Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity (Q34449244)

2 August 2017

Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity (English)

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2 August 2017

endoplasmic reticulum

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6

Gökhan S Hotamisligil

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2 August 2017

4

Ekin Güney

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2 August 2017

1

Ana Paula Arruda

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2 August 2017

Benedicte M Pers

2

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2 August 2017

Güneş Parlakgül

series ordinal

3

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2 August 2017

Karen Inouye

series ordinal

5

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2 August 2017

language of work or name

English

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publication date

24 November 2014

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2 August 2017

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2 August 2017

20

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2 August 2017

12

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2 August 2017

1427-1435

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describes a project that uses

2 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4412031/fullTextXML

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/nm.3735

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cites work

Mitochondria-associated endoplasmic reticulum membrane (MAM) integrity is required for insulin signaling and is implicated in hepatic insulin resistance

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Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance.

6 July 2018

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Autophagosomes form at ER-mitochondria contact sites

6 July 2018

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Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease

6 July 2018

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Proteasome dysfunction mediates obesity-induced endoplasmic reticulum stress and insulin resistance in the liver

6 July 2018

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Endoplasmic reticulum-mitochondria contacts: function of the junction

6 July 2018

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Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

6 July 2018

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Mitochondria as sensors and regulators of calcium signalling

6 July 2018

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Mitochondrial Ca(2+) and neurodegeneration

6 July 2018

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Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity

6 July 2018

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Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes

6 July 2018

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An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers

6 July 2018

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Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

6 July 2018

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Role of endoplasmic reticulum stress in metabolic disease and other disorders.

6 July 2018

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The unfolded protein response: from stress pathway to homeostatic regulation

6 July 2018

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Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle

6 July 2018

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ER tubules mark sites of mitochondrial division

6 July 2018

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Urban planning of the endoplasmic reticulum (ER): how diverse mechanisms segregate the many functions of the ER.

6 July 2018

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A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

6 July 2018

1 reference

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Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

6 July 2018

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Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress

6 July 2018

1 reference

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Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

6 July 2018

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Sodium phenylbutyrate, a drug with known capacity to reduce endoplasmic reticulum stress, partially alleviates lipid-induced insulin resistance and beta-cell dysfunction in humans

6 July 2018

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Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.

6 July 2018

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Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women.

6 July 2018

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Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

6 July 2018

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The role of mitochondria in the pathogenesis of type 2 diabetes

6 July 2018

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Prevalence and trends in obesity among US adults, 1999-2008

6 July 2018

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Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response.

6 July 2018

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GM1-ganglioside accumulation at the mitochondria-associated ER membranes links ER stress to Ca(2+)-dependent mitochondrial apoptosis

6 July 2018

1 reference

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Foxo1 integrates insulin signaling with mitochondrial function in the liver

6 July 2018

1 reference

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Ca(2+) transfer from the ER to mitochondria: when, how and why

6 July 2018

1 reference

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Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss

6 July 2018

1 reference

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Mitofusin 2 tethers endoplasmic reticulum to mitochondria

6 July 2018

1 reference

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Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis

6 July 2018

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Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals

6 July 2018

1 reference

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Role of mitochondrial dysfunction in insulin resistance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412031

Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases

6 July 2018

1 reference

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Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412031

Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412031

Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412031

Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412031

Measuring calcium signaling using genetically targetable fluorescent indicators

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412031

Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412031

Inflammation and metabolic disorders

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412031

Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412031

Structural and functional features and significance of the physical linkage between ER and mitochondria.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412031

Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412031

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412031

PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412031

Mitochondrial dysfunction and type 2 diabetes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412031

Mitochondrial dysfunction in the elderly: possible role in insulin resistance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412031

Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412031

Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412031

Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms

6 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM.3735

Imaging interorganelle contacts and local calcium dynamics at the ER-mitochondrial interface

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM.3735

Effects of a high-fat diet on energy metabolism and ROS production in rat liver

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25419710

12 December 2020

inferred from PubMed ID database lookup

Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25419710

12 December 2020

inferred from PubMed ID database lookup

Endoplasmic reticulum calcium release through ITPR2 channels leads to mitochondrial calcium accumulation and senescence

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM.3735

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NM.3735

1 reference

2 August 2017

1 reference

2 August 2017

1 reference