July 2018

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AKT/PKB signaling: navigating downstream

6 July 2018

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IL-2 signals through Sgk1 and inhibits proliferation and apoptosis in kidney cancer cells

6 July 2018

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(Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms

6 July 2018

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TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

6 July 2018

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mTOR and cancer: insights into a complex relationship

6 July 2018

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

6 July 2018

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Sgk kinases and their role in epithelial transport

6 July 2018

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Glycogen synthase kinase 3-dependent phosphorylation of Mdm2 regulates p53 abundance

6 July 2018

1 reference

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

6 July 2018

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

6 July 2018

1 reference

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Phospholipase D elevates the level of MDM2 and suppresses DNA damage-induced increases in p53.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010228

PKB binding proteins. Getting in on the Akt.

6 July 2018

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

6 July 2018

1 reference

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Phosphorylation of HDM2 by Akt.

6 July 2018

1 reference

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Phosphatidic acid-mediated mitogenic activation of mTOR signaling

6 July 2018

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HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

6 July 2018

1 reference

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A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

6 July 2018

1 reference

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MDM2--master regulator of the p53 tumor suppressor protein

6 July 2018

1 reference

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Regulation of p53 stability

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010228

Functions of the MDM2 oncoprotein

6 July 2018

1 reference

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Relative resistance of SGK1 knockout mice against chemical carcinogenesis.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010228

mTORC2 is the hydrophobic motif kinase for SGK1.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010228

mTOR and Akt signaling in cancer: SGK cycles in.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010228

10.1016/J.BBRC.2010.04.148

27 October 2018

Identifiers

DOI

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release_he4rpkavyngv5bfuroguocfzcm

2 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/he4rpkavyngv5bfuroguocfzcm

mapped directly with Wikidata item

24 November 2022

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PMC publication ID

3010228

1 reference

2 August 2017

1 reference