MDM2--master regulator of the p53 tumor suppressor protein (Q28138926)

Recruitment of p300/CBP in p53-dependent signal pathways

Europe PubMed Central

title

MDM2--master regulator of the p53 tumor suppressor protein (English)

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author name string

J Momand

series ordinal

1

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H H Wu

series ordinal

2

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G Dasgupta

series ordinal

3

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language of work or name

English

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publication date

25 January 2000

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published in

Gene

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volume

242

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page(s)

15-29

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issue

1-2

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cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Enhanced phosphorylation of p53 by ATM in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

mdm2 expression is induced by wild type p53 activity

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

The proliferation of normal human fibroblasts is dependent upon negative regulation of p53 function by mdm2.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Tolerance of high levels of wild-type p53 in transformed epithelial cells dependent on auto-regulation by mdm-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

The p53-associated protein MDM2 contains a newly characterized zinc-binding domain called the RING finger

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Solution conformation of an essential region of the p53 transactivation domain

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Mapping of the p53 and mdm-2 interaction domains

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Proteolytic cleavage of the mdm2 oncoprotein during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

The INK4a/ARF tumor suppressor: one gene--two products--two pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Thymocyte apoptosis induced by p53-dependent and independent pathways.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

High-resolution structure of the oligomerization domain of p53 by multidimensional NMR

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

E1A signaling to p53 involves the p19(ARF) tumor suppressor

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Inactivation of the p53-homologue p73 by the mdm2-oncoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Definition of a consensus binding site for p53

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

WAF1, a potential mediator of p53 tumor suppression

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

The MDM2 oncoprotein binds specifically to RNA through its RING finger domain

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Identification of the MDM2 oncoprotein as a substrate for CPP32-like apoptotic proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Presence of a potent transcription activating sequence in the p53 protein

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Expression of wild-type p53 is required for efficient global genomic nucleotide excision repair in UV-irradiated human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Functions of the MDM2 oncoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

The p53 protein is an unusually shaped tetramer that binds directly to DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Translational regulation of human p53 gene expression.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

The complexity of p53 modulation: emerging patterns from divergent signals

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Transgenic mouse model for studying the transcriptional activity of the p53 protein: age- and tissue-dependent changes in radiation-induced activation during embryogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

p300/MDM2 complexes participate in MDM2-mediated p53 degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Synergistic activation of transcription by CBP and p53

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

The mdm2 proto-oncogene

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Mdm2 promotes the rapid degradation of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

1 reference

7 January 2021

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

RB regulates the stability and the apoptotic function of p53 via MDM2

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Regulation of the specific DNA binding function of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

The cellular oncogene p53 can be activated by mutagenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

p73 is a simian [correction of human] p53-related protein that can induce apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Regulation of p53 stability by Mdm2

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Regulation of Mdm2-directed degradation by the C terminus of p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

p19ARF prevents G1 cyclin-dependent kinase activation by interacting with MDM2 and activating p53 in mouse fibroblasts.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Metal and RNA binding properties of the hdm2 RING finger domain

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to U1A-positive nuclear bodies associated with the PODs

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

MDM2--arbiter of p53's destruction

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Solution structure of the tetrameric minimum transforming domain of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

p53, the cellular gatekeeper for growth and division

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Binding and modulation of p53 by p300/CBP coactivators

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

p53 is required for radiation-induced apoptosis in mouse thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

A new class of yeast transcriptional activators

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Oligomerization is required for p53 to be efficiently ubiquitinated by MDM2

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Conservation of structural domains and biochemical activities of the MDM2 protein from Xenopus laevis.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Mdm-2: "big brother" of p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

The MDM2 gene amplification database

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

p53 Protein exhibits 3'-to-5' exonuclease activity

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Amplification of a gene encoding a p53-associated protein in human sarcomas

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Cloning and functional analysis of human p51, which structurally and functionally resembles p53

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Mdm2: keeping p53 under control

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Signaling to p53: breaking the MDM2-p53 circuit

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Identification of a growth suppression domain within the retinoblastoma gene product

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Deletion of 5'-coding sequences of the cellular p53 gene in mouse erythroleukemia: a novel mechanism of oncogene regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

DNA damage induces phosphorylation of the amino terminus of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Structural aspects of the p53 protein in relation to gene evolution: a second look.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

MDM2 interacts with MDMX through their RING finger domains

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Murine double minute (MDM2) blocks p53-coactivator interaction, a new mechanism for inhibition of p53-dependent gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Interaction of p53 with its consensus DNA-binding site

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Nucleolar Arf sequesters Mdm2 and activates p53

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

p53 and E2F-1 cooperate to mediate apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

The p53-mdm-2 autoregulatory feedback loop

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Interaction between the retinoblastoma protein and the oncoprotein MDM2

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

MDM2 suppresses p73 function without promoting p73 degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021